Detection of Lymph-Node Metastases with Integrated [(11)C]Choline PET/CT in Patients with PSA Failure after Radical Retropubic Prostatectomy: Results Confirmed by Open Pelvic-Retroperitoneal Lymphadenectomy (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Detection of Lymph-Node Metastases with Integrated [(11)C]Choline PET/CT in Patients with PSA Failure after Radical Retropubic Prostatectomy: Results Confirmed by Open Pelvic-Retroperitoneal Lymphadenectomy (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.eururo.2007.03.03 (literal)

Alternative label

• Scattoni V.1, Picchio M. 2, Suardi N. 1, Messa C. 2, Freschi M. 3, Roscigno M. 1, Da Pozzo L. 1, Bocciardi A. 1, Rigatti P. 1, Fazio F. 2 (2007)
  Detection of Lymph-Node Metastases with Integrated [(11)C]Choline PET/CT in Patients with PSA Failure after Radical Retropubic Prostatectomy: Results Confirmed by Open Pelvic-Retroperitoneal Lymphadenectomy
  in European urology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Scattoni V.1, Picchio M. 2, Suardi N. 1, Messa C. 2, Freschi M. 3, Roscigno M. 1, Da Pozzo L. 1, Bocciardi A. 1, Rigatti P. 1, Fazio F. 2 (literal)

Pagina inizio

• 423 (literal)

Pagina fine

• 429 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 52 (literal)

Rivista

• European urology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 7 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 2 (literal)

Note

• PubMe (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Department of Urology, University Vita-Salute, Scientific Institute San Raffaele, Milan, Italy 2. Department of Nuclear Medicine, Scientific Institute San Raffaele, IBFM-CNR, University Milano-Bicocca, Milan, Italy 3. Department of Pathology, University Vita-Salute, Scientific Institute San Raffaele, Milan, Italy (literal)

Titolo

• Detection of Lymph-Node Metastases with Integrated [(11)C]Choline PET/CT in Patients with PSA Failure after Radical Retropubic Prostatectomy: Results Confirmed by Open Pelvic-Retroperitoneal Lymphadenectomy (literal)

Abstract

• OBJECTIVES: To prospectively evaluate the accuracy of integrated [(11)C]choline-PET/CT in the diagnosis of lymph-node recurrence in prostate cancer patients with biochemical failure after surgery. METHODS: Since October 2002, 25 patients with biochemical recurrence (median PSA: 1.98ng/ml), based on evidence of lymph-node metastases on [(11)C]choline-PET/CT scan (21 cases) or conventional imaging (4 cases), were scheduled for either bilateral pelvic (12 cases) or both pelvic and retroperitoneal lymph-node dissection (13 patients). RESULTS: Sixty-three nodal sites were evaluated histologically. The mean number of nodes removed and positive nodes were 21.92+/-16.91 (range: 4-74) and 8.84+/-9.65 (range: 1-31), respectively. Of the four patients with negative [(11)C]choline-PET/CT and positive magnetic resonance, none had nodal metastases. Nineteen of the 21 patients (90%) with positive [(11)C]choline-PET/CT had nodal metastases of prostate adenocarcinoma at histologic evaluation. A lesion-based analysis showed that [(11)C]choline-PET/CT sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 64%, 90%, 86%, 72%, and 77%, respectively. The mean maximum diameter of true positive metastases was larger than false-negative ones (15.0 vs. 6.3mm; p=0.0004). CONCLUSIONS: [(11)C]Choline-PET/CT is an accurate diagnostic tool for the detection of lymph-node metastases of recurrent prostate cancer. The low negative predictive value seems to depend on the limited capability of [(11)C]choline-PET/CT to detect microscopic lesions. The high positive predictive value, even with low PSA values, provides a basis for further treatment decisions. (literal)

Prodotto di

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Imaging molecolare e stadiazione (ME.P03.002.001) (Modulo)

Autore CNR

• FERRUCCIO FAZIO (Unità di personale esterno)
• MARIA PICCHIO (Unità di personale esterno)
• MARIA CRISTINA MESSA (Unità di personale esterno)

Insieme di parole chiave

• Keywords of "Detection of Lymph-Node Metastases with Integrated [(11)C]Choline PET/CT in Patients with PSA Failure after Radical Retropubic Prostatectomy: Results Confirmed by Open Pelvic-Retroperitoneal Lymphadenectomy" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• MARIA CRISTINA MESSA (Unità di personale esterno)
• MARIA PICCHIO (Unità di personale esterno)
• FERRUCCIO FAZIO (Unità di personale esterno)

Prodotto

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Imaging molecolare e stadiazione (ME.P03.002.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• European urology (Rivista)

Insieme di parole chiave di

• Keywords of "Detection of Lymph-Node Metastases with Integrated [(11)C]Choline PET/CT in Patients with PSA Failure after Radical Retropubic Prostatectomy: Results Confirmed by Open Pelvic-Retroperitoneal Lymphadenectomy" (Insieme di parole chiave)