Negation in the brain: Modulating action representations (Articolo in rivista)

Type
Label
  • Negation in the brain: Modulating action representations (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Alternative label
  • Tettamanti M. 1,2,3, Manenti R. 2,4, Della Rosa P.A. 2,4, Falini A. 1,4, Perani D. 2,3,4,5, Cappa S.F. 2,3,4, Moro A. 2,4 (2008)
    Negation in the brain: Modulating action representations
    in NeuroImage (Orlando Fla., Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Tettamanti M. 1,2,3, Manenti R. 2,4, Della Rosa P.A. 2,4, Falini A. 1,4, Perani D. 2,3,4,5, Cappa S.F. 2,3,4, Moro A. 2,4 (literal)
Pagina inizio
  • 358 (literal)
Pagina fine
  • 367 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 43 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • Pubblicato on-line: 15 Agosto 2008. Corresponding author: M. Tettamanti (tettamanti.marco@hsr.it). I.F.: 5.694 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1. Scientific Institute San Raffaele, Milano 2. CERMAC-HSR, Milano 3. National Institute of Neuroscience, Torino 4. Vita-Salute San Raffaele University, Milano 5. Institute of Molecular Bioimaging and Physiology, CNR, Segrate (MI) (literal)
Titolo
  • Negation in the brain: Modulating action representations (literal)
Abstract
  • Sentential negation is a universal syntactic feature of human languages that reverses the truth value expressed by a sentence. An intriguing question concerns what brain mechanisms underlie our ability to represent and understand the meaning of negative sentences. We approach this issue by investigating action-related language processing and the associated neural representations. Using functional magnetic resonance imaging we measured brain activity in 18 healthy subjects during passive listening of sentences characterized by a factorial combination of polarity (affirmative vs. negative) and concreteness (action-related vs. abstract). Negation deactivated cortical areas and the left pallidum. Compared to abstract sentences, action-related sentences activated the left-hemispheric action-representation system. Crucially, the polarity by concreteness interactions showed that the activity within the action-representation system was specifically reduced for negative action-related vs. affirmative action-related sentences (compared to abstract sentences). Accordingly, functional integration within this system as measured by Dynamic Causal Modeling was specifically weaker for negative action-related than for affirmative action-related sentences. This modulation of action representations indicates that sentential negation transiently reduces the access to mental representations of the negated information. (literal)
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