Metabolic Modulation Induced by Chronic Hypoxia in rats using a comparative proteomic analysis of skeletal muscle tissue. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Metabolic Modulation Induced by Chronic Hypoxia in rats using a comparative proteomic analysis of skeletal muscle tissue. (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Alternative label

• De Palma S.D. 1,3, Ripamonti M. 2, Vigano A. 3, Moriggi M. 3, Capitanio D. 3, Samaja M. 4, Milano G. 5, Cerretelli P. 3, Wait R. 6, Gelfi C. 2,3 (2007)
  Metabolic Modulation Induced by Chronic Hypoxia in rats using a comparative proteomic analysis of skeletal muscle tissue.
  in Journal of proteome research (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• De Palma S.D. 1,3, Ripamonti M. 2, Vigano A. 3, Moriggi M. 3, Capitanio D. 3, Samaja M. 4, Milano G. 5, Cerretelli P. 3, Wait R. 6, Gelfi C. 2,3 (literal)

Pagina inizio

• 1974 (literal)

Pagina fine

• 1984 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 6 (literal)

Rivista

• Journal of proteome research (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Department of Surgical Sciences, University of Milano-Bicocca, Italy, 2. Institute of Molecular Imaging and Physiology, National Research Council, Segrate, Italy, 3. Department of Sciences and Biomedical Technologies, University of Milan, L.I.T.A., Segrate, Italy, 4. Department of Medicine, Surgery and Dentistry, University of Milan, San Paolo Hospital, Milan, Italy, 5. Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland 6. Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College, London, United Kingdom (literal)

Titolo

• Metabolic Modulation Induced by Chronic Hypoxia in rats using a comparative proteomic analysis of skeletal muscle tissue. (literal)

Abstract

• Hypoxia-induced changes of rat skeletal muscle were investigated by two-dimensional difference in-gel electrophoresis (2D-DIGE) and mass spectrometry. The results indicated that proteins involved in the TCA cycle, ATP production, and electron transport are down-regulated, whereas glycolytic enzymes and deaminases involved in ATP and AMP production were up-regulated. Up-regulation of the hypoxia markers hypoxia inducible factor 1 (HIF-1alpha) and pyruvate dehydrogenase kinase 1 (PDK1) was also observed, suggesting that in vivo adaptation to hypoxia requires an active metabolic switch. The kinase protein, mammalian target of rapamycin (mTOR), which has been implicated in the regulation of protein synthesis in hypoxia, appears unchanged, suggesting that its activity, in this system, is not controlled by oxygen partial pressure. Keywords: skeletal muscle * hypoxia * 2D-DIGE * mass spectrometry. (literal)

Prodotto di

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Genomica e proteomica per la ricerca di biomarcatori in malattie neurodegenerative e nei tumori (ME.P05.002.001) (Modulo)

Autore CNR

• MARILENA RIPAMONTI (Persona)
• CECILIA GELFI (Unità di personale interno)
• PAOLO CERRETELLI (Unità di personale esterno)

Insieme di parole chiave

• Parole chiave di "Metabolic Modulation Induced by Chronic Hypoxia in rats using a comparative proteomic analysis of skeletal muscle tissue." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• CECILIA GELFI (Unità di personale interno)
• MARILENA RIPAMONTI (Persona)
• PAOLO CERRETELLI (Unità di personale esterno)

Prodotto

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Genomica e proteomica per la ricerca di biomarcatori in malattie neurodegenerative e nei tumori (ME.P05.002.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of proteome research (Rivista)

Insieme di parole chiave di

• Parole chiave di "Metabolic Modulation Induced by Chronic Hypoxia in rats using a comparative proteomic analysis of skeletal muscle tissue." (Insieme di parole chiave)