http://www.cnr.it/ontology/cnr/individuo/prodotto/ID10415

The factorial structure of the mini mental state examination (MMSE) in Alzheimer's disease (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

The factorial structure of the mini mental state examination (MMSE) in Alzheimer's disease (Articolo in rivista) (literal)

Anno

2009-01-01T00:00:00+01:00 (literal)

Alternative label

Brugnolo A 1, Nobili F 1, Barbieri MP 2, Dessi B 1, Ferro A 3, Girtler N 4, Palummeri E 2, Partinico D 5, Raiteri U 6, Regesta G 6, Servetto G 3, Tanganelli P 5, Uva V 7, Mazzei D 1, Donadio S 8, De Carli F 9, Colazzo G 10, Serrati C 10, Rodriguez G. 1 (2009)
The factorial structure of the mini mental state examination (MMSE) in Alzheimer's disease
in Archives of gerontology and geriatrics
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Brugnolo A 1, Nobili F 1, Barbieri MP 2, Dessi B 1, Ferro A 3, Girtler N 4, Palummeri E 2, Partinico D 5, Raiteri U 6, Regesta G 6, Servetto G 3, Tanganelli P 5, Uva V 7, Mazzei D 1, Donadio S 8, De Carli F 9, Colazzo G 10, Serrati C 10, Rodriguez G. 1 (literal)

Pagina inizio

180 (literal)

Pagina fine

185 (literal)

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49 (literal)

Rivista

Archives of gerontology and geriatrics (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

Pubblicato on-line: 16 dicembre 2008 Corresponding author: A. Brugnolo (Andrea.Brugnolo@unige.it) I.F. 2009: 1.360 (literal)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

1. Clinical Neurophysiology Unit, Department of Endocrinological and Medical Science, University of Genova, Genova 2. Inter-company Department, Galliera Hospital, ASL 3, Genova 3. Department of Psychiatry, ASL 2, Savona 4. Clinical Psychology Unit, Department of Law Medicine, University of Genova, Genova 5. Neurology Unit, Padre Antero Hospital, Sestri Ponente (GE) 6. Department of Neurology, S. Martino Hospital, Genova 7. Department of Psychiatry, ASL 4, Chiavari (GE) 8. Department of Physics, University of Genova, Genova 9. Institute of Molecular Bioimaging and Physiology, National Research Council, Genova 10. Neurology Department, ASL 1 General Hospital, Bussana di Sanremo (IM) (literal)

Titolo

The factorial structure of the mini mental state examination (MMSE) in Alzheimer's disease (literal)

Abstract

Our aim was to evaluate the factorial structure of the mini mental state examination (MMSE) in Alzheimer's disease (AD). Five hundred and twenty-four consecutive outpatients at their first diagnostic work-up (age 78.02 ± 6.07 years, education 6.62 ± 3.48 years, mean MMSE score 20.23 ± 4.89) (±S.D.) with probable AD (based on DSM-IV and NINCDS-ADRDA criteria) were enrolled in a multicenter, cross-sectional, regional-based study. For the purpose of the present study, the 11 subtests composing the MMSE and the global MMSE score (ranging from 10 to 29, included) were considered. Factor analysis with Varimax rotation method identified two factors that explained about the 85% of total variance. The first factor explained the 65% of variance and mainly included temporal orientation, delayed recall, attention/concentration, and constructional praxia. The second factor explained the 20% of variance and included reading a sentence, writing a sentence, naming, verbal repetition and immediate memory. The first factor was a reliable index of cognitive deterioration along the MMSE score interval between 29 and 10, whereas the second factor was not a suitable marker in this range. The two-factor structure of the MMSE in AD is shown in a large series of patients. The first factor expresses the ability to use new information and is related with working memory. The second factor is related with a more consolidated knowledge, namely verbal abilities, and is essentially useless in mild to moderate AD. (literal)

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