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PET evidence of central GABAergic changes in stiff-person syndrome. (Articolo in rivista)

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PET evidence of central GABAergic changes in stiff-person syndrome. (Articolo in rivista) (literal)

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Perani D. 1,2, Garibotto V. 2,3, Panzacchi A. 2, Moresco R.M., 2,3,4, Ortelli P. 2, Corbo M. 5, Fazio F, 2,3,4, Folli F 6. (2007)
PET evidence of central GABAergic changes in stiff-person syndrome.
in Movement disorders
(literal)

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Perani D. 1,2, Garibotto V. 2,3, Panzacchi A. 2, Moresco R.M., 2,3,4, Ortelli P. 2, Corbo M. 5, Fazio F, 2,3,4, Folli F 6. (literal)

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1. Istituto Nazionale di Neuroscienze, Vita-Salute San Raffaele University, Milan, Italy 2. Scientific Institute San Raffaele, Department of Nuclear Medicine, Milan, Italy 3. Milano-Bicocca University, Department of Nuclear Medicine, Milan, Italy 4. Consiglio Nazionale delle Ricerche, Istituto di Bioimmagini e Fisiologia Molecolare, Milan, Italy 5. University of Milan Medical School, IRCCS Istituto Auxologico Italiano, Department of Neurology, Milan, Italy 6. Division of Diabetes, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA (literal)

Titolo

Abstract

We measured expression of central nervous system GABA-A receptors with (11)C-flumazenil ((11)C-FMZ) and PET in two subjects with stiff person syndrome (SPS). We found reduced (11)C-FMZ binding potential (BP) in motor-premotor cortex, and increased (11)C-FMZ BP in the cerebellar nuclei. This is the first in vivo PET evidence of central GABA-A receptors dysfunction in SPS, possibly concurring to the motor symptoms. (literal)

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