http://www.cnr.it/ontology/cnr/individuo/prodotto/ID10437

Lungs with acute respiratory distress syndrome show diffuse inflammation in normally aerated regions: A [18F]-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography study* (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Lungs with acute respiratory distress syndrome show diffuse inflammation in normally aerated regions: A [18F]-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography study* (Articolo in rivista) (literal)

Anno

2009-01-01T00:00:00+01:00 (literal)

Alternative label

Bellani G. 1,3, Messa C. 2,5, Guerra L. 4, Spagnolli E. 1,2, Foti G. 3, Patroniti N. 3, Fumagalli R. 1,3, Musch G. 6, Fazio F. 2,5, Pesenti A. 1,3 (2009)
Lungs with acute respiratory distress syndrome show diffuse inflammation in normally aerated regions: A [18F]-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography study*
in Critical care medicine
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Bellani G. 1,3, Messa C. 2,5, Guerra L. 4, Spagnolli E. 1,2, Foti G. 3, Patroniti N. 3, Fumagalli R. 1,3, Musch G. 6, Fazio F. 2,5, Pesenti A. 1,3 (literal)

Pagina inizio

2216 (literal)

Pagina fine

2222 (literal)

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37 (literal)

Rivista

Critical care medicine (Rivista)

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Pubblicato on-line: 29 Maggio 2009 Corresponding author: A. Pesenti (antonio.pesenti@unimib.it) I.F. 2009: 6.373 (literal)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

1. Department of Experimental Medicine, University of Milan-Bicocca, Monza. 2. Centro Bioimmagini Molecolari, University of Milan-Bicocca, Monza. 3. Department of Perioperative Medicine and Intensive Care, San Gerardo Hospital, Monza. 4. Nuclear Medicine Unit (LG), San Gerardo Hospital, Monza. 5. CNR-Institute of Molecular Bioimaging and Physiology, Milano. 6. Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA. (USA) (literal)

Titolo

Lungs with acute respiratory distress syndrome show diffuse inflammation in normally aerated regions: A [18F]-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography study* (literal)

Abstract

OBJECTIVE: Neutrophilic inflammation plays a key role in the pathogenesis of acute respiratory distress syndrome (ARDS) and acute lung injury (ALI). Positron emission tomography (PET) with [F]-fluoro-2-deoxy-d-glucose (FDG) can be used to image cellular metabolism that, during lung inflammatory processes, likely reflects neutrophils activity. The aim of this study was to assess the magnitude and regional distribution of inflammatory metabolic activity in the lungs of patients with ALI/ARDS by PET with FDG. DESIGN:: Prospective clinical investigation. PATIENTS:: Ten patients with ALI/ARDS; four spontaneously breathing and two mechanically ventilated subjects, without known lung disease, served as controls. INTERVENTIONS:: In each individual we performed an FDG PET/computed tomography of the thorax. MEASUREMENTS AND MAIN RESULTS:: FDG cellular influx rate constant (Ki) was computed for the imaged lung field and for regions of interest, grouping voxels with similar density. In all patients with ALI/ARDS, Ki was higher than in controls, also after accounting for the increased lung density. Ki values differed greatly among patients, but in all patients Ki of the normally aerated regions was much higher (2- to 24-fold) than in controls. Whereas in some patients the highest Ki values corresponded to regions with the lowest aeration, in others these regions had lower Ki than normally and mildly hypoaerated regions. CONCLUSION:: In patients with ALI/ARDS, undergoing mechanical ventilation since days, the metabolic activity of the lungs is markedly increased across the entire lung density spectrum. The intensity of this activation and its regional distribution, however, vary widely within and between patients. (literal)

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