Tumour hypoxia imaging with [(18)F]FAZA PET in head and neck cancer patients: a pilot study (Articolo in rivista)

Type
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  • Tumour hypoxia imaging with [(18)F]FAZA PET in head and neck cancer patients: a pilot study (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Alternative label
  • Souvatzoglou M. 1, Grosu A.L. 2, Röper B. 2, Krause B.J. 1, Beck R. 1, Reischl G. 3, Picchio M. 4, Machulla H.J. 3, Wester H.J. 1, Piert M. 1,5 (2007)
    Tumour hypoxia imaging with [(18)F]FAZA PET in head and neck cancer patients: a pilot study
    in European journal of nuclear medicine and molecular imaging (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Souvatzoglou M. 1, Grosu A.L. 2, Röper B. 2, Krause B.J. 1, Beck R. 1, Reischl G. 3, Picchio M. 4, Machulla H.J. 3, Wester H.J. 1, Piert M. 1,5 (literal)
Pagina inizio
  • 1566 (literal)
Pagina fine
  • 1575 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 34 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1. Department of Nuclear Medicine, Technische Universität München, Munich, Germany 2. Radiooncology Department, Technische Universität München, Munich, Germany 3. Radiopharmacy, PET Center, University of Tübingen, Tübingen, Germany 4. Scientific Institute San Raffaele, IBFM-CNR, University Milano-Bicocca, Milan, Italy 5. Present address: Division of Nuclear Medicine, Department of Radiology, University of Michigan Health System, University Hospital B1G505C, 1500 E. Medical Center Drive, Ann Arbor, MI-USA (literal)
Titolo
  • Tumour hypoxia imaging with [(18)F]FAZA PET in head and neck cancer patients: a pilot study (literal)
Abstract
  • Purpose Hypoxia is an important negative prognostic factor for radiation treatment of head and neck cancer. This study was performed to evaluate the feasibility of use of 18F-labelled fluoroazomycin arabinoside ([18F]FAZA) for clinical PET imaging of tumour hypoxia. Methods Eleven patients (age 59.6 ± 9 years) with untreated advanced head and neck cancer were included. After injection of approximately 300 MBq of [18F]FAZA, a dynamic sequence up to 60 min was acquired on an ECAT HR+ PET scanner. In addition, approximately 2 and 4 h p.i., static whole-body PET (n = 5) or PET/CT (n = 6) imaging was performed. PET data were reconstructed iteratively (OSEM) and fused with CT images (either an external CT or the CT of integrated PET/CT). Standardised uptake values (SUVs) and tumour-to-muscle (T/M) ratios were calculated in tumour and normal tissues. Also, the tumour volume displaying a T/M ratio >1.5 was determined. Results Within the first 60 min of the dynamic sequence, the T/M ratio generally decreased, while generally increasing at later time points. At 2 h p.i., the tumour SUVmax and SUVmean were found to be 2.3 ± 0.5 (range 1.5–3.4) and 1.4 ± 0.3 (range 1.0–2.1), respectively. The mean T/M ratio at 2 h p.i. was 2.0 ± 0.3 (range 1.6–2.4). The tumour volume displaying a T/M ratio above 1.5 was highly variable. At 2 h p.i., [18F]FAZA organ distribution was determined as follows: kidney > gallbladder > liver > tumour > muscle > bone > brain > lung. Conclusion [18F]FAZA PET imaging appears feasible in head and neck cancer patients, and the achieved image quality is adequate for clinical purposes. Based on our initial results, [18F]FAZA warrants further evaluation as a hypoxia PET tracer for imaging of cancer. (literal)
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