http://www.cnr.it/ontology/cnr/individuo/unitaDiPersonaleInterno/MATRICOLA8735
GIOVANNI MAGA
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- GIOVANNI MAGA (literal)
- GIOVANNI MAGA (literal)
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- The Arabidopsis STRESS RESPONSE SUPPRESSOR DEAD-box RNA helicases are nucleolar- and chromocenter-localized proteins that undergo stress-mediated relocalization and are involved in epigenetic gene silencing (Articolo in rivista) (Prodotto della ricerca)
- Enzymes of DNA metabolism in a patient with the Wiedemann-Rautenstrauch progeroid syndrome. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- 5-Iodo-2'-deoxy-L-uridine and (E)-5-(2-bromovinyl)-2'-deoxy-L-uridine: selective phosphorylation by herpes simplex virus type 1 thymidine kinase, antiherpetic activity, and cytotoxicity studies. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Lack of stereospecificity of some cellular and viral enzymes involved in the synthesis of deoxyribonucleotides and DNA: molecular basis for the antiviral activity of unnatural L-beta-nucleosides. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Kinetic studies with N2-phenylguanines and with L-thymidine indicate that herpes simplex virus type-1 thymidine kinase and thymidylate kinase share a common active site. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Aphidicolin inhibits in vitro the activity of pseudorabies virus (PRV) DNA polymerase and in vivo the viral proliferation. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Stereospecificity of human DNA polymerases alpha, beta, gamma, delta and epsilon, HIV-reverse transcriptase, HSV-1 DNA polymerase, calf thymus terminal transferase and Escherichia coli DNA polymerase I in recognizing D- and L-thymidine 5'-triphosphate as substrate. (Articolo in rivista) (Prodotto della ricerca)
- Novel host-pathogen interactions between human proteins and NS1 of epidemic avian influenza virus (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Targeting host-pathogen interactions in viral infections as a novel therapeutic strategy: lessons from cancer research (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- 6-Vinyl pyrimidine and pyrimidinone derivatives and the use thereof. (Brevetto) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1601)
- LACK OF STEREOSPECIFICITY OF SUID PSEUDORABIES VIRUS THYMIDINE KINASE (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- DNA polymerases as anticancer drug targets (Comunicazione a convegno) (Prodotto della ricerca)
- Interazione diretta tra PARP1, PCNA e p21: un possibile ruolo nella regolazione di PCNA nella riparazione del DNA (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- La proteina Vif del virus HIV-1 e un fattore accessorio per la trascrittasi inversa (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Role of the HIV-1 auxiliary protein Vif in the retrotranscription process (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- DNA polymerase lambda: a molecular Swiss army knife (Comunicazione a convegno) (Prodotto della ricerca)
- Arylthiopyrrole (ATP) Derivatives as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Diketo hexenoic acid (DKHA) derivatives: the first class of selective non-nucleoside inhibitors of mammalian terminal deoxynucleotidyl transferases endowed with cytotoxic effect against leukemic cells. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Tyrosine Kinase inhibitors active against a wide panel of tumor cell lines. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Indolylarylsulfones Bearing Natural and Unnatural Amino Acids. Discovery of Potent Inhibitors of HIV-1 Non-Nucleoside Wild Type and Resistant Mutant Strains Reverse Transcriptase and Coxsackie B4 Virus (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Expression, characterization of human DDX3 protein and construction of mutants. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Natural resistance to HIV infection: role of APOBEC. (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- DNA polymerases and Diseases. (Articolo in rivista) (Prodotto della ricerca)
- Repair and translesion DNA polymerases as anticancer drug targets. (Articolo in rivista) (Prodotto della ricerca)
- Roles of the human proteins PCNA, RP-A and Fen-1 in avoiding functional redundance between human DNA polymerases b and l in genomic stability safeguarding. (Comunicazione a convegno) (Prodotto della ricerca)
- Silencing of human DNA polymerase lambda causes replication stress and is synthetically lethal with an impaired S phase checkpoint. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- DNA polymerases and Diseases (Monografia o trattato scientifico) (Prodotto della ricerca)
- A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Intrinsic and extrinsic determinants of DNA polymerases fidelity in normal and translesion synthesis (Contributo in volume (capitolo o saggio)) (Prodotto della ricerca)
- DNA polymerases: discovery, characterization and functions in cellular DNA transactions (Monografia o trattato scientifico) (Prodotto della ricerca)
- Inhibitors of human immunodeficiency virus-1 replication targeting the human dead-box polypeptide 3 (DDX3) RNA helicase (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Selective interaction of the human immunodeficiency virus type 1 reverse transcriptase nonnucleoside inhibitor efavirenz and its thio-substituted analog with different enzyme-substrate complexes (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Electron microscopic analysis reveals that replication factor C is sequestered by single-stranded DNA (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Solid phase synthesis of 2,6-disubstituted-4(3H)-pyrimidinones targeting HIV-1 reverse transcriptase (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- DNA polymerase lambda from calf thymus preferentially replicates damaged DNA. (Articolo in rivista) (Prodotto della ricerca)
- Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis. (Articolo in rivista) (Prodotto della ricerca)
- The RNA helicase, nucleotide 5'-triphosphatase, and RNA 5'-triphosphatase activities of Dengue virus protein NS3 are Mg2+-dependent and require a functional Walker B motif in the helicase catalytic core. (Articolo in rivista) (Prodotto della ricerca)
- The human DNA polymerase lambda interacts with PCNA through a domain important for DNA primer binding and the interaction is inhibited by p21/WAF1/CIP1. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- HIV-1 reverse transcriptase inhibitors: current issues and future perspectives. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Specific targeting of hepatitis C virus NS3 RNA helicase. Discovery of the potent and selective competitive nucleotide-mimicking inhibitor QU663. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Novel 1-[2-(diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. A structure-activity relationship investigation. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- 8-oxoguanine incorporation into DNA repeats in vitro and mismatch recognition by MutSalpha. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Incorporation of non-nucleoside triphosphate analogues opposite to an abasic site by human DNA polymerases beta and lambda. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- 5-Alkyl-2-alkylamino-6-(2,6-difluorophenylalkyl)-3,4-dihydropyrimidin-4(3H)-ones, a new series of potent, broad-spectrum non-nucleoside reverse transcriptase inhibitors belonging to the DABO family. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Human proliferating cell nuclear antigen, poly(ADP-ribose) polymerase-1, and p21waf1/cip1. A dynamic exchange of partners. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Synthesis, properties, and pharmacokinetic studies of N2-phenylguanine derivatives as inhibitors of herpes simplex virus thymidine kinases. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Identification, partial purification and inhibition by guanine analogues of a novel enzymic activity which phosphorylates guanosine to GMP in the protozoan parasite Eimeria tenella (Articolo in rivista) (Prodotto della ricerca)
- New indolylarylsulfones as highly potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors (Articolo in rivista) (Prodotto della ricerca)
- Final Report IV National AIDS Program: Project 30D.72 (Rapporti progetti di ricerca) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1714)
- Studio delle farmaco-resistenze crociate della RT di HIV-1 a inibitori nucleosidici e non-nucleosidici e sviluppo di nuovi analoghi L-nucleosidici anti-HIV a bassa citotossicità (Rapporti progetti di ricerca) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1714)
- Resistance to Nevirapine of HIV-1 reverse transcriptase mutants: Loss of stabilizing interactions and thermodynamic or steric barriers are induced by different single amino acid substitutions (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Final Report FP6 EU Project Targeting Replication and Integration of HIV-TRIoH (Rapporti progetti di ricerca) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1714)
- Exploring the Role of 2-Chloro-6-fluoro Substitution in 2-Alkylthio-6-benzyl-5-alkylpyrimidin-4(3H)-ones: Effects in HIV-1-Infected Cells and in HIV-1 Reverse Transcriptase Enzymes (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Exploring the chemical space around the privileged pyrazolo[3,4-d] pyrimidine scaffold: Toward novel allosteric inhibitors of T315I-mutated Abl (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Indolylarylsulfones Carrying a Heterocyclic Tail as Very Potent and Broad Spectrum HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors (Articolo in rivista) (Prodotto della ricerca)
- The goods and bads of DNA polymerases ? and ? actions on CAG repeats and telomeric DNA sequences (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Human DNA polymerase l binds to the front side of PCNA through a conserved HhH-motif and its binding is regulated by p21 (Comunicazione a convegno) (Prodotto della ricerca)
- DNA polymerase l interacts with PCNA in normal and translesion DNA synthesis (Comunicazione a convegno) (Prodotto della ricerca)
