http://www.cnr.it/ontology/cnr/individuo/prodotto/ID10413

C-11 Choline versus F-18 Fluorodeoxyglucose for imaging meningiomas: an initial experience (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

C-11 Choline versus F-18 Fluorodeoxyglucose for imaging meningiomas: an initial experience (Articolo in rivista) (literal)

Anno

2009-01-01T00:00:00+01:00 (literal)

Alternative label

Giovacchini G. 1, Fallanca F. 2, Landoni C. 1,2, Gianolli L. 2, Picozzi P. 3, Attuati L 3., Terreni M. 4, Picchio M. 2, Messa C. 1,6, Fazio F. 1,2,6 (2009)
C-11 Choline versus F-18 Fluorodeoxyglucose for imaging meningiomas: an initial experience
in Clinical nuclear medicine
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Giovacchini G. 1, Fallanca F. 2, Landoni C. 1,2, Gianolli L. 2, Picozzi P. 3, Attuati L 3., Terreni M. 4, Picchio M. 2, Messa C. 1,6, Fazio F. 1,2,6 (literal)

Pagina inizio

7 (literal)

Pagina fine

10 (literal)

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34 (literal)

Rivista

Clinical nuclear medicine (Rivista)

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Corresponding author: C. Messa (c.messa@hsgerardo.org) IF 2009: 3.915 (literal)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

1. Center for Molecular Bioimaging, University of Milano-Bicocca; 2. Departments of Nuclear Medicine, Scientific Institute San Raffaele, Milano 3. Departments of Neurosurgery, Scientific Institute San Raffaele, Milano 4. Departments of Pathology, Scientific Institute San Raffaele, Milano 5. Department of Nuclear Medicine, San Gerardo Hospital, Monza (MI) 6. Institute for Bioimaging and Molecular Physiology, National Research Council, Milano (literal)

Titolo

C-11 Choline versus F-18 Fluorodeoxyglucose for imaging meningiomas: an initial experience (literal)

Abstract

PURPOSE:: Positron emission tomography/computed tomography (PET/CT) with C-11 choline has been used for staging, restaging, and follow-up of various tumors, whereas its role for imaging meningiomas has only been preliminarily explored. The aim of this study was to compare C-11 choline and F-18 fluorodeoxyglucose (F-18 FDG) uptake in meningiomas and relate these findings to the histopathological analysis. METHODS:: Two sequential three-dimensional PET/CT scans with 370 MBq (10 mCi) of C-11 choline and 370 MBq (10 mCi) of F-18 FDG were performed 2 hours apart in 7 patients with histologically confirmed meningiomas. Five patients had WHO grade I and 2 had WHO grade II meningioma. For each scan, two-dimensional regions of interest were drawn on tumor boundaries and on the contralateral side on CT images and copied to the corresponding PET images. SUVmax and tumor-to-background ratio were calculated. RESULTS:: Relative to the contralateral side, C-11 choline uptake was increased in all meningiomas, whereas F-18 FDG uptake was decreased in 6 patients and increased in 1 of the 2 patients with grade II meningiomas. In the whole group, SUVmax of C-11 choline and F-18 FDG were 3.6 +/- 1.3 and 5.7 +/- 1.3, respectively. The tumor-to-background ratio for C-11 choline was much higher than that for F-18 FDG (5.3 +/- 0.8 vs. 0.9 +/- 0.2, respectively) (P < 0.001). The uptake of C-11 choline was higher in patients with grade II than in grade I meningiomas. CONCLUSIONS:: These preliminary results suggest that C-11 choline may better image meningiomas in comparison with F-18 FDG. Clinical applications of C-11 choline PET/CT for grading and follow-up of meningiomas need to be assessed in further studies. (literal)

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