Lesion detectability and quantification in PET/CT oncological studies by Monte Carlo simulations (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Lesion detectability and quantification in PET/CT oncological studies by Monte Carlo simulations (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1109/TNS.2005.844018 (literal)

Alternative label

• Castiglioni I. 1, Rizzo G. 1, Gilardi M.C. 1, Bettinardi V. 1, Savi A. 1, Fazio F. 1 (2005)
  Lesion detectability and quantification in PET/CT oncological studies by Monte Carlo simulations
  in IEEE transactions on nuclear science
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Castiglioni I. 1, Rizzo G. 1, Gilardi M.C. 1, Bettinardi V. 1, Savi A. 1, Fazio F. 1 (literal)

Pagina inizio

• 136 (literal)

Pagina fine

• 142 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 52 (literal)

Rivista

• IEEE transactions on nuclear science (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. IBFM-CNR, University of Milan-Bicocca, Scientific Institute H. S. Raffaele, Milan, Italy (literal)

Titolo

• Lesion detectability and quantification in PET/CT oncological studies by Monte Carlo simulations (literal)

Abstract

• The aim of this work was to assess lesion detectability and quantification in whole body oncological 18F-FDG studies performed by a state-of-the-art integrated Positron Emission Tomograph/computed tomography (PET/CT) system. Lesion detectability and quantification were assessed by a Monte Carlo (MC) simulation approach as a function of different physical factors (e.g., attenuation and scatter), image counting statistics, lesion size and position, lesion-to-background radioactivity concentration ratio (L/B), and reconstruction algorithms. The results of this work brought to a number of conclusions. • The MC code PET-electron gamma shower (EGS) was accurate in simulating the physical response of the considered PET/CT scanner (90%). • PET-EGS and patient-derived phantoms can be used in simulating18 F-FDG PET oncological studies. • Counting statistics is a dominant factor in lesion detectability. • Correction for scatter (from both inside and outside the field of view) is needed to improve lesion detectability. • Iterative reconstruction and attenuation correction must be used to interpret clinical images. • Re-binning algorithms are appropriate for whole-body oncological data. • A MC-based method for correction of partial volume effect is feasible. For the considered PET/CT system, limits in lesion detectability were determined in situations comparable to those of real oncological studies: at a L B = 3 for lesions of 12 mm diameter and at a L B = 4 for lesions of 8 mm diameter. (literal)

Prodotto di

• Tecniche terapeutiche innovative (ME.P06.005.001) (Modulo)
• Institute of molecular bioimaging and physiology (IBFM) (Istituto)

Autore CNR

• ISABELLA CASTIGLIONI (Persona)
• GIOVANNA RIZZO (Persona)

Insieme di parole chiave

• Keywords of "Lesion detectability and quantification in PET/CT oncological studies by Monte Carlo simulations" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• GIOVANNA RIZZO (Persona)
• ISABELLA CASTIGLIONI (Persona)

Prodotto

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Tecniche terapeutiche innovative (ME.P06.005.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• IEEE transactions on nuclear science (Rivista)

Insieme di parole chiave di

• Keywords of "Lesion detectability and quantification in PET/CT oncological studies by Monte Carlo simulations" (Insieme di parole chiave)