Impaired oxygen extraction in metabolic myopathies: detection and quantification by near-infrared spectroscopy. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Impaired oxygen extraction in metabolic myopathies: detection and quantification by near-infrared spectroscopy. (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Alternative label

• Grassi B. 1,2, Marzorati M. 2, Lanfranconi F. 1, Ferri A. 1, Longaretti M. 1, Stucchi A. 1, Vago P. 1, Marconi C. 2, Morandi L. 3 (2007)
  Impaired oxygen extraction in metabolic myopathies: detection and quantification by near-infrared spectroscopy.
  in Muscle & nerve (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Grassi B. 1,2, Marzorati M. 2, Lanfranconi F. 1, Ferri A. 1, Longaretti M. 1, Stucchi A. 1, Vago P. 1, Marconi C. 2, Morandi L. 3 (literal)

Pagina inizio

• 510 (literal)

Pagina fine

• 520 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 35 (literal)

Rivista

• Muscle & nerve (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Department of Science and Biomedical Technologies, University of Milan, LITA, Segrate (MI), Italy 2. Institute of Bioimaging and Molecular Physiology, CNR, Segrate (MI), Italy 3. Department of Neuromuscular Diseases, Neurological Institute Carlo Besta, Milan, Italy (literal)

Titolo

• Impaired oxygen extraction in metabolic myopathies: detection and quantification by near-infrared spectroscopy. (literal)

Abstract

• Patients with mitochondrial myopathies (MM) or myophosphorylase deficiency (McArdle's disease, McA) show impaired capacity for O(2) extraction, low maximal aerobic power, and reduced exercise tolerance. Non-invasive tools are needed to quantify the metabolic impairment. Six patients with MM, 6 with McA, 25 with symptoms of metabolic myopathy but negative biopsy (patient-controls, P-CTRL) and 20 controls (CTRL) underwent an incremental cycloergometric test. Pulmonary O(2) uptake (VO(2)) and vastus lateralis oxygenation indices (by near-infrared spectroscopy, NIRS) were determined. Concentration changes of deoxygenated hemoglobin and myoglobin (Delta[deoxy(Hb + Mb)]) were considered an index of O(2) extraction. Delta[deoxy(Hb + Mb)] peak (percent limb ischemia) was lower in MM (25.3 +/- 12.0%) and McA (18.7 +/- 7.3) than in P-CTRL (62.4 +/- 3.9) and CTRL (71.3 +/- 3.9) subjects. VO(2) peak and Delta[deoxy(Hb + Mb)] peak were linearly related (r(2) = 0.83). In these patients, NIRS is a tool to detect and quantify non-invasively the metabolic impairment, which may be useful in the follow-up of patients and in the assessment of therapies and interventions. (literal)

Prodotto di

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Fattori cardiovascolari e muscolari limitanti l'esercizio: ambiente e stress ossidativo (ME.P01.002.001) (Modulo)

Autore CNR

• BRUNO GRASSI (Persona)
• MAURO MARZORATI (Unità di personale interno)
• CLAUDIO MARCONI (Persona)

Insieme di parole chiave

• Keywords of "Impaired oxygen extraction in metabolic myopathies: detection and quantification by near-infrared spectroscopy." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• CLAUDIO MARCONI (Persona)
• MAURO MARZORATI (Unità di personale interno)
• BRUNO GRASSI (Persona)

Prodotto

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Fattori cardiovascolari e muscolari limitanti l'esercizio: ambiente e stress ossidativo (ME.P01.002.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Muscle & nerve (Rivista)

Insieme di parole chiave di

• Keywords of "Impaired oxygen extraction in metabolic myopathies: detection and quantification by near-infrared spectroscopy." (Insieme di parole chiave)