http://www.cnr.it/ontology/cnr/individuo/prodotto/ID10156

Target delineation in post-operative radiotherapy of brain gliomas: interobserver variability and impact of image registration of MR (pre-operative) images on treatment planning CT scans. (Articolo in rivista)

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Target delineation in post-operative radiotherapy of brain gliomas: interobserver variability and impact of image registration of MR (pre-operative) images on treatment planning CT scans. (Articolo in rivista) (literal)

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Cattaneo G.M. 1, Reni M. 2, Rizzo G. 3, Castellone P. 4, Ceresoli G.L. 2, Cozzarini C. 2, Ferreri A.J.M. 2, Passoni P. 2, Calandrino R. 1 (2005)
Target delineation in post-operative radiotherapy of brain gliomas: interobserver variability and impact of image registration of MR (pre-operative) images on treatment planning CT scans.
in Radiotherapy and oncology
(literal)

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Cattaneo G.M. 1, Reni M. 2, Rizzo G. 3, Castellone P. 4, Ceresoli G.L. 2, Cozzarini C. 2, Ferreri A.J.M. 2, Passoni P. 2, Calandrino R. 1 (literal)

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Lo studio esamina la variabilità interosservatore nella delineazione di tumore intracranico su immagini CT, nel caso di uso di hardcopy MR pre-operatorie o di immagini MR preoperatorie registrate alle CT. La registrazione è ottenuta usando una tecnica di minimizzazione di distanze tra superfici equivalenti, con accuratezza stimata inferiore ai 4mm. Lindice di concordanza tra osservatori si è rivelato significativamente migliore nel caso di uso di immagini integrate. (literal)

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1. Medical Physics, Scientific Institute, H.S. Raffaele, Milano, Italy, 2. Radiochemotherapy, Scientific Institute, H.S. Raffaele, Milano, Italy, 3. IBFM-CNR, Nuclear Medicine, Scientific Institute, H.S. Raffaele, Milano, Italy, 4. Physics Department, University of Napoli Federico II, Napoli, Italy (literal)

Titolo

Target delineation in post-operative radiotherapy of brain gliomas: interobserver variability and impact of image registration of MR (pre-operative) images on treatment planning CT scans. (literal)

Abstract

BACKGROUND AND PURPOSE: To investigate the interobserver variability of intracranial tumour delineation on computed tomography (CT) scans using pre-operative MR hardcopies (CT+MR(conv)) or CT-MR (pre-operative) registered images (CT+MR(matched)). PATIENTS AND METHODS: Five physicians outlined the 'initial' clinical tumour volume (CTV0) of seven patients affected by HGG and candidates for radiotherapy (RT) after radical resection. The observers performed on screen-tumour delineation using post-operative CT images of the patients in the treatment position and pre-operative MR radiographs (CT+MR(conv)); they also outlined CTV0 with both CT and corresponding MR axial image on screen (CT+MR(matched)). The accuracy of the image fusion was quantitatively assessed. An analysis was conducted to assess the variability among the five observers in CT+MR(conv) and CT+MR(matched) modality. RESULTS: The registration accuracy in 3D space is always less than 3.7 mm. The concordance index was significantly better in CT+MR(matched) (47.4+/-12.4%) than in CT+MR(conv) (14.1+/-12.7%) modality (P<0.02). The intersecting volumes represent 67+/-15 and 24+/-18% of the patient mean volume for CT+MR(matched) and CT+MR(conv), respectively (P<0.02). CONCLUSIONS: The use of CT and MR registered imaging reduces interobserver variability in target volume delineation for post-operative irradiation of HGG; smaller margins around target volume could be adopted in defining irradiation technique. (literal)

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