- Auxiliary proteins PCNA, RP-A and 9-1-1 together with Fen-1 avoid functional redundance between human DNA polymerases beta and lambda in promoting genomic integrity (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Functional domains of human DNA polymerase l: a molecular anatomy approach (Comunicazione a convegno) (Prodotto della ricerca)
- Quality control of DNA: DNA polymerase lambda functions in DNA synthesis over damaged and depurinated DNA (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- PCNA, PARP-1 and p21: a dynamic exchange of partners. (Comunicazione a convegno) (Prodotto della ricerca)
- Mutations coferring interclass antiretroviral drug resistance and their impact on HIV-1 replicative capacity (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Repair DNA polymerases as anticancer drug targets (Abstract/Comunicazione in rivista) (Prodotto della ricerca)
- Photoreactive DNA probes as a tool for studying the translesion synthesis system in mammalian cell extracts (Articolo in rivista) (Prodotto della ricerca)
- Characterization of novel N,N-DABOs as effective tight binding non-nucleoside inhibitors of HIV-1 RT. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Novel HIV-1 NNRTIs with reduced loss of potency against common drug-resistant mutations. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Novel NNRTIs (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Second generation PBOs show enantioselective binding to the catalytic complex of HIV-1 RT wt and drug resistant mutants. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- through a conserved helix-hairpin-helix motif and its binding is regulated by p21. (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Hepatitis C virus NS3 ATP/ase/helicase: an ATP switch regulates the cooperativity among the different substrate binding sites. (Articolo in rivista) (Prodotto della ricerca)
- Identificazione di nuovi target e di nuove molecole antitumorali e antivirali (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- A new and efficient synthesis of substituted 6-(2-dialkylamono)ethyl pyrimidine and 4-N, N-dialkyl-6-vinyl-cytosine derivatives and evaluation of their anti-rubella activity. (Articolo in rivista) (Prodotto della ricerca)
- DNA polymerase theta purified from human cells is a high-fidelity enzyme. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Two birds with a stone: from single- to multi-target drugs in cancer therapy (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Una cura per l'AIDS: illusioni, certezze e nuove speranze (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Current state-of-the-art in preclinical and clinical development of novel non-nucleoside HIV-1 reverse transcriptase inhibitors (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- DNA polymerase lambda specifically bridges and extends DNA ends containing microhomoloy regions (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- DNA polymerase lambda specifically bridges and extends DNA ends containing microhomoloy regions (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Human DNA polymerases lambda and beta show different efficiencies of translesion DNA synthesis past abasic sites and alternative mechanisms for frameshift generation. (Articolo in rivista) (Prodotto della ricerca)
- De novo DNA synthesis by human DNA polymerase lambda, DNA polymerase mu and terminal deoxyribonucleotidyl transferase. (Articolo in rivista) (Prodotto della ricerca)
- Biochemical Approach of PCNA1 and PCNA2 proteins interaction with DNA pol lambda of Arabidopsis thaliana (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Biochemical Approach of PCNA1 and PCNA2 proteins interaction with DNA pol lambda of Arabidopsis thaliana (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Gln145Met/Leu changes in human immunodeficiency virus type 1 reverse transcriptase confer resistance to nucleoside and nonnucleoside analogs and impair virus replication. (Articolo in rivista) (Prodotto della ricerca)
- Parallel solution-phase synthesis of 4-dialkylamino-2-methylsulfonyl-6-vinylpyrimidines. (Articolo in rivista) (Prodotto della ricerca)
- Proliferating cell nuclear antigen (PCNA): a dancer with many partners (Articolo in rivista) (Prodotto della ricerca)
- Human DNA polymerase lambda diverged in evolution from DNA polymerase beta toward specific Mn(++) dependence: a kinetic and thermodynamic study (Articolo in rivista) (Prodotto della ricerca)
- AIDS: la verità negata (Monografia o trattato scientifico) (Prodotto della ricerca)
- Human Immunodeficiency Virus (HIV-1) Auxiliary Protein Vif and Cellular APOBEC Deaminases: Their Roles Unveiled? (Articolo in rivista) (Prodotto della ricerca)
- Indolyl aryl sulphones as HIV-1 non-nucleoside reverse transcriptase inhibitors: synthesis, biological evaluation and binding mode studies of new derivatives at indole-2-carboxamide. (Articolo in rivista) (Prodotto della ricerca)
- Synthesis and biological investigation of S-aryl-S-DABO derivatives as HIV-1 inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: Discovery, characterization, and crystal structure in complex with the target (Articolo in rivista) (Prodotto della ricerca)
- A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- Identification of Hck Inhibitors As Hits for the Development of Antileukemia and Anti-HIV Agents (Articolo in rivista) (Prodotto della ricerca)
- Q145M, a novel HIV-1 reverse transcriptase mutation conferring resistance to nucleoside and non-nucleoside reverse transcriptase inhibitors (Articolo in rivista) (Prodotto della ricerca)
- DNA polymerase delta-interacting protein 2 is a processivity factor for DNA polymerase lambda during 8-oxo-7,8-dihydroguanine bypass. (Articolo in rivista) (Prodotto della ricerca)
- Indolyl aryl sulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: role of two halogen atoms at the indole ring in developing new analogues with improved antiviral activity. (Articolo in rivista) (Prodotto della ricerca)
- Design, synthesis, and biological evaluation of pyrazolo[3,4-d]pyrimidines active in vivo on the Bcr-Abl T315I mutant (Articolo in rivista) (Prodotto della ricerca)
- Hepatitis C virus NS3 NTPase/helicase: different stereoselectivity in nucleoside triphosphate utilisation suggests that NTPase and helicase activities are coupled by a nucleotide-dependent rate limiting step. (Articolo in rivista) (Prodotto della ricerca)
- HIV-1 reverse transcriptase and integrase enzymes physically interact and inhibit each other. (Articolo in rivista) (Prodotto della ricerca)
- Discovery of novel benzimidazolones as potent non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains. (Articolo in rivista) (Prodotto della ricerca)
- Okazaki fragment processing: modulation of the strand displacement activity of DNA polymerase delta by the concerted action of replication protein A, proliferating cell nuclear antigen, and flap endonuclease-1. (Articolo in rivista) (Prodotto della ricerca)
- Specific structural determinants are responsible for the antioxidant activity and the cell cycle effects of resveratrol. (Articolo in rivista) (Prodotto della ricerca)
- Potentiation of inhibition of wild-type and mutant human immunodeficiency virus type 1 reverse transcriptases by combinations of nonnucleoside inhibitors and d- and L-(beta)-dideoxynucleoside triphosphate analogs. (Articolo in rivista) (Prodotto della ricerca)
- Dihydro-alkylthio-benzyl-oxopyrimidines as inhibitors of reverse transcriptase: synthesis and rationalization of the biological data on both wild-type enzyme and relevant clinical mutants. (Articolo in rivista) (Prodotto della ricerca)
- Microhomology-mediated DNA strand annealing and elongation by human DNA polymerases ? and ? on normal and repetitive DNA sequences (Articolo in rivista) (Prodotto della ricerca)
- Combinations against combinations: associations of anti-HIV 1 revese transcriptase drugs challenged by constellations of drug resistance mutations. (Articolo in rivista) (Prodotto della ricerca)
- New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors (Articolo in rivista) (Prodotto della ricerca)
- New targets and new drugs: from in silico planning to in vivo testing (Articolo in rivista) (Prodotto della ricerca)
- Vif is an auxiliary factor of the HIV-1 reverse transcriptase and facilitates abasic site bypass. (Articolo in rivista) (Prodotto della ricerca)
- Effects of drug resistance mutations L100I and V106A on the binding of pyrrolobenzoxazepinone nonnucleoside inhibitors to the human immunodeficiency virus type 1 reverse transcriptase catalytic complex. (Articolo in rivista) (Prodotto della ricerca)
- Human DEAD-box ATPase DDX3 shows a relaxed nucleoside substrate specificity. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Diketo hexenoic acid derivatives are novel selective non-nucleoside inhibitors of mammalian terminal deoxynucleotidyl transferases, with potent cytotoxic effect against leukemic cells. (Articolo in rivista) (Prodotto della ricerca)
- Drug resistance mutations in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase differentially affect the phosphorolysis-dependent primer unblocking activity in the presence of stavudine and zidovudine and its inhib (Articolo in rivista) (Prodotto della ricerca)
- Eukaryotic DNA polymerases (Articolo in rivista) (Prodotto della ricerca)
- AKAP149 binds to HIV-1 reverse transcriptase and is involved in the reverse transcription. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Antivirals at the mirror: the lack of stereospecificity of some viral and human enzymes offers novel opportunities in antiviral drug development (Articolo in rivista) (Prodotto della ricerca)
- Interazione diretta tra PARP-1, PCNA e p21: un possible ruolo nella regolazione di PCNA dalla replicazione alla riparazione del DNA? (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Nevirapine resistance mutation at codon 181 of the HIV-1 reverse transcriptase confers stavudine resistance by increasing nucleotide substrate discrimination and phosphorolytic activity (Articolo in rivista) (Prodotto della ricerca)
