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Characterization of preclinical models of prostate cancer using PET-based molecular imaging (Articolo in rivista)

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Characterization of preclinical models of prostate cancer using PET-based molecular imaging (Articolo in rivista) (literal)

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Belloli S. 1,2,3, Jachetti E. 4,7, Moresco R.M. 1,2,3, Picchio M. 1,2,3, Lecchi M. 6, Valtorta S. 1,8, Freschi M. 5, Michelini R.H. 4, Bellone M. 4, Fazio F. 1,3 (2009)
Characterization of preclinical models of prostate cancer using PET-based molecular imaging
in European journal of nuclear medicine and molecular imaging (Print)
(literal)

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Belloli S. 1,2,3, Jachetti E. 4,7, Moresco R.M. 1,2,3, Picchio M. 1,2,3, Lecchi M. 6, Valtorta S. 1,8, Freschi M. 5, Michelini R.H. 4, Bellone M. 4, Fazio F. 1,3 (literal)

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Pubblicato on-line: 11 Marzo 2009 Corresponding author: RM Moresco (moresco.rosamaria@hsr.it) I.F. 2009: 4.531 (literal)

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1. Department of Nuclear Medicine, Scientific Institute H San Raffaele, Milano 2. IBFM, CNR, Milano 3. University of Milano-Bicocca, Milano 4. Cancer Immunotherapy and Gene Therapy Program, San Raffaele Scientific Institute, Milano 5. Pathological Anatomy Unit, San Raffaele Scientific Institute, Milano 6. Institute of Radiological Sciences, University of Milan, Milano 7. Fellowship of the Doctorate School of Cellular and Molecular Medicine, University of Vita-Salute, San Raffaele Institute, Milano 8. Fellowship of the Doctorate School of Molecular Medicine, University of Milan, Milano (literal)

Titolo

Characterization of preclinical models of prostate cancer using PET-based molecular imaging (literal)

Abstract

PURPOSE: Transgenic adenocarcinoma of the mouse prostate (TRAMP) mice spontaneously develop hormone-dependent and hormone-independent prostate cancer (PC) that potentially resembles the human pathological condition. The aim of the study was to validate PET imaging as a reliable tool for in vivo assessment of disease biology and progression in TRAMP mice using radioligands routinely applied in clinical practice: [(18)F]FDG and [(11)C]choline. METHODS: Six TRAMP mice were longitudinally evaluated starting at week 11 of age to visualize PC development and progression. The time frame and imaging pattern of PC lesions were subsequently confirmed on an additional group of five mice. RESULTS: PET and [(18)F]FDG allowed detection of PC lesions starting from 23 weeks of age. [(11)C]Choline was clearly taken up only by TRAMP mice carrying neuroendocrine lesions, as revealed by post-mortem histological evaluation. CONCLUSION: PET-based molecular imaging represents a state-of-the-art tool for the in vivo monitoring and metabolic characterization of PC development, progression and differentiation in the TRAMP model. (literal)

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