LIPID PROFILING OF HIGH-FAT-FED MICE AFTER DIETARY KRILL OIL SUPPLEMENTATION (Comunicazione a convegno)

Type
Label
  • LIPID PROFILING OF HIGH-FAT-FED MICE AFTER DIETARY KRILL OIL SUPPLEMENTATION (Comunicazione a convegno) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Alternative label
  • Fabiana Piscitelli, Anna Rita Sirigu, Tiziana Bisogno, Claudia Vacca, Kjetil Berge, Sally Tandy, Jeffrey S. Cohn, Sebastiano Banni, Vincenzo Di Marzo (2010)
    LIPID PROFILING OF HIGH-FAT-FED MICE AFTER DIETARY KRILL OIL SUPPLEMENTATION
    in Cannabinoids in Biology and Medicine, Jerusalem, Israel
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Fabiana Piscitelli, Anna Rita Sirigu, Tiziana Bisogno, Claudia Vacca, Kjetil Berge, Sally Tandy, Jeffrey S. Cohn, Sebastiano Banni, Vincenzo Di Marzo (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • Omega-3 polyunsaturated fatty acids (w-3-PUFA) are known to ameliorate several metabolic risk factors for cardiovascular disease. We investigated the dose-dependent effects of dietary w-3-PUFA supplementation, given as Krill oil (KO), on metabolic parameters in high fat diet (HFD)-fed mice. Since an association between elevated endocannabinoid (EC) levels and the metabolic syndrome was reported, we also measured the levels of EC and of their direct biosynthetic precursors, as well as of lipid congeners, in inguinal and epididymal adipose tissue (AT), liver, gastrocnemius muscle, kidneys and heart. Lipids were identified and quantified using high resolution ion trap-time of flight mass spectrometry coupled to liquid chromatography (LC-IT-TOF-MS). Eight-week HFD increased EC levels in all tissues except for epididymal AT, whereas KO reduced anandamide and/or 2-AG levels in all tissues but not in the liver, in a dose-dependent manner. Levels of EC precursors were generally down-regulated, suggesting that KO affects levels of endocannabinoids in part by reducing the availability of their biosynthetic precursors. Our data suggest that KO may promote therapeutic benefit by reducing EC precursor availability and hence EC biosynthesis. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, CNR, Pozzuoli (NA), Italy; 2Dipartimento di Biologia Sperimentale, Università di Cagliari, Italy; and Nutrisearch s.r.l. Pula (CA) Italy; 3Aker BioMarine, Oslo, Norway; 4Nutrition and Metabolism Group, Heart Research Institute, Sydney, Australia. (literal)
Titolo
  • LIPID PROFILING OF HIGH-FAT-FED MICE AFTER DIETARY KRILL OIL SUPPLEMENTATION (literal)
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