- DNA replication: a complex matter (Articolo in rivista) (Prodotto della ricerca)
- Selective interactions of human kin17 and RPA proteins with chromatin and the nuclear matrix in a DNA damage- and cell cycle-regulated manner. (Articolo in rivista) (Prodotto della ricerca)
- Human DNA polymerase lambda possesses terminal deoxyribonucleotidyl transferase activity and can elongate RNA primers: implications for novel functions (Articolo in rivista) (Prodotto della ricerca)
- Nevirapine-selected mutations Y181I/C of HIV-1 reverse transcriptase confer cross-resistance to stavudine (Articolo in rivista) (Prodotto della ricerca)
- Replication protein A and proliferating cell nuclear antigen coordinate DNA polymerase selection in 8-oxo-guanine repair. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The human stress-activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins. (Articolo in rivista) (Prodotto della ricerca)
- Inhibition of mammalian DNA polymerases by resveratrol: mechanism and structural determinants. (Articolo in rivista) (Prodotto della ricerca)
- Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Computational strategies in discovering novel non-nucleoside inhibitors of HIV-1 RT. (Articolo in rivista) (Prodotto della ricerca)
- Indolyl-pyrrolone as a new scaffold for Pim1 inhibitors. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The block of DNA polymerase delta strand displacement activity by an abasic site can be rescued by the concerted action of DNA polymerase beta and flap endonuclease 1. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Parallel solution-phase and microwave-assisted synthesis of new S-DABO derivatives endowed with subnanomolar anti-HIV-1 activity. (Articolo in rivista) (Prodotto della ricerca)
- Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity. (Articolo in rivista) (Prodotto della ricerca)
- Towards novel S-DABOC inhibitors: Synthesis, biological investigation, and molecular modeling studies. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Human replication protein A can suppress the intrinsic in vitro mutator phenotype of human DNA polymerase lambda. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- DNA polymerases and mutagenesis in human cancers. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Identification of a Novel Pyrazolo[3,4-d]pyrimidine Able To Inhibit Cell Proliferation of a Human Osteogenic Sarcoma in Vitro and in a Xenograft Model in Mice. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Discovery of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase Competing with the Nucleotide Substrate. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Replication of 2-hydroxyadenine-containing DNA and recognition by human MutSalpha. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Novel 1,3-dihydro-benzimidazol-2-ones and their analogues as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- Error-free bypass of 2-hydroxyadenine by human DNA polymerase lambda with Proliferating Cell Nuclear Antigen and Replication Protein A in different sequence contexts. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Expanding the repertoire of DNA polymerase substrates: template-instructed incorporation of non-nucleoside triphosphate analogues by DNA polymerases beta and lambda. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Pyrrolobenzoxazepinone derivatives as non-nucleoside HIV-1 RT inhibitors: Further structure-activity relationship studies and identification of more potent broad-spectrum HIV-1 RT inhibitors with antiviral activity (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Replication protein a as a \"fidelity clamp\" for DNA polymerase alpha (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Mutant DNA polymerase delta from thermosensitive Schizosaccharomyces pombe strains display reduced stimulation by proliferating cell nuclear antigen (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis and biological evaluation of novel quinoxalinylethylpyridylthioureas as potent antiviral agents (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- DNA polymerase switching: I. Replication factor C displaces DNA polymerase alpha prior to PCNA loading (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase. (Articolo in rivista) (Prodotto della ricerca)
- Indolylarylsulfones as HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: New Cyclic Substituents at Indole-2-carboxamide. (Articolo in rivista) (Prodotto della ricerca)
- 8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Modulation of the (in)fidelity of DNA polymerase lamda by PCNA and RP-A (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Effetti di differenti mutazioni nella RT di HIV-1 sulla fitness virale e sulla resistenza multipla a inibitori nucleosidici e non-nucleosidici (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- DNA polymerase lamda: mechanism of frameshift generation and regulation of its terminal-transferase and polymerase activities by PCNA and RP-A (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- The balance between the rates of incorporation and pyrophosphorolytic removal influences the HIV-1 reverse transcriptase bypass of an abasic site with deoxy-, dideoxy-, and ribonucleotides. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Investigation of novel lipid-functionalized PNA monomers as potential HIV-1 non-nucleoside reverse transcriptase and/or integrase inhibitors. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- APOBEC deaminases as cellular antiviral factors: a novel natural host defense mechanism. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Slow-, Tight-Binding HIV-1 Reverse Transcriptase Non-Nucleoside Inhibitors Highly Active against Drug-Resistant Mutants. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Mechanism of interaction of novel indolylarylsulfone derivatives with K103N and Y181I mutant HIV-1 reverse transcriptase in complex with its substrates. (Articolo in rivista) (Prodotto della ricerca)
- Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- A multidisciplinary approach for the identification of novel HIV-1 non-nucleoside reverse transcriptase inhibitors: S-DABOCs and DAVPs. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Novel N1-substituted 1,3-dihydro-2H-benzimidazol-2-ones as potent non-nucleoside reverse transcriptase inhibitors. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Toward the discovery of novel anti-HIV drugs. Second-generation inhibitors of the cellular ATPase DDX3 with improved anti-HIV activity: synthesis, structure-activity relationship analysis, cytotoxicity studies, and target validation. (Articolo in rivista) (Prodotto della ricerca)
- The PDZ-Ligand and Src-Homology Type 3 Domains of Epidemic Avian Influenza Virus NS1 Protein Modulate Human Src Kinase Activity during Viral Infection. (Articolo in rivista) (Prodotto della ricerca)
- N-(thiazol-2-yl)-2-thiophene carboxamide derivatives as Abl inhibitors identified by a pharmacophore-based database screening of commercially available compounds. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- 5-Alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones, a series of anti-HIV-1 agents of the dihydro-alkoxy-benzyl-oxopyrimidine family with peculiar structure-activity relationship profile. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Substrate-Induced Stable Enzyme-Inhibitor Complex Formation Allows Tight Binding of Novel 2-Aminopyrimidin-4(3H)-ones to Drug-Resistant HIV-1 Reverse Transcriptase Mutants. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Pharmacophore modeling and molecular docking led to the discovery of inhibitors of human immunodeficiency virus-1 replication targeting the human cellular aspartic acid-glutamic acid-alanine-aspartic acid box polypeptide 3. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Non-nucleoside HIV-1 reverse transcriptase inhibitors di-halo-indolyl aryl sulfones achieve tight binding to drug-resistant mutants by targeting the enzyme-substrate complex. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Discovery of chiral cyclopropyl dihydro-alkylthio-benzyl-oxopyrimidine (S-DABO) derivatives as potent HIV-1 reverse transcriptase inhibitors with high activity against clinically relevant mutants. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Probing interactions between HIV-1 reverse transcriptase and its DNA substrate with backbone-modified nucleotides (Articolo in rivista) (Prodotto della ricerca)
- Molecular basis for the enantioselectivity of HIV-1 reverse transcriptase: role of the 3 '-hydroxyl group of the L-(beta)-ribose in chiral discrimination between D- and L-enantiomers of deoxy- and dideoxy-nucleoside triphosphate analogs (Articolo in rivista) (Prodotto della ricerca)
- Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Structural determinants of HIV-1 reverse transcriptase stereoselectivity towards (beta)-L-deoxy- and dideoxy pyrimidine nucleoside triphosphates: Molecular basis for the combination of L-dideoxynucleoside analogs with nonnucleoside inhibitors in anti HIV chemotherapy. (Articolo in rivista) (Prodotto della ricerca)
- Dual mode of interaction of DNA polymerase epsilon with proliferating cell nuclear antigen in primer binding and DNA synthesis (Articolo in rivista) (Prodotto della ricerca)
- The solution structure of functionally active human proliferating cell nuclear antigen determined by small-angle neutron scattering (Articolo in rivista) (Prodotto della ricerca)
- Cell cycle-dependent dynamic association of cyclin/Cdk complexes with human DNA replication proteins. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Mutational analysis of the HIV-1 auxiliary protein Vif identifies independent domains important for the physical and functional interaction with HIV-1 reverse transcriptase. (Articolo in rivista) (Prodotto della ricerca)
- DNA polymerase lambda: mechanism of frameshift generation and regulation of its terminal-transferase and polymerase activities by PCNA an (Comunicazione a convegno) (Prodotto della ricerca)
