Feasibility of [18F]FDG-PET and co-registered CT on clinical target volume definition of advanced non-small cell lung cancer. (Articolo in rivista)

Type
Label
  • Feasibility of [18F]FDG-PET and co-registered CT on clinical target volume definition of advanced non-small cell lung cancer. (Articolo in rivista) (literal)
Anno
  • 2005-01-01T00:00:00+01:00 (literal)
Alternative label
  • Messa C. 1,2,3, Ceresoli G.L. 4, Rizzo G. 2,3, Artioli D. 1, Cattaneo M,. 5 Castellone P. 5, Gregorc V. 4, Picchio M. 3, Landoni C. 1,3, Fazio F. 1,2,3,4 (2005)
    Feasibility of [18F]FDG-PET and co-registered CT on clinical target volume definition of advanced non-small cell lung cancer.
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Messa C. 1,2,3, Ceresoli G.L. 4, Rizzo G. 2,3, Artioli D. 1, Cattaneo M,. 5 Castellone P. 5, Gregorc V. 4, Picchio M. 3, Landoni C. 1,3, Fazio F. 1,2,3,4 (literal)
Pagina inizio
  • 259 (literal)
Pagina fine
  • 266 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 49 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • I.F:: 1.567 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1. DNTB, School of Medicine, University of Milano-Bicocca, Milan, Italy 2. Institute for Molecular Bioimaging and Physiology-CNR, Milan, Italy 3. Department of Nuclear Medicine, Scientific Institute H S. Raffaele, Milan, Italy 4. Department of Radiation Oncology and Clinical Oncology, Scientific Institute H S. Raffaele, Milan, Italy 5. Department of Radiation Physics, Scientific Institute H S. Raffaele, Milan, Italy (literal)
Titolo
  • Feasibility of [18F]FDG-PET and co-registered CT on clinical target volume definition of advanced non-small cell lung cancer. (literal)
Abstract
  • AIM: To prospectively evaluate the impact of coregistered positron emission tomography (PET) and computed tomography (CT) in 3D conformal radiotherapy (3D-CRT) planning in patients with non-small lung cancer (NSCLC). METHODS: Twenty-one patients (median age: 57 years; range: 42-80 years) referred to 3D-CRT for NSCLC were recruited. Positron emission tomography with 18F-fluorodeoxyglucose ([18F]FDG-PET) and conventional CT images were coregistered (PET/CT images) using a commercial software package based on surface matching technique. Neoplastic areas were contoured on [18F]FDG-PET images with the aid of the correspondent CT image by a nuclear medicine physician. CT images and their relative PET contours were then transferred to treatment planning system. A radiation oncologist firstly contoured clinical target volumes (CTV) on CT scan alone (CTV-CT), and then on coregistered PET/CT images (CTV-PET/CT). CTV-CT and CTV-PET/CT were compared for each patient; a difference higher than 25% was considered of clinical relevance. RESULTS: Three patients were shifted to palliative radiotherapy for metastatic disease or very large tumor size, showed by [18F]FDG-PET. Of the remaining 18 patients a CTV change, after inclusion of PET/CT data, was observed in 10/18 cases (55%): larger in 7/18 (range 33-279%) and smaller in 3/18 patients (range 26-34%), mainly due to inclusion or exclusion of lymph-nodal disease and to better definition of tumor extent. CTV changes smaller than 25% occurred in the remaining 8/18 patients. CONCLUSIONS: [18F]FDG-PET and CT images co-registration in radiotherapy treatment planning led to a change in CTV definition in the majority of our patients, which may significantly modify management and radiation treatment modality in these patients. (literal)
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