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The 2(nd) Berlin BedRest Study: protocol and implementation. (Articolo in rivista)

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The 2(nd) Berlin BedRest Study: protocol and implementation. (Articolo in rivista) (literal)

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Belavy DL 1, Bock O 1, Börst H 1, Armbrecht G 1, Gast U 1, Degner C 1, Beller G 1, Soll H 2, Salanova M 3, Habazettl H. 4, Heer M 5, de Haan A 6, Stegeman DF 6,7, Cerretelli P 8, Blottner D 3, Rittweger J 9, Gelfi C 10, Kornak U 11, Felsenberg D 1 (2010)
The 2(nd) Berlin BedRest Study: protocol and implementation.
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Belavy DL 1, Bock O 1, Börst H 1, Armbrecht G 1, Gast U 1, Degner C 1, Beller G 1, Soll H 2, Salanova M 3, Habazettl H. 4, Heer M 5, de Haan A 6, Stegeman DF 6,7, Cerretelli P 8, Blottner D 3, Rittweger J 9, Gelfi C 10, Kornak U 11, Felsenberg D 1 (literal)

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1. Charité Universitätsmedizin Berlin, Center of Muscle and Bone Research, Berlin (Germany); 2. German Aerospace Center (DLR), Department of Aviation and Space Psychology, Hamburg (Germany); 3. Charité Universitätsmedizin Berlin, Vegetative Anatomy and Center of Space Medicine Berlin, Berlin (Germany); 4. Charité Universitätsmedizin Berlin, Institute for Physiology, Berlin (Germany); 5. German Aerospace Center (DLR), Institute of Aerospace Medicine and Space Physiology Linderhöhe, Köln (Germany); 6. Faculty of Human Movement Sciences, Research Institute MOVE, VU University, Amsterdam (The Netherlands); 7. Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Department of Clinical Neurophysiology, Nijmegen (The Netherlands); 8. Institute of Molecular Bioimaging and Physiology (IBFM), Segrate (M); 9. Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, Manchester (England); 10. University of Milano, Dept. Sciences and Biomedical Technologies, Segrate (MI); 11. Charité Universitätsmedizin Berlin, Center of Gynecology, Perinatal, Pediatric and Adolescent Medicine, Berlin (Germany) (literal)

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Long-term bed-rest is used to simulate the effect of spaceflight on the human body and test different kinds of countermeasures. The 2nd Berlin BedRest Study (BBR2-2) tested the efficacy of whole-body vibration in addition to high-load resisitance exercise in preventing bone loss during bed-rest. Here we present the protocol of the study and discuss its implementation. Twenty-four male subjects underwent 60-days of six-degree head down tilt bed-rest and were randomised to an inactive control group (CTR), a high-load resistive exercise group (RE) or a high-load resistive exercise with whole-body vibration group (RVE). Subsequent to events in the course of the study (e.g. subject withdrawal), 9 subjects participated in the CTR-group, 7 in the RVE-group and 8 (7 beyond bed-rest day-30) in the RE-group. Fluid intake, urine output and axiallary temperature increased during bed-rest (p<.0001), though similarly in all groups (p>=.17). Body weight changes differed between groups (p<.0001) with decreases in the CTR-group, marginal decreases in the RE-group and the RVE-group displaying significant decreases in body-weight beyond bed-rest day-51 only. In light of events and experiences of the current study, recommendations on various aspects of bed-rest methodology are also discussed. (literal)

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