http://www.cnr.it/ontology/cnr/individuo/prodotto/ID10472

Cognitive-nigrostriatal relationships in de novo, drug-naïve Parkinson's disease patients: A [I-123]FP-CIT SPECT study. (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Cognitive-nigrostriatal relationships in de novo, drug-naïve Parkinson's disease patients: A [I-123]FP-CIT SPECT study. (Articolo in rivista) (literal)

Anno

2010-01-01T00:00:00+01:00 (literal)

Alternative label

Nobili F. 1, Campus C. 2, Arnaldi D. 1, De Carli F. 3, Cabassi G. 1, Brugnolo A. 1, Dessi B. 1, Morbelli S. 4, Sambuceti G. 4, Abbruzzese G. 5, Rodriguez G. 1 (2010)
Cognitive-nigrostriatal relationships in de novo, drug-naïve Parkinson's disease patients: A [I-123]FP-CIT SPECT study.
in Movement disorders
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Nobili F. 1, Campus C. 2, Arnaldi D. 1, De Carli F. 3, Cabassi G. 1, Brugnolo A. 1, Dessi B. 1, Morbelli S. 4, Sambuceti G. 4, Abbruzzese G. 5, Rodriguez G. 1 (literal)

Pagina inizio

35 (literal)

Pagina fine

43 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

25 (literal)

Rivista

Movement disorders (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

Pubblicato on-line: 10 Gennaio 2010. Corresponding author: Dr. L. Nobili (flaviomariano.nobili@hsanmartino.it) IF 2010: 4.480 (literal)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

1. Department of Neurosciences, Ophthalmology and Genetics, Clinical Neurophysiology Unit, University of Genoa, Genova. 2. Telerobotics and Applications Department (TERA), Italian Institute of Technology, Genova. 3. CNR-Institute of Molecular Bioimaging and Physiology, Genova 4. Department of Internal Medicine, Nuclear Medicine Unit, University of Genoa, Genova 5. Department of Neurosciences, Ophthalmology and Genetics, Centre for Movement Disorders, University of Genoa, Genova. (literal)

Titolo

Cognitive-nigrostriatal relationships in de novo, drug-naïve Parkinson's disease patients: A [I-123]FP-CIT SPECT study. (literal)

Abstract

To unveil cognitive-nigrostriatal correlations in Parkinson's disease (PD), 30 de novo, drug-naïve PD patients and 15 patients with essential tremor (Controls, CTR) underwent a neuropsychological (NPS) battery and brain SPECT with [I-123]Ioflupane, as a biomarker of nigrostriatal function. Automatic extraction of uptake at caudate and putamen level was conducted through the BasGan software, also allowing partial volume effect correction. Because of the multicollinearity among neuropsychological tests and among SPECT variables, factor analysis was applied to 16 neuropsychological scores; moreover, the four SPECT variables were merged into a mean SPECT value (mSPECT). Factor analysis identified four NPS factors: a dys-executive (NPS-EX), a visuospatial (NPS-VS), a verbal memory (NPS-VM), and a \"mixed\" (NPD-MIX) factor. In PD group, there were inverse correlations between UPDRS-III score and both NPS-VS (P < 0.01) and mSPECT (P < 0.05), and a direct correlation between mSPECT and NPS-EX (P < 0.05). Post hoc analysis showed a direct correlation between NPS-EX and caudate uptake in both hemispheres (P < 0.05). Moreover, inverse correlations were found between UPDRS-III and, respectively, putamen uptake in the less affected hemisphere (P < 0.01), and putamen and caudate uptake in the more affected hemisphere (P < 0.05). In CTR, no correlation was found between mSPECT and either NPS or GDS values. Nigro-caudate function affects executive capabilities in PD but not in CTR, which appears to be unrelated to the disease motor severity at its onset. Instead, PD motor severity is related to nigro-putaminal impairment and visuospatial dysfunction. The role of these data as predictive features of cognitive decline and eventually dementia remains to be established in longitudinal studies. (literal)

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