- Nevirapine Resistance Mutation at Codon 181 of the HIV-1 Reverse Transcriptase Confers Stavudine Resistance by Increasing Nucleotide Substrate Discrimination and Phosphorolytic Activity. (Comunicazione a convegno) (Prodotto della ricerca)
- Mutagenesis of human DNA polymerase lambda: essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Human DNA polymerase lambda binds to the front side of PCNA through a conserved HhH-motif and its binding is regulated by p21 (Comunicazione a convegno) (Prodotto della ricerca)
- Detection of a new HIV-1 reverse transcriptase mutation (Q145M) conferring resistance to nucleoside and non-nucleoside inhibitors in a patient failing highly active antiretroviral therapy (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- High potency of indolyl aryl sulfone nonnucleoside inhibitors towards drug-resistant human immunodeficiency virus type 1 reverse transcriptase mutants is due to selective targeting of different mechanistic forms of the enzyme. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data. (Articolo in rivista) (Prodotto della ricerca)
- Human terminal deoxynucleotidyl transferases as novel targets for anticancer chemotherapy. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Design, molecular modeling, synthesis, and anti-HIV-1 activity of new indolyl aryl sulfones. Novel derivatives of the indole-2-carboxamide. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Pyrazolo[3,4-d]pyrimidine prodrugs: Strategic optimization of the aqueous solubility of dual Src/Abl inhibitors (Articolo in rivista) (Prodotto della ricerca)
- Slow binding-tight binding interaction between benzimidazol-2-one inhibitors and HIV-1 reverse transcriptase containing the lysine 103 to asparagine mutation. (Articolo in rivista) (Prodotto della ricerca)
- Genetic divergence of influenza A NS1 gene in pandemic 2009 H1N1 isolates with respect to H1N1 and H3N2 isolates from previous seasonal epidemics. (Articolo in rivista) (Prodotto della ricerca)
- Design and synthesis of thiadiazoles and thiazoles targeting the Bcr-Abl T315I mutant: from docking false positives to ATP-noncompetitive inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- Synthesis and Biological Properties of Novel 2-Aminopyrimidin-4(3H)-ones Highly Potent against HIV-1 Mutant Strains. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- 2,3-Dihydro-1,2-Diphenyl-substituted 4H-Pyridinone Derivatives as New Anti Flaviviridae Inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- The stereoselective targeting of a specific enzyme-substrate complex is the molecular mechanism for the synergic inhibition of HIV-1 reverse transcriptase by (R)-(-)-PPO464: a novel generation of nonnucleoside inhibitors. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- DNA polymerases and cancer (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Inhibition of Bcr-Abl Phosphorylation and Induction of Apoptosis by Pyrazolo[3,4-d]pyrimidines in Human Leukemia Cells. (Articolo in rivista) (Prodotto della ricerca)
- Human base excision repair complex is physically associated to DNA replication and cell cycle regulatory proteins. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Arylthiopyrrole (AThP) Derivatives as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors: Synthesis, Structure-Activity Relationships, and Docking Studies (Part 2). (Articolo in rivista) (Prodotto della ricerca)
- NNRTI-selected mutations at codon 190 of human immunodeficiency virus type 1 reverse transcriptase decrease susceptibility to stavudine and zidovudine. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Structure-based pharmacophore identification of new chemical scaffolds as non-nucleoside reverse transcriptase inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- Cytotoxicity of alpha-dicarbonyl compounds submitted to in vitro simulated digestion process (Articolo in rivista) (Prodotto della ricerca)
- Diarylpyrimidine-Dihydrobenzyloxopyrimidine Hybrids: New, Wide-Spectrum Anti-HIV-1 Agents Active at (Sub)-Nanomolar Level. (Articolo in rivista) (Prodotto della ricerca)
- HCV-targeted antivirals: Current status and future challenges (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- 3D QSAR Models Built on Structure-Based Alignments of Abl Tyrosine Kinase Inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- Ruolo funzionale della proteina Vif di HIV-1 nel processo di retrotrascrizione del genoma virale (Rapporti progetti di ricerca) (Prodotto della ricerca)
- What makes Y family Pols potential candidates for molecular targeted therapies and novel biotechnological applications (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Inhibition of Subgenomic Hepatitis C Virus RNA Replication by Acridone Derivatives: Identification of an NS3 Helicase Inhibitor. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- A new proofreading mechanism for lesion bypass by DNA polymerase-lambda (Articolo in rivista) (Prodotto della ricerca)
- The resveratrol analogue 4,4'-dihydroxy-trans-stilbene inhibits cell proliferation with higher efficiency but different mechanism from resveratrol. (Articolo in rivista) (Prodotto della ricerca)
- Design, synthesis, and structure-activity relationships of 1,3-dihydrobenzimidazol-2-one analogues as anti-HIV agents. (Articolo in rivista) (Prodotto della ricerca)
- Pyridobenzothiazole derivatives as new chemotype targeting the HCV NS5B polymerase. (Articolo in rivista) (Prodotto della ricerca)
- Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- DNA polymerases beta and lambda bypass thymine glycol in gapped DNA structures. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Dual Src and Abl inhibitors target wild type Abl and the AblT315I Imatinib-resistant mutant with different mechanisms. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Molecular Characterization of c-Abl/c-Src Kinase Inhibitors Targeted against Murine Tumour Progenitor Cells that Express Stem Cell Markers. (Articolo in rivista) (Prodotto della ricerca)
- Oxidative DNA Damage Bypass in Arabidopsis thaliana Requires DNA Polymerase {lambda} and Proliferating Cell Nuclear Antigen 2. (Articolo in rivista) (Prodotto della ricerca)
- N2-Benzyloxycarbonylguan-9-yl Acetic Acid Derivatives as HIV-1 Reverse Transcriptase Non-Nucleoside Inhibitors with Decreased Loss of Potency Against Common Drug-Resistance Mutations. (Articolo in rivista) (Prodotto della ricerca)
- Design, Synthesis, Biological Activity, and ADME Properties of Pyrazolo[3,4-d]pyrimidines Active in Hypoxic Human Leukemia Cells: A Lead Optimization Study. (Articolo in rivista) (Prodotto della ricerca)
- Overcoming the Drug Resistance Problem with Second-Generation Tyrosine Kinase Inhibitors: From Enzymology to Structural Models. (Articolo in rivista) (Prodotto della ricerca)
- Targeting the Human DEAD-Box Polypeptide 3 (DDX3) RNA Helicase as a Novel Strategy to Inhibit Viral Replication. (Articolo in rivista) (Prodotto della ricerca)
- Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants. (Articolo in rivista) (Prodotto della ricerca)
- DNA elongation by the human DNA polymerase ? polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- A Motif Unique to the Human Dead-Box Protein DDX3 Is Important for Nucleic Acid Binding, ATP Hydrolysis, RNA/DNA Unwinding and HIV-1 Replication. (Articolo in rivista) (Prodotto della ricerca)
- N-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a Scaffold for the Synthesis of Inhibitors of Bcr-Abl. (Articolo in rivista) (Prodotto della ricerca)
- DNA replication and repair bypass machines. (Articolo in rivista) (Prodotto della ricerca)
- Exploiting the nucleotide substrate specificity of repair DNA polymerases to develop novel anticancer agents. (Articolo in rivista) (Prodotto della ricerca)
- The 2009 Influenza Pandemic: Promising Lessons for Antiviral Therapy For Future Outbreaks. (Articolo in rivista) (Prodotto della ricerca)
- Synthesis, biological activity, and ADME properties of novel S-DABOs/N-DABOs as HIV reverse transcriptase inhibitors (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The power of enzyme kinetics in the drug development process (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- New in silico and conventional in vitro approaches to advance HIV drug discovery and design (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Occhio ai virus (Monografia o trattato scientifico) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1401)
- Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: towards the next generation HIV-1 inhibitors (Articolo in rivista) (Prodotto della ricerca)
- 2-(Alkyl/aryl)amino-6-benzylpyrimidin-4(3H)-ones as inhibitors of wild-type and mutant HIV-1: enantioselectivity studies (Articolo in rivista) (Prodotto della ricerca)
- Tyrosine kinases as essential cellular cofactors and potential therapeutic targets for human immunodeficiency virus infection (Articolo in rivista) (Prodotto della ricerca)
- Human DNA Polymerase beta, but Not lambda, Can Bypass a 2-Deoxyribonolactone Lesion Together with Proliferating Cell Nuclear Antigen (Articolo in rivista) (Prodotto della ricerca)
- Combining X-ray crystallography and molecular modeling toward the optimization of pyrazolo[3,4-d ]pyrimidines as potent c-Src inhibitors active in vivo against neuroblastoma (Articolo in rivista) (Prodotto della ricerca)
- NEW 4-SUBSTITUTED DERIVATIVES OF PYRAZOLO[3,4-d]PYRIMIDINE AND PYRROLO[2,3-d]PYRIMIDINE AND USES THEREOF (Brevetto) (Prodotto della ricerca)
- Design, synthesis, biological evaluation, and molecular modeling studies of TIBO-like cyclic sulfones as non-nucleoside HIV-1 reverse transcriptase inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- Reconstitution of the base excision repair pathway for 7,8-dihydro-8-oxoguanine with purified human proteins. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- CRYSTAL STRUCTURE OF THE HIV-1 REVERSE TRANSCRIPTASE BOUND TO A NUCLEOTIDE-COMPETITIVE REVERSE TRANSCRIPTASE INHIBITOR AND THE USE THEREOF (Brevetto) (Prodotto della ricerca)
- COMPOUNDS WITH DDX3 INHIBITORY ACTIVITY AND USES THEREOF (Brevetto) (Prodotto della ricerca)
- Final Report FP5 EU Project DNA replication and Biotechnology (Rapporti progetti di ricerca) (Prodotto della ricerca)
