Bone metastases are infrequent in patients with newly diagnosed prostate cancer: analysis of their clinical and pathologic features (Articolo in rivista)

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  • Bone metastases are infrequent in patients with newly diagnosed prostate cancer: analysis of their clinical and pathologic features (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Alternative label
  • Salonia A. 1, Gallina A. 1, Camerota T.C. 1, Picchio M. 2, Freschi M. 3, DaPozzo L.F. 1, Guazzoni G. 1, Fazio F. 2, Rigatti P.1, Montorsi F. 1 (2006)
    Bone metastases are infrequent in patients with newly diagnosed prostate cancer: analysis of their clinical and pathologic features
    in Urology (Ridgewood N.J.)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Salonia A. 1, Gallina A. 1, Camerota T.C. 1, Picchio M. 2, Freschi M. 3, DaPozzo L.F. 1, Guazzoni G. 1, Fazio F. 2, Rigatti P.1, Montorsi F. 1 (literal)
Pagina inizio
  • 362 (literal)
Pagina fine
  • 366 (literal)
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  • 68 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1. Department of Urology, University Vita-Salute San Raffaele, Scientific Institute San Raffaele Hospital, Milan, Italy 2. IBFM CNR, University Milano Bicocca, Scientific Institute San Raffaele Hospital, Milan, Italy 3. Department of Pathology, University Vita-Salute San Raffaele, Scientific Institute San Raffaele Hospital, Milan, Italy (literal)
Titolo
  • Bone metastases are infrequent in patients with newly diagnosed prostate cancer: analysis of their clinical and pathologic features (literal)
Abstract
  • OBJECTIVES: To investigate the clinical and pathologic characteristics of patients with bone metastases identified at the time of newly diagnosed prostate carcinoma at biopsy. METHODS: From November 2002 to May 2004, 1587 consecutive patients had a pathologic diagnosis of prostate cancer and underwent conventional technetium-99m methylene diphosphonate scintigraphy of the entire body. The clinical and pathologic features of those patients with positive bone scan findings (group 1) were compared with those of a subcohort of 372 patients with negative bone scan findings performed at the same nuclear medicine department (group 2). RESULTS: A retrospective complete data collection was available for 1242 of 1587 patients. Bone metastases were found in 31 patients (2.5%). As expected, patients with skeletal metastases had a significantly greater mean serum total prostate-specific antigen level, and a Gleason sum of 8 or 9 was significantly more frequent in the pathologic findings of these subjects. Group 1 patients had a significantly greater prevalence of previous nonprostate primary neoplasms (chi-square 12.74, df = 1, P = 0.0004) and reported a greater prevalence of current use of H2 blockers for the treatment and prevention of gastroesophageal reflux disorders (chi-square 37.52, df = 1, P < 0.0001) than did group 2 patients. CONCLUSIONS: Our data have confirmed that bone metastases are more frequent in patients with high prostate-specific antigen levels and poorly differentiated tumors at biopsy regardless of the patient's age. A history of previous nonprostate primary neoplasms and the use of H2 blockers seemed to be more prevalent in those patients with bone metastases at diagnosis. (literal)
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