Value of [11C]choline PET in re-staging prostate cancer: A comparison with [18F]FDG-PET. (Articolo in rivista)

Type
Label
  • Value of [11C]choline PET in re-staging prostate cancer: A comparison with [18F]FDG-PET. (Articolo in rivista) (literal)
Anno
  • 2003-01-01T00:00:00+01:00 (literal)
Alternative label
  • Picchio M. 1, Messa C. 1,2,3, Landoni C. 1,2, Gianolli L.1, Sironi S. 2,3, Brioschi M. 2, Matarrese M. 3, Matei D.V. 4, De Cobelli F. 5, Del Maschio A. 5, Rocco F. 6, Rigatti P.7, Fazio F. 1,2,3 (2003)
    Value of [11C]choline PET in re-staging prostate cancer: A comparison with [18F]FDG-PET.
    (literal)
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  • Picchio M. 1, Messa C. 1,2,3, Landoni C. 1,2, Gianolli L.1, Sironi S. 2,3, Brioschi M. 2, Matarrese M. 3, Matei D.V. 4, De Cobelli F. 5, Del Maschio A. 5, Rocco F. 6, Rigatti P.7, Fazio F. 1,2,3 (literal)
Pagina inizio
  • 1337 (literal)
Pagina fine
  • 1340 (literal)
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  • Impact factor: J Urology: 3. Pochi lavori esistenti che utilizzino lo stesso metodo, tanto che il lavoro viene richiesto in vari convegni sull’argomento. (literal)
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  • 169 (literal)
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  • Citazioni al 26/01/09: 74 Citazioni al 2007 (escluso autocitazioni): 44 (literal)
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  • Primo lavoro in pazienti in ristadiazione per sospetta recidiva dopo trattamento radicale per neoplasia prostatica. Messa a punto di un metodo PET alternativo, che non utilizza il tracciante convenzionale (FDG) ma un tracciante alternativo (Colina), più sensibile anche a i gradi più bassi di neoplasie. (literal)
Note
  • ISI Web of Science (WOS) (literal)
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  • 1. Department of Nuclear Medicine, Institute H San Raffaele, Milan, Italy 2. University of Milano-Bicocca, Milan, Italy 3. CNR, Institute for Molecular Bioimaging and Phisiology, Milan, Italy 4. Division of Urology, European Institute for Oncology, Milan, Italy 5. Department of Radiology, Institute H San Raffaele, Milan, Italy 6. Division of Urology, University of Milan, H San Paolo, Milan, Italy 7. Department of Urology, Institute H San Raffaele, Milan, Italy (literal)
Titolo
  • Value of [11C]choline PET in re-staging prostate cancer: A comparison with [18F]FDG-PET. (literal)
Abstract
  • PURPOSE: We compared [11C]choline-positron emission tomography (PET) with [18F]fluorodeoxyglucose-PET for re-staging prostate cancer in a group of 100 patients. MATERIALS AND METHODS: A total of 100 consecutive patients referred for whole body [18F]fluorodeoxyglucose-PET for clinical prostate re-staging after radical treatment for prostate cancer were retrospectively included in the study. Mean prostate specific antigen (PSA) was 6.57 ng./ml. In all cases [11C]choline-PET was also performed. PET studies were done with a multiring device 5 minutes after intravenous injection of approximately 370 MBq. [11C]choline and 60 minutes after injection of approximately 370 MBq. [18F]fluorodeoxyglucose. PET findings were compared with those obtained with different conventional imaging and with PSA assessed at the time of PET and 1 year later. RESULTS: Areas of abnormal focal increases were noted in 47% of patients on [11C]choline-PET and in 27% on [18F]fluorodeoxyglucose-PET. Of the 100 patients 49 had positive conventional imaging findings. All except 14 [11C]choline-PET findings were concordant with conventional imaging, including 6 negative and 8 positive conventional imaging results. All except 1 [11C]choline-PET negative cases also had negative conventional imaging after 1 year. PSA at 1 year remained stable or decreased in 80% and 62% of [11C]choline-PET negative and positive cases, respectively. CONCLUSIONS: [11C]choline-PET seems to be useful for re-staging prostatectomy cases with increasing serum PSA levels. It is superior to [18F]fluorodeoxyglucose-PET and complementary to conventional imaging but with the advantage of staging disease at a single step. (literal)
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