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- Combinations against combinations: associations of anti-HIV 1 revese transcriptase drugs challenged by constellations of drug resistance mutations. (Articolo in rivista) (Prodotto della ricerca)
- Vif is an auxiliary factor of the HIV-1 reverse transcriptase and facilitates abasic site bypass. (Articolo in rivista) (Prodotto della ricerca)
- Effects of drug resistance mutations L100I and V106A on the binding of pyrrolobenzoxazepinone nonnucleoside inhibitors to the human immunodeficiency virus type 1 reverse transcriptase catalytic complex. (Articolo in rivista) (Prodotto della ricerca)
- Diketo hexenoic acid derivatives are novel selective non-nucleoside inhibitors of mammalian terminal deoxynucleotidyl transferases, with potent cytotoxic effect against leukemic cells. (Articolo in rivista) (Prodotto della ricerca)
- Drug resistance mutations in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase differentially affect the phosphorolysis-dependent primer unblocking activity in the presence of stavudine and zidovudine and its inhib (Articolo in rivista) (Prodotto della ricerca)
- Eukaryotic DNA polymerases (Articolo in rivista) (Prodotto della ricerca)
- Antivirals at the mirror: the lack of stereospecificity of some viral and human enzymes offers novel opportunities in antiviral drug development (Articolo in rivista) (Prodotto della ricerca)
- Nevirapine resistance mutation at codon 181 of the HIV-1 reverse transcriptase confers stavudine resistance by increasing nucleotide substrate discrimination and phosphorolytic activity (Articolo in rivista) (Prodotto della ricerca)
- Human DNA polymerase lambda possesses terminal deoxyribonucleotidyl transferase activity and can elongate RNA primers: implications for novel functions (Articolo in rivista) (Prodotto della ricerca)
- Nevirapine-selected mutations Y181I/C of HIV-1 reverse transcriptase confer cross-resistance to stavudine (Articolo in rivista) (Prodotto della ricerca)
- DNA replication: a complex matter (Articolo in rivista) (Prodotto della ricerca)
- Selective interactions of human kin17 and RPA proteins with chromatin and the nuclear matrix in a DNA damage- and cell cycle-regulated manner. (Articolo in rivista) (Prodotto della ricerca)
- Computational strategies in discovering novel non-nucleoside inhibitors of HIV-1 RT. (Articolo in rivista) (Prodotto della ricerca)
- The human stress-activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins. (Articolo in rivista) (Prodotto della ricerca)
- Inhibition of mammalian DNA polymerases by resveratrol: mechanism and structural determinants. (Articolo in rivista) (Prodotto della ricerca)
- Parallel solution-phase and microwave-assisted synthesis of new S-DABO derivatives endowed with subnanomolar anti-HIV-1 activity. (Articolo in rivista) (Prodotto della ricerca)
- Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity. (Articolo in rivista) (Prodotto della ricerca)
- Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Human replication protein A can suppress the intrinsic in vitro mutator phenotype of human DNA polymerase lambda. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Identification of a Novel Pyrazolo[3,4-d]pyrimidine Able To Inhibit Cell Proliferation of a Human Osteogenic Sarcoma in Vitro and in a Xenograft Model in Mice. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Discovery of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase Competing with the Nucleotide Substrate. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Replication of 2-hydroxyadenine-containing DNA and recognition by human MutSalpha. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Expanding the repertoire of DNA polymerase substrates: template-instructed incorporation of non-nucleoside triphosphate analogues by DNA polymerases beta and lambda. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Error-free bypass of 2-hydroxyadenine by human DNA polymerase lambda with Proliferating Cell Nuclear Antigen and Replication Protein A in different sequence contexts. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Replication protein a as a \"fidelity clamp\" for DNA polymerase alpha (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- 8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The balance between the rates of incorporation and pyrophosphorolytic removal influences the HIV-1 reverse transcriptase bypass of an abasic site with deoxy-, dideoxy-, and ribonucleotides. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Investigation of novel lipid-functionalized PNA monomers as potential HIV-1 non-nucleoside reverse transcriptase and/or integrase inhibitors. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- A multidisciplinary approach for the identification of novel HIV-1 non-nucleoside reverse transcriptase inhibitors: S-DABOCs and DAVPs. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- 5-Alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones, a series of anti-HIV-1 agents of the dihydro-alkoxy-benzyl-oxopyrimidine family with peculiar structure-activity relationship profile. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Novel N1-substituted 1,3-dihydro-2H-benzimidazol-2-ones as potent non-nucleoside reverse transcriptase inhibitors. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- N-(thiazol-2-yl)-2-thiophene carboxamide derivatives as Abl inhibitors identified by a pharmacophore-based database screening of commercially available compounds. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Substrate-Induced Stable Enzyme-Inhibitor Complex Formation Allows Tight Binding of Novel 2-Aminopyrimidin-4(3H)-ones to Drug-Resistant HIV-1 Reverse Transcriptase Mutants. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Pharmacophore modeling and molecular docking led to the discovery of inhibitors of human immunodeficiency virus-1 replication targeting the human cellular aspartic acid-glutamic acid-alanine-aspartic acid box polypeptide 3. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Discovery of chiral cyclopropyl dihydro-alkylthio-benzyl-oxopyrimidine (S-DABO) derivatives as potent HIV-1 reverse transcriptase inhibitors with high activity against clinically relevant mutants. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Non-nucleoside HIV-1 reverse transcriptase inhibitors di-halo-indolyl aryl sulfones achieve tight binding to drug-resistant mutants by targeting the enzyme-substrate complex. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Mutational analysis of the HIV-1 auxiliary protein Vif identifies independent domains important for the physical and functional interaction with HIV-1 reverse transcriptase. (Articolo in rivista) (Prodotto della ricerca)
- Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data. (Articolo in rivista) (Prodotto della ricerca)
- Slow binding-tight binding interaction between benzimidazol-2-one inhibitors and HIV-1 reverse transcriptase containing the lysine 103 to asparagine mutation. (Articolo in rivista) (Prodotto della ricerca)
- Genetic divergence of influenza A NS1 gene in pandemic 2009 H1N1 isolates with respect to H1N1 and H3N2 isolates from previous seasonal epidemics. (Articolo in rivista) (Prodotto della ricerca)
- Design and synthesis of thiadiazoles and thiazoles targeting the Bcr-Abl T315I mutant: from docking false positives to ATP-noncompetitive inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- 2,3-Dihydro-1,2-Diphenyl-substituted 4H-Pyridinone Derivatives as New Anti Flaviviridae Inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- Inhibition of Bcr-Abl Phosphorylation and Induction of Apoptosis by Pyrazolo[3,4-d]pyrimidines in Human Leukemia Cells. (Articolo in rivista) (Prodotto della ricerca)
- Arylthiopyrrole (AThP) Derivatives as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors: Synthesis, Structure-Activity Relationships, and Docking Studies (Part 2). (Articolo in rivista) (Prodotto della ricerca)
- Structure-based pharmacophore identification of new chemical scaffolds as non-nucleoside reverse transcriptase inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- Diarylpyrimidine-Dihydrobenzyloxopyrimidine Hybrids: New, Wide-Spectrum Anti-HIV-1 Agents Active at (Sub)-Nanomolar Level. (Articolo in rivista) (Prodotto della ricerca)
- Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- A new proofreading mechanism for lesion bypass by DNA polymerase-lambda (Articolo in rivista) (Prodotto della ricerca)
- Pyridobenzothiazole derivatives as new chemotype targeting the HCV NS5B polymerase. (Articolo in rivista) (Prodotto della ricerca)
- DNA polymerase lambda from calf thymus preferentially replicates damaged DNA. (Articolo in rivista) (Prodotto della ricerca)
- Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis. (Articolo in rivista) (Prodotto della ricerca)
- The RNA helicase, nucleotide 5'-triphosphatase, and RNA 5'-triphosphatase activities of Dengue virus protein NS3 are Mg2+-dependent and require a functional Walker B motif in the helicase catalytic core. (Articolo in rivista) (Prodotto della ricerca)
