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Cerebral D2 and 5HT2 receptor occupancy in schizophrenic patients treated with olanzapine or clozapine (Articolo in rivista)

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Cerebral D2 and 5HT2 receptor occupancy in schizophrenic patients treated with olanzapine or clozapine (Articolo in rivista) (literal)

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Moresco R.M. 1, Cavallaro R. 2, Messa C. 1, Bravi D. 3, Gobbo C. 1, Galli L. 4, Lucignani G. 5, Colombo C. 2, Rizzo G. 1, Velonà I. 3, Smeraldi E. 2, Fazio F. 1 (2004)
Cerebral D2 and 5HT2 receptor occupancy in schizophrenic patients treated with olanzapine or clozapine
in Journal of psychopharmacology (Oxf.)
(literal)

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Moresco R.M. 1, Cavallaro R. 2, Messa C. 1, Bravi D. 3, Gobbo C. 1, Galli L. 4, Lucignani G. 5, Colombo C. 2, Rizzo G. 1, Velonà I. 3, Smeraldi E. 2, Fazio F. 1 (literal)

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This article has been cited 11 times in Web of Knowledge. This article has been cited 9 times in Scopus (literal)

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1. IBFM-CNR, Department of Nuclear Medicine, University of Milan-Bicocca, San Raffaele Scientific Institute, Milan, Italy. 2. Department of Psychiatry, Vita-Salute S. Raffaele University, San Raffaele Scientific Institute Hospital, Milan, Italy. 3. Medical Division Eli Lilly S.p.A Sesto Fiorentino, Italy. 4. San Raffaele Scientific Institute, Milan, Italy. 5. Institute of Radiological Sciences, University of Milan, Ospedale Luigi Sacco, Milan, Italy. (literal)

Titolo

Cerebral D2 and 5HT2 receptor occupancy in schizophrenic patients treated with olanzapine or clozapine (literal)

Abstract

We report the results of a double-blind, randomized prospective trial on D2 and 5-HT2 receptor occupancy and the clinical effects of olanzapine versus clozapine in a sample of neuroleptic-refractory schizophrenic patients. Receptor occupancy was evaluated in different cortical areas and in basal ganglia using [18F] fluoro-ethyl-spiperone ([18F] FESP) and positron emission tomography (PET). A total of 15 neuroleptic-free patients completed the study undergoing a baseline and a post-treatment PET scan (olanzapine, nine patients, one female; clozapine, six patients, three female) 8 weeks after starting treatment. PET data were analysed both by regions of interest and on a voxel-by-voxel basis using Statistical Parametric Mapping (SPM96). Olanzapine and clozapine induced a similar and significant inhibition of [18F] FESP binding index in the cortex. In the basal ganglia, receptor occupancy was significantly higher with olanzapine than with clozapine (p=0.0018). By contrast, no differences in receptor occupancy were detected at the level of the pituitary gland. Clinical outcomes, in particular a full extra pyramidal tolerability, were similar. In this sample of neuroleptic-refractory schizophrenic patients, olanzapine and clozapine showed a different pattern of occupancy of D2-like receptor despite a common lack of extrapyramidal side-effects. (literal)

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