http://www.cnr.it/ontology/cnr/individuo/prodotto/ID102997
Obstructive sleep apnea does not affect circulating hematopoietic precursors. (Abstract/Poster in atti di convegno)
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- Label
- Obstructive sleep apnea does not affect circulating hematopoietic precursors. (Abstract/Poster in atti di convegno) (literal)
- Anno
- 2005-01-01T00:00:00+01:00 (literal)
- Alternative label
Bonsignore MR; Marrone O; Santoro A; Salvaggio A; Marfia A; Gioia M; Bonanno A; Riccobono L; Profita M; Mirabella A; Bonsignore G; Bellia V (2005)
Obstructive sleep apnea does not affect circulating hematopoietic precursors.
in XV congresso annuale della European Respiratory Society, Copenhagen (DK), 17-20 settembre 2005
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- Bonsignore MR; Marrone O; Santoro A; Salvaggio A; Marfia A; Gioia M; Bonanno A; Riccobono L; Profita M; Mirabella A; Bonsignore G; Bellia V (literal)
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- Istituto di Biomedicina e Immunologia Molecolare CNR, Palermo, Italy; (literal)
- Titolo
- Obstructive sleep apnea does not affect circulating hematopoietic precursors. (literal)
- Abstract
- Little is known on the effects of intermittent hypoxia on circulating hematopoietic precursors (CD34+ cells) in the obstructive sleep apnea syndrome (OSAS). We studied circulating CD34+ cells (myeloid precursors) and CD61+ cells (platelet precursors) by flow cytometry in controls (n=10; age: 44.1±4.9 yrs; BMI: 27.2±3.7 kg/m²) and in patients with untreated OSAS of variable severity (n=26, age: 49.1±6.2 yrs; BMI: 33.5±4.3 kg/m²; AHI: 56.7±29.9/h; SaO2 73.1±15.3%; time at SaO2<90%: 25.2±26.8%), after one night of CPAP treatment (n=13), and after prolonged CPAP treatment (n=7). Blood cell counts and plasma concentration of flt3-ligand, a hematopoietic growth factor, were also measured. The only difference between OSAS patients and control was a slight increase in CD34+ cell counts under no treatment in OSAS (10.3±12.0 vs. 5.0±2.8 cells/µL in controls, p<0.05 by Wilcoxon test). flt3-ligand concentration was similar in patients and controls (OSAS: 90±25; controls: 84±24 µg/mL), and increased with BMI in OSAS patients (r=0.46, p<0.05). No correlation was found between CD34+ cell counts and severity of OSAS, assessed as AHI, mean lowest SaO2 or time spent at SaO2<90%. Therefore, OSAS exerts small or no effect on circulating precursors. (literal)
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