- The human DNA polymerase lambda interacts with PCNA through a domain important for DNA primer binding and the interaction is inhibited by p21/WAF1/CIP1. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- HIV-1 reverse transcriptase inhibitors: current issues and future perspectives. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- 8-oxoguanine incorporation into DNA repeats in vitro and mismatch recognition by MutSalpha. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Incorporation of non-nucleoside triphosphate analogues opposite to an abasic site by human DNA polymerases beta and lambda. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Specific targeting of hepatitis C virus NS3 RNA helicase. Discovery of the potent and selective competitive nucleotide-mimicking inhibitor QU663. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Novel 1-[2-(diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. A structure-activity relationship investigation. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- 5-Alkyl-2-alkylamino-6-(2,6-difluorophenylalkyl)-3,4-dihydropyrimidin-4(3H)-ones, a new series of potent, broad-spectrum non-nucleoside reverse transcriptase inhibitors belonging to the DABO family. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Human proliferating cell nuclear antigen, poly(ADP-ribose) polymerase-1, and p21waf1/cip1. A dynamic exchange of partners. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Cell cycle-dependent dynamic association of cyclin/Cdk complexes with human DNA replication proteins. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Detection of a new HIV-1 reverse transcriptase mutation (Q145M) conferring resistance to nucleoside and non-nucleoside inhibitors in a patient failing highly active antiretroviral therapy (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Mutagenesis of human DNA polymerase lambda: essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- High potency of indolyl aryl sulfone nonnucleoside inhibitors towards drug-resistant human immunodeficiency virus type 1 reverse transcriptase mutants is due to selective targeting of different mechanistic forms of the enzyme. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Human terminal deoxynucleotidyl transferases as novel targets for anticancer chemotherapy. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Design, molecular modeling, synthesis, and anti-HIV-1 activity of new indolyl aryl sulfones. Novel derivatives of the indole-2-carboxamide. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Synthesis and Biological Properties of Novel 2-Aminopyrimidin-4(3H)-ones Highly Potent against HIV-1 Mutant Strains. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The stereoselective targeting of a specific enzyme-substrate complex is the molecular mechanism for the synergic inhibition of HIV-1 reverse transcriptase by (R)-(-)-PPO464: a novel generation of nonnucleoside inhibitors. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- NNRTI-selected mutations at codon 190 of human immunodeficiency virus type 1 reverse transcriptase decrease susceptibility to stavudine and zidovudine. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Human base excision repair complex is physically associated to DNA replication and cell cycle regulatory proteins. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- 3D QSAR Models Built on Structure-Based Alignments of Abl Tyrosine Kinase Inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- Inhibition of Subgenomic Hepatitis C Virus RNA Replication by Acridone Derivatives: Identification of an NS3 Helicase Inhibitor. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Design, synthesis, and structure-activity relationships of 1,3-dihydrobenzimidazol-2-one analogues as anti-HIV agents. (Articolo in rivista) (Prodotto della ricerca)
- The resveratrol analogue 4,4'-dihydroxy-trans-stilbene inhibits cell proliferation with higher efficiency but different mechanism from resveratrol. (Articolo in rivista) (Prodotto della ricerca)
- Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- DNA polymerases beta and lambda bypass thymine glycol in gapped DNA structures. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Dual Src and Abl inhibitors target wild type Abl and the AblT315I Imatinib-resistant mutant with different mechanisms. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- N2-Benzyloxycarbonylguan-9-yl Acetic Acid Derivatives as HIV-1 Reverse Transcriptase Non-Nucleoside Inhibitors with Decreased Loss of Potency Against Common Drug-Resistance Mutations. (Articolo in rivista) (Prodotto della ricerca)
- Molecular Characterization of c-Abl/c-Src Kinase Inhibitors Targeted against Murine Tumour Progenitor Cells that Express Stem Cell Markers. (Articolo in rivista) (Prodotto della ricerca)
- Oxidative DNA Damage Bypass in Arabidopsis thaliana Requires DNA Polymerase {lambda} and Proliferating Cell Nuclear Antigen 2. (Articolo in rivista) (Prodotto della ricerca)
- Design, Synthesis, Biological Activity, and ADME Properties of Pyrazolo[3,4-d]pyrimidines Active in Hypoxic Human Leukemia Cells: A Lead Optimization Study. (Articolo in rivista) (Prodotto della ricerca)
- Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants. (Articolo in rivista) (Prodotto della ricerca)
- Overcoming the Drug Resistance Problem with Second-Generation Tyrosine Kinase Inhibitors: From Enzymology to Structural Models. (Articolo in rivista) (Prodotto della ricerca)
- Targeting the Human DEAD-Box Polypeptide 3 (DDX3) RNA Helicase as a Novel Strategy to Inhibit Viral Replication. (Articolo in rivista) (Prodotto della ricerca)
- A Motif Unique to the Human Dead-Box Protein DDX3 Is Important for Nucleic Acid Binding, ATP Hydrolysis, RNA/DNA Unwinding and HIV-1 Replication. (Articolo in rivista) (Prodotto della ricerca)
- DNA replication and repair bypass machines. (Articolo in rivista) (Prodotto della ricerca)
- Exploiting the nucleotide substrate specificity of repair DNA polymerases to develop novel anticancer agents. (Articolo in rivista) (Prodotto della ricerca)
- N-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a Scaffold for the Synthesis of Inhibitors of Bcr-Abl. (Articolo in rivista) (Prodotto della ricerca)
- The 2009 Influenza Pandemic: Promising Lessons for Antiviral Therapy For Future Outbreaks. (Articolo in rivista) (Prodotto della ricerca)
- DNA polymerase theta purified from human cells is a high-fidelity enzyme. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Hepatitis C virus NS3 ATP/ase/helicase: an ATP switch regulates the cooperativity among the different substrate binding sites. (Articolo in rivista) (Prodotto della ricerca)
- A new and efficient synthesis of substituted 6-(2-dialkylamono)ethyl pyrimidine and 4-N, N-dialkyl-6-vinyl-cytosine derivatives and evaluation of their anti-rubella activity. (Articolo in rivista) (Prodotto della ricerca)
- Gln145Met/Leu changes in human immunodeficiency virus type 1 reverse transcriptase confer resistance to nucleoside and nonnucleoside analogs and impair virus replication. (Articolo in rivista) (Prodotto della ricerca)
- Human DNA polymerases lambda and beta show different efficiencies of translesion DNA synthesis past abasic sites and alternative mechanisms for frameshift generation. (Articolo in rivista) (Prodotto della ricerca)
- De novo DNA synthesis by human DNA polymerase lambda, DNA polymerase mu and terminal deoxyribonucleotidyl transferase. (Articolo in rivista) (Prodotto della ricerca)
- Parallel solution-phase synthesis of 4-dialkylamino-2-methylsulfonyl-6-vinylpyrimidines. (Articolo in rivista) (Prodotto della ricerca)
- Proliferating cell nuclear antigen (PCNA): a dancer with many partners (Articolo in rivista) (Prodotto della ricerca)
- Human DNA polymerase lambda diverged in evolution from DNA polymerase beta toward specific Mn(++) dependence: a kinetic and thermodynamic study (Articolo in rivista) (Prodotto della ricerca)
- Indolyl aryl sulphones as HIV-1 non-nucleoside reverse transcriptase inhibitors: synthesis, biological evaluation and binding mode studies of new derivatives at indole-2-carboxamide. (Articolo in rivista) (Prodotto della ricerca)
- A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- Synthesis and biological investigation of S-aryl-S-DABO derivatives as HIV-1 inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- Indolyl aryl sulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: role of two halogen atoms at the indole ring in developing new analogues with improved antiviral activity. (Articolo in rivista) (Prodotto della ricerca)
- Discovery of novel benzimidazolones as potent non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains. (Articolo in rivista) (Prodotto della ricerca)
- Okazaki fragment processing: modulation of the strand displacement activity of DNA polymerase delta by the concerted action of replication protein A, proliferating cell nuclear antigen, and flap endonuclease-1. (Articolo in rivista) (Prodotto della ricerca)
- Hepatitis C virus NS3 NTPase/helicase: different stereoselectivity in nucleoside triphosphate utilisation suggests that NTPase and helicase activities are coupled by a nucleotide-dependent rate limiting step. (Articolo in rivista) (Prodotto della ricerca)
- HIV-1 reverse transcriptase and integrase enzymes physically interact and inhibit each other. (Articolo in rivista) (Prodotto della ricerca)
- Specific structural determinants are responsible for the antioxidant activity and the cell cycle effects of resveratrol. (Articolo in rivista) (Prodotto della ricerca)
- Potentiation of inhibition of wild-type and mutant human immunodeficiency virus type 1 reverse transcriptases by combinations of nonnucleoside inhibitors and d- and L-(beta)-dideoxynucleoside triphosphate analogs. (Articolo in rivista) (Prodotto della ricerca)
- Dihydro-alkylthio-benzyl-oxopyrimidines as inhibitors of reverse transcriptase: synthesis and rationalization of the biological data on both wild-type enzyme and relevant clinical mutants. (Articolo in rivista) (Prodotto della ricerca)
- Human DEAD-box ATPase DDX3 shows a relaxed nucleoside substrate specificity. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- AKAP149 binds to HIV-1 reverse transcriptase and is involved in the reverse transcription. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Replication protein A and proliferating cell nuclear antigen coordinate DNA polymerase selection in 8-oxo-guanine repair. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Indolyl-pyrrolone as a new scaffold for Pim1 inhibitors. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The block of DNA polymerase delta strand displacement activity by an abasic site can be rescued by the concerted action of DNA polymerase beta and flap endonuclease 1. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Towards novel S-DABOC inhibitors: Synthesis, biological investigation, and molecular modeling studies. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- DNA polymerases and mutagenesis in human cancers. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Novel 1,3-dihydro-benzimidazol-2-ones and their analogues as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- Indolylarylsulfones as HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: New Cyclic Substituents at Indole-2-carboxamide. (Articolo in rivista) (Prodotto della ricerca)
- Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase. (Articolo in rivista) (Prodotto della ricerca)
- Slow-, Tight-Binding HIV-1 Reverse Transcriptase Non-Nucleoside Inhibitors Highly Active against Drug-Resistant Mutants. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- APOBEC deaminases as cellular antiviral factors: a novel natural host defense mechanism. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Toward the discovery of novel anti-HIV drugs. Second-generation inhibitors of the cellular ATPase DDX3 with improved anti-HIV activity: synthesis, structure-activity relationship analysis, cytotoxicity studies, and target validation. (Articolo in rivista) (Prodotto della ricerca)
- Mechanism of interaction of novel indolylarylsulfone derivatives with K103N and Y181I mutant HIV-1 reverse transcriptase in complex with its substrates. (Articolo in rivista) (Prodotto della ricerca)
- The PDZ-Ligand and Src-Homology Type 3 Domains of Epidemic Avian Influenza Virus NS1 Protein Modulate Human Src Kinase Activity during Viral Infection. (Articolo in rivista) (Prodotto della ricerca)
- Human Immunodeficiency Virus (HIV-1) Auxiliary Protein Vif and Cellular APOBEC Deaminases: Their Roles Unveiled? (Articolo in rivista) (Prodotto della ricerca)
- DNA polymerases and Diseases. (Articolo in rivista) (Prodotto della ricerca)
- Repair and translesion DNA polymerases as anticancer drug targets. (Articolo in rivista) (Prodotto della ricerca)
- Interazione diretta tra PARP1, PCNA e p21: un possibile ruolo nella regolazione di PCNA nella riparazione del DNA (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- La proteina Vif del virus HIV-1 e un fattore accessorio per la trascrittasi inversa (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Role of the HIV-1 auxiliary protein Vif in the retrotranscription process (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- DNA polymerase lambda: a molecular Swiss army knife (Comunicazione a convegno) (Prodotto della ricerca)
- Arylthiopyrrole (ATP) Derivatives as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Diketo hexenoic acid (DKHA) derivatives: the first class of selective non-nucleoside inhibitors of mammalian terminal deoxynucleotidyl transferases endowed with cytotoxic effect against leukemic cells. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Tyrosine Kinase inhibitors active against a wide panel of tumor cell lines. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Expression, characterization of human DDX3 protein and construction of mutants. (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Natural resistance to HIV infection: role of APOBEC. (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Roles of the human proteins PCNA, RP-A and Fen-1 in avoiding functional redundance between human DNA polymerases b and l in genomic stability safeguarding. (Comunicazione a convegno) (Prodotto della ricerca)
- Inhibitors of human immunodeficiency virus-1 replication targeting the human dead-box polypeptide 3 (DDX3) RNA helicase (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Interazione diretta tra PARP-1, PCNA e p21: un possible ruolo nella regolazione di PCNA dalla replicazione alla riparazione del DNA? (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Modulation of the (in)fidelity of DNA polymerase lamda by PCNA and RP-A (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Effetti di differenti mutazioni nella RT di HIV-1 sulla fitness virale e sulla resistenza multipla a inibitori nucleosidici e non-nucleosidici (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- DNA polymerase lamda: mechanism of frameshift generation and regulation of its terminal-transferase and polymerase activities by PCNA and RP-A (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Human DNA polymerase lambda binds to the front side of PCNA through a conserved HhH-motif and its binding is regulated by p21 (Comunicazione a convegno) (Prodotto della ricerca)
- DNA polymerase lambda: mechanism of frameshift generation and regulation of its terminal-transferase and polymerase activities by PCNA an (Comunicazione a convegno) (Prodotto della ricerca)
- Nevirapine Resistance Mutation at Codon 181 of the HIV-1 Reverse Transcriptase Confers Stavudine Resistance by Increasing Nucleotide Substrate Discrimination and Phosphorolytic Activity. (Comunicazione a convegno) (Prodotto della ricerca)
- DNA polymerases and cancer (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Functional domains of human DNA polymerase l: a molecular anatomy approach (Comunicazione a convegno) (Prodotto della ricerca)
- Human DNA polymerase l binds to the front side of PCNA through a conserved HhH-motif and its binding is regulated by p21 (Comunicazione a convegno) (Prodotto della ricerca)
- DNA polymerase l interacts with PCNA in normal and translesion DNA synthesis (Comunicazione a convegno) (Prodotto della ricerca)
- Quality control of DNA: DNA polymerase lambda functions in DNA synthesis over damaged and depurinated DNA (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- PCNA, PARP-1 and p21: a dynamic exchange of partners. (Comunicazione a convegno) (Prodotto della ricerca)
- Mutations coferring interclass antiretroviral drug resistance and their impact on HIV-1 replicative capacity (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Novel NNRTIs (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Second generation PBOs show enantioselective binding to the catalytic complex of HIV-1 RT wt and drug resistant mutants. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Characterization of novel N,N-DABOs as effective tight binding non-nucleoside inhibitors of HIV-1 RT. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- Novel HIV-1 NNRTIs with reduced loss of potency against common drug-resistant mutations. (Abstract/Poster in atti di convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1302)
- through a conserved helix-hairpin-helix motif and its binding is regulated by p21. (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Identificazione di nuovi target e di nuove molecole antitumorali e antivirali (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Two birds with a stone: from single- to multi-target drugs in cancer therapy (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Una cura per l'AIDS: illusioni, certezze e nuove speranze (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- DNA polymerase lambda specifically bridges and extends DNA ends containing microhomoloy regions (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Biochemical Approach of PCNA1 and PCNA2 proteins interaction with DNA pol lambda of Arabidopsis thaliana (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- Biochemical Approach of PCNA1 and PCNA2 proteins interaction with DNA pol lambda of Arabidopsis thaliana (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- DNA polymerase lambda specifically bridges and extends DNA ends containing microhomoloy regions (Abstract/Poster in atti di convegno) (Prodotto della ricerca)
- DNA polymerases and Diseases (Monografia o trattato scientifico) (Prodotto della ricerca)
- Intrinsic and extrinsic determinants of DNA polymerases fidelity in normal and translesion synthesis (Contributo in volume (capitolo o saggio)) (Prodotto della ricerca)
- DNA polymerases: discovery, characterization and functions in cellular DNA transactions (Monografia o trattato scientifico) (Prodotto della ricerca)
- Final Report FP5 EU Project DNA replication and Biotechnology (Rapporti progetti di ricerca) (Prodotto della ricerca)
- 6-Vinyl pyrimidine and pyrimidinone derivatives and the use thereof. (Brevetto) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1601)
- Ruolo funzionale della proteina Vif di HIV-1 nel processo di retrotrascrizione del genoma virale (Rapporti progetti di ricerca) (Prodotto della ricerca)
- Final Report IV National AIDS Program: Project 30D.72 (Rapporti progetti di ricerca) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1714)
- Studio delle farmaco-resistenze crociate della RT di HIV-1 a inibitori nucleosidici e non-nucleosidici e sviluppo di nuovi analoghi L-nucleosidici anti-HIV a bassa citotossicità (Rapporti progetti di ricerca) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1714)
- Final Report FP6 EU Project Targeting Replication and Integration of HIV-TRIoH (Rapporti progetti di ricerca) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1714)
- Indolylarylsulfones Bearing Natural and Unnatural Amino Acids. Discovery of Potent Inhibitors of HIV-1 Non-Nucleoside Wild Type and Resistant Mutant Strains Reverse Transcriptase and Coxsackie B4 Virus (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Design, synthesis, biological evaluation, and molecular modeling studies of TIBO-like cyclic sulfones as non-nucleoside HIV-1 reverse transcriptase inhibitors. (Articolo in rivista) (Prodotto della ricerca)
- Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: towards the next generation HIV-1 inhibitors (Articolo in rivista) (Prodotto della ricerca)
- 2-(Alkyl/aryl)amino-6-benzylpyrimidin-4(3H)-ones as inhibitors of wild-type and mutant HIV-1: enantioselectivity studies (Articolo in rivista) (Prodotto della ricerca)
- Human DNA Polymerase beta, but Not lambda, Can Bypass a 2-Deoxyribonolactone Lesion Together with Proliferating Cell Nuclear Antigen (Articolo in rivista) (Prodotto della ricerca)
- Tyrosine kinases as essential cellular cofactors and potential therapeutic targets for human immunodeficiency virus infection (Articolo in rivista) (Prodotto della ricerca)
- Microhomology-mediated DNA strand annealing and elongation by human DNA polymerases ? and ? on normal and repetitive DNA sequences (Articolo in rivista) (Prodotto della ricerca)
- New targets and new drugs: from in silico planning to in vivo testing (Articolo in rivista) (Prodotto della ricerca)
- New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors (Articolo in rivista) (Prodotto della ricerca)
