Proteins modulation in human skeletal muscle in the early phase of adaptation to hypobaric hypoxia. (Articolo in rivista)

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  • Proteins modulation in human skeletal muscle in the early phase of adaptation to hypobaric hypoxia. (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Alternative label
  • Viganò A. 1,2, Ripamonti M. 2, De Palma S. 2,3, Capitanio D. 1,2, Vasso M. 1,2, Wait R. 4, Lundby C. 5,6, Cerretelli P. 2, Gelfi C. 1,2 (2008)
    Proteins modulation in human skeletal muscle in the early phase of adaptation to hypobaric hypoxia.
    in Proteomics (Weinh., Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Viganò A. 1,2, Ripamonti M. 2, De Palma S. 2,3, Capitanio D. 1,2, Vasso M. 1,2, Wait R. 4, Lundby C. 5,6, Cerretelli P. 2, Gelfi C. 1,2 (literal)
Pagina inizio
  • 4668 (literal)
Pagina fine
  • 4679 (literal)
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  • 8 (literal)
Rivista
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  • Pubblicato on-line il 20 Ottobre 2008. Corresponding author: C. Gelfi (cecilia.gelfi@unimi.it) I.F.: 4.586 (literal)
Note
  • ISI Web of Science (WOS) (literal)
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  • 1. Department of Sciences and Biomedical Technologies, University of Milan, L.I.T.A., Milano 2. Institute of Molecular Bioimaging and Physiology, National Research Council, Milano 3. Department of Surgical Sciences, University of Milano-Bicocca, Milano 4. Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College, London (UK) 5. The Copenhagen Muscle Research Centre and Rigshospitalet section, Copenhagen (Denmark) 6. Department of Sport Science, University of Århus, Århus (Denmark) (literal)
Titolo
  • Proteins modulation in human skeletal muscle in the early phase of adaptation to hypobaric hypoxia. (literal)
Abstract
  • High altitude hypoxia is a paraphysiological condition triggering redox status disturbances of cell organization leading, via oxidative stress, to proteins, lipids, and DNA damage. In man, skeletal muscle, after prolonged exposure to hypoxia, undergoes mass reduction and alterations at the cellular level featuring a reduction of mitochondrial volume density, accumulation of lipofuscin, a product of lipid peroxidation, and dysregulation of enzymes whose time course is unknown. The effects of 7-9 days exposure to 4559 m (Margherita Hut, Monte Rosa, Italy) on the muscle proteins pattern were investigated, pre- and post-exposure, in ten young subjects, by 2-D DIGE and MS. Ten milligram biopsies were obtained from the mid part of the vastus lateralis muscle at sea level (control) and at altitude, after 7-9 days hypoxia. Differential analysis indicates that proteins involved in iron transport, tricarboxylic acid (TCA) cycle, oxidative phosphorylation, and oxidative stress responses were significantly (p<0.05) decreased in hypoxia. Parenthetically, hypoxia markers such as hypoxia inducible factor 1 alpha (HIF-1alpha) and pyruvate dehydrogenase kinase 1 (PDK1) were still at the pre-hypoxia levels, whereas the mammalian target of rapamycin (mTOR), a marker of protein synthesis, was reduced. (literal)
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