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Subcortical and deep cortical atrophy in frontotemporal lobar degeneration (Articolo in rivista)

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Subcortical and deep cortical atrophy in frontotemporal lobar degeneration (Articolo in rivista) (literal)

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Garibotto V. 1,4, Borroni B. 2, Agosti C. 2, Premi E. 2, Alberici A. 2, Eickhoff S.B. 3,4, Brambati S.M. 5, Bellelli G. 6, Gasparotti R. 7, Perani D. 1, Padovani A. 2 (2011)
Subcortical and deep cortical atrophy in frontotemporal lobar degeneration
in Neurobiology of aging
(literal)

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Garibotto V. 1,4, Borroni B. 2, Agosti C. 2, Premi E. 2, Alberici A. 2, Eickhoff S.B. 3,4, Brambati S.M. 5, Bellelli G. 6, Gasparotti R. 7, Perani D. 1, Padovani A. 2 (literal)

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Pubblicato on-line: 4 Giugno 2009. Corresponding author: B. Borroni (bborroni@inwind.it). IF 2010: 6.634 (literal)

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1. Vita-Salute San Raffaele University, Division of Neuroscience-IRCCS San Raffaele, National Institute of Neuroscience (INN) and IBFM-CNR, Milano. 2. Center for Brain Aging and Neurodegenerative Disorders, University of Brescia, Brescia. 3. Jülich Forschungszentrum, Jülich (Germany) 4. Department of Psychiatry, University Hospital RWTH Aachen, Aachen, (Germany). 5. Department of Medical Sciences, Université de Montreal, Montreal (Canada). 6. Ancelle della Carità Hospital, Cremona 7. Neuroradiology Unit, University of Brescia, Brescia. (literal)

Titolo

Subcortical and deep cortical atrophy in frontotemporal lobar degeneration (literal)

Abstract

Though neuroimaging, pathology and pathophysiology suggest a subcortical and deep cortical involvement in Frontotemporal Lobar Degeneration (FTLD), no studies have comprehensively assessed the associated gray matter (GM) volume changes. We measured caudate, putamen, thalamus, and amygdala GM volume using probabilistic a-priori regions of interest (ROIs) in 53 early FTLD patients (38 behavioral variant FTD [bvFTD], 9 Semantic Dementia [SD], 6 Progressive Non-Fluent Aphasia [PNFA]), and 25 age-matched healthy controls (HC). ANOVA showed significant (P<0.001) main effect of diagnosis, and significant interactions for diagnosis and region, and diagnosis and hemisphere. Post-hoc comparisons with HC showed bilateral GM atrophy in the caudate, putamen and thalamus, in bvFTD; a left-confined GM reduction in the amygdala in SD; and bilateral GM atrophy in the caudate and thalamus, and left-sided GM reduction in the putamen and amygdala in PNFA. Correlation analyses suggested an association between GM volumes and language, psychomotor speed and behavioral disturbances. This study showed a widespread involvement of subcortical and deep cortical GM in early FTLD with patterns specific for clinical entity. (literal)

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