- DNA elongation by the human DNA polymerase ? polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Synthesis, biological activity, and ADME properties of novel S-DABOs/N-DABOs as HIV reverse transcriptase inhibitors (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- The power of enzyme kinetics in the drug development process (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- New in silico and conventional in vitro approaches to advance HIV drug discovery and design (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Occhio ai virus (Monografia o trattato scientifico) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1401)
- NEW 4-SUBSTITUTED DERIVATIVES OF PYRAZOLO[3,4-d]PYRIMIDINE AND PYRROLO[2,3-d]PYRIMIDINE AND USES THEREOF (Brevetto) (Prodotto della ricerca)
- Reconstitution of the base excision repair pathway for 7,8-dihydro-8-oxoguanine with purified human proteins. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- CRYSTAL STRUCTURE OF THE HIV-1 REVERSE TRANSCRIPTASE BOUND TO A NUCLEOTIDE-COMPETITIVE REVERSE TRANSCRIPTASE INHIBITOR AND THE USE THEREOF (Brevetto) (Prodotto della ricerca)
- COMPOUNDS WITH DDX3 INHIBITORY ACTIVITY AND USES THEREOF (Brevetto) (Prodotto della ricerca)
- Enzymes of DNA metabolism in a patient with the Wiedemann-Rautenstrauch progeroid syndrome. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- 5-Iodo-2'-deoxy-L-uridine and (E)-5-(2-bromovinyl)-2'-deoxy-L-uridine: selective phosphorylation by herpes simplex virus type 1 thymidine kinase, antiherpetic activity, and cytotoxicity studies. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Lack of stereospecificity of some cellular and viral enzymes involved in the synthesis of deoxyribonucleotides and DNA: molecular basis for the antiviral activity of unnatural L-beta-nucleosides. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Aphidicolin inhibits in vitro the activity of pseudorabies virus (PRV) DNA polymerase and in vivo the viral proliferation. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Kinetic studies with N2-phenylguanines and with L-thymidine indicate that herpes simplex virus type-1 thymidine kinase and thymidylate kinase share a common active site. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Novel host-pathogen interactions between human proteins and NS1 of epidemic avian influenza virus (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Targeting host-pathogen interactions in viral infections as a novel therapeutic strategy: lessons from cancer research (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Selective interaction of the human immunodeficiency virus type 1 reverse transcriptase nonnucleoside inhibitor efavirenz and its thio-substituted analog with different enzyme-substrate complexes (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Electron microscopic analysis reveals that replication factor C is sequestered by single-stranded DNA (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Solid phase synthesis of 2,6-disubstituted-4(3H)-pyrimidinones targeting HIV-1 reverse transcriptase (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Silencing of human DNA polymerase lambda causes replication stress and is synthetically lethal with an impaired S phase checkpoint. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Synthesis, properties, and pharmacokinetic studies of N2-phenylguanine derivatives as inhibitors of herpes simplex virus thymidine kinases. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Identification, partial purification and inhibition by guanine analogues of a novel enzymic activity which phosphorylates guanosine to GMP in the protozoan parasite Eimeria tenella (Articolo in rivista) (Prodotto della ricerca)
- The goods and bads of DNA polymerases ? and ? actions on CAG repeats and telomeric DNA sequences (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Auxiliary proteins PCNA, RP-A and 9-1-1 together with Fen-1 avoid functional redundance between human DNA polymerases beta and lambda in promoting genomic integrity (Comunicazione a convegno) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1303)
- Repair DNA polymerases as anticancer drug targets (Abstract/Comunicazione in rivista) (Prodotto della ricerca)
- Photoreactive DNA probes as a tool for studying the translesion synthesis system in mammalian cell extracts (Articolo in rivista) (Prodotto della ricerca)
- Non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis and biological evaluation of novel quinoxalinylethylpyridylthioureas as potent antiviral agents (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- DNA polymerase switching: I. Replication factor C displaces DNA polymerase alpha prior to PCNA loading (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Pyrrolobenzoxazepinone derivatives as non-nucleoside HIV-1 RT inhibitors: Further structure-activity relationship studies and identification of more potent broad-spectrum HIV-1 RT inhibitors with antiviral activity (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Mutant DNA polymerase delta from thermosensitive Schizosaccharomyces pombe strains display reduced stimulation by proliferating cell nuclear antigen (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Stereospecificity of human DNA polymerases alpha, beta, gamma, delta and epsilon, HIV-reverse transcriptase, HSV-1 DNA polymerase, calf thymus terminal transferase and Escherichia coli DNA polymerase I in recognizing D- and L-thymidine 5'-triphosphate as substrate. (Articolo in rivista) (Prodotto della ricerca)
- DNA polymerases as anticancer drug targets (Comunicazione a convegno) (Prodotto della ricerca)
- Current state-of-the-art in preclinical and clinical development of novel non-nucleoside HIV-1 reverse transcriptase inhibitors (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Q145M, a novel HIV-1 reverse transcriptase mutation conferring resistance to nucleoside and non-nucleoside reverse transcriptase inhibitors (Articolo in rivista) (Prodotto della ricerca)
- Molecular basis for the enantioselectivity of HIV-1 reverse transcriptase: role of the 3 '-hydroxyl group of the L-(beta)-ribose in chiral discrimination between D- and L-enantiomers of deoxy- and dideoxy-nucleoside triphosphate analogs (Articolo in rivista) (Prodotto della ricerca)
- Probing interactions between HIV-1 reverse transcriptase and its DNA substrate with backbone-modified nucleotides (Articolo in rivista) (Prodotto della ricerca)
- Dual mode of interaction of DNA polymerase epsilon with proliferating cell nuclear antigen in primer binding and DNA synthesis (Articolo in rivista) (Prodotto della ricerca)
- Structural determinants of HIV-1 reverse transcriptase stereoselectivity towards (beta)-L-deoxy- and dideoxy pyrimidine nucleoside triphosphates: Molecular basis for the combination of L-dideoxynucleoside analogs with nonnucleoside inhibitors in anti HIV chemotherapy. (Articolo in rivista) (Prodotto della ricerca)
- The solution structure of functionally active human proliferating cell nuclear antigen determined by small-angle neutron scattering (Articolo in rivista) (Prodotto della ricerca)
- Resistance to Nevirapine of HIV-1 reverse transcriptase mutants: Loss of stabilizing interactions and thermodynamic or steric barriers are induced by different single amino acid substitutions (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Cytotoxicity of alpha-dicarbonyl compounds submitted to in vitro simulated digestion process (Articolo in rivista) (Prodotto della ricerca)
- The Arabidopsis STRESS RESPONSE SUPPRESSOR DEAD-box RNA helicases are nucleolar- and chromocenter-localized proteins that undergo stress-mediated relocalization and are involved in epigenetic gene silencing (Articolo in rivista) (Prodotto della ricerca)
- New indolylarylsulfones as highly potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors (Articolo in rivista) (Prodotto della ricerca)
- Exploring the Role of 2-Chloro-6-fluoro Substitution in 2-Alkylthio-6-benzyl-5-alkylpyrimidin-4(3H)-ones: Effects in HIV-1-Infected Cells and in HIV-1 Reverse Transcriptase Enzymes (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Exploring the chemical space around the privileged pyrazolo[3,4-d] pyrimidine scaffold: Toward novel allosteric inhibitors of T315I-mutated Abl (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Pyrazolo[3,4-d]pyrimidine prodrugs: Strategic optimization of the aqueous solubility of dual Src/Abl inhibitors (Articolo in rivista) (Prodotto della ricerca)
- LACK OF STEREOSPECIFICITY OF SUID PSEUDORABIES VIRUS THYMIDINE KINASE (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- HCV-targeted antivirals: Current status and future challenges (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- What makes Y family Pols potential candidates for molecular targeted therapies and novel biotechnological applications (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
- Indolylarylsulfones Carrying a Heterocyclic Tail as Very Potent and Broad Spectrum HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors (Articolo in rivista) (Prodotto della ricerca)
- DNA polymerase delta-interacting protein 2 is a processivity factor for DNA polymerase lambda during 8-oxo-7,8-dihydroguanine bypass. (Articolo in rivista) (Prodotto della ricerca)
- New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: Discovery, characterization, and crystal structure in complex with the target (Articolo in rivista) (Prodotto della ricerca)
- Identification of Hck Inhibitors As Hits for the Development of Antileukemia and Anti-HIV Agents (Articolo in rivista) (Prodotto della ricerca)
- Design, synthesis, and biological evaluation of pyrazolo[3,4-d]pyrimidines active in vivo on the Bcr-Abl T315I mutant (Articolo in rivista) (Prodotto della ricerca)
- AIDS: la verità negata (Monografia o trattato scientifico) (Prodotto della ricerca)
- Combining X-ray crystallography and molecular modeling toward the optimization of pyrazolo[3,4-d ]pyrimidines as potent c-Src inhibitors active in vivo against neuroblastoma (Articolo in rivista) (Prodotto della ricerca)
