Journal of medicinal chemistry

Label

• Journal of medicinal chemistry (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Synthesis and preliminary in vitro biological evaluation of 4-[(4-hydroxyphenyl)sulfanyl]but-3-en-2-one, a 4-mercaptophenol derivative designed as a novel bifunctional antimelanoma agent (Articolo in rivista) (Prodotto della ricerca)
• Phenyl-imidazo[1,2-a]pyridine compounds containing hydrophilic groups as potent and selective ligands for peripheral benzodiazepine receptors: synthesis, binding affinity and electrophysiological studies (Articolo in rivista) (Prodotto della ricerca)
• Cisplatinum and Transplatinum Complexes with Benzyliminoether Ligands. Synthesis, Characterization, Structure-Activity Relationships, in Vitro and in Vivo Antitumor Efficacy (Articolo in rivista) (Prodotto della ricerca)
• Molecular Basis of Antimony Treatment in Leishmaniasis (Articolo in rivista) (Prodotto della ricerca)
• N-acylvanillamides: development of an expeditious synthesis and discovery of new acyl templates for powerful activation of the vanilloid receptor. (Articolo in rivista) (Prodotto della ricerca)
• Tetrahydrolipstatin analogues as modulators of endocannabinoid 2-arachidonoylglycerol metabolism (Articolo in rivista) (Prodotto della ricerca)
• Discovery of Subnanomolar Arginine-Glycine-Aspartate-Based aVb3/aVb5 Integrin Binders Embedding 4-Aminoproline Residues. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• In vitro antitumor activity of the water soluble copper(I) complexes bearing the tris(hydroxymethyl)phosphine ligand (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues: Part 2 (Articolo in rivista) (Prodotto della ricerca)
• Water stability and cytotoxic activity relationship of a series of ferrocenium derivatives. ESR insights on the radical production during the degradation process (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Labeling and evaluation of N-[11C]methylated quinoline-2-carboxamides as potential radioligands for visualization of peripheral benzodiazepine receptors. (Articolo in rivista) (Prodotto della ricerca)
• The taming of capsaicin. Reversal of the vanilloid activity of N-acylvanillamines by aromatic iodination (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Conformation-Activity Relationship of Neuropeptide S and Some Structural Mutants:Helicity Affects Their Interaction with the Receptor. (Articolo in rivista) (Prodotto della ricerca)
• Biochemical and Structural Analysis of the Binding Determinants of a Vascular Endothelial Growth Factor Receptor Peptidic Antagonist (Articolo in rivista) (Prodotto della ricerca)
• Investigations on the 4-quinolone-3-carboxylic acid motif. 2. Synthesis and structure-activity relationship of potent and selective cannabinoid-2 receptor agonists endowed with analgesic activity in vivo (Articolo in rivista) (Prodotto della ricerca)
• Highly Selective Fluorescent Analogue of the Potent d-Opioid Receptor Antagonist Dmt-Tic (Articolo in rivista) (Prodotto della ricerca)
• Synthesis, Characterization and Comparative In Vitro Cytotoxicity Studies of Platinum(II), Palladium(II) and Gold(III) Methylsarcosinedithiocarbamate Complexes (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Investigations on the 4-quinolone-3-carboxylic acid motif. 3. Synthesis, structure-affinity relationships, and pharmacological characterization of 6-substituted 4-quinolone-3-carboxamides as highly selective cannabinoid-2 receptor ligands. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Tricyclic pyrazoles. 3. Synthesis, biological evaluation, and molecular modeling of analogues of the cannabinoid antagonist 8-chloro-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide. (Articolo in rivista) (Prodotto della ricerca)
• Novel [Tc-99m(III)(PS)(2)(Ln)] Mixed-Ligand Compounds (PS = Phosphinothiolate; L = Dithiocarbamate) Useful in Design and Development of Tc-III-Based Agents: Synthesis, in Vitro, and ex Vivo Biodistribution Studies (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Chemical Behavior and in Vitro Activity of Mixed Phosphine Gold(I) Compounds on Melanoma Cell Lines. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Synthesis and Biological Evaluation of Direct Thrombin Inhibitors Bearing 4-(Piperidin-1-yl)pyridine at the P1 Position with Potent Anticoagulant Activity (Articolo in rivista) (Prodotto della ricerca)
• Rational design, synthesis, and pharmacological properties of new 1,8-naphthyridin-2(1H)-on-3-carboxamide derivatives as highly selective cannabinoid-2 receptor agonists (Articolo in rivista) (Prodotto della ricerca)
• Cationic [99mTcIII(DIARS)2(SR)2]+ complexes as potential myocardial perfusion imaging agents (DIARS = o-phenylenebis(dimethylarsine); SR- = thiolate) (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors (Articolo in rivista) (Prodotto della ricerca)
• Cisplatinum and Transplatinum Complexes with Benzyliminoether Ligands; Synthesis, Characterization, Structure-Activity Relationships, and In Vitro and In Vivo Antitumor Efficacy (Articolo in rivista) (Prodotto della ricerca)
• Synthesis, characterization, and in vitro antitumor properties of tris(hydroxymethyl)phosphine copper(I) complexes containing the new bis(1,2,4-triazol-1-yl)acetate ligand (Articolo in rivista) (Prodotto della ricerca)
• Carbonic anhydrase inhibitors: bioreductive nitro-containing sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Polymer-drug conjugates for combination anticancer therapy: investigating the mechanism of action (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Substitution of the Arginine/Leucine Residues in Apidaecin Ib with Peptoid Residues: Effect on Antimicrobial Activity, Cellular Uptake, and Proteolytic Degradation (Articolo in rivista) (Prodotto della ricerca)
• Synthesis, cannabinoid receptor affinity, and molecular modeling studies of substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Homology modelling studies on human galactose-1-phosphate uridylyltransferase and on its galactosemia-related mutant Q188R provide an explanation of molecular effects of the mutation on homo- and heterodimers. (Articolo in rivista) (Prodotto della ricerca)
• Multitarget Drug Design Strategy: Quinone-Tacrine Hybrids Designed To Block Amyloid-beta Aggregation and To Exert Anticholinesterase and Antioxidant Effects (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Parallel Synthesis, Evaluation, and Preliminary Structure-Activity Relationship of 2,5-Diamino-1,4-benzoquinones as a Novel Class of Bivalent Anti-Prion Compound (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Identification of Inhibitors of Drug-Resistant Candida albicans Strains from a Library of Bicyclic Peptidomimetic Compounds (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Mixed steroidal 1,2,4,5-tetraoxanes: antimalarial and antimycobacterial activity (Articolo in rivista) (Prodotto della ricerca)
• Small-molecule targeting of heat shock protein 90 chaperone function: Rational identification of a new anticancer lead (Articolo in rivista) (Prodotto della ricerca)
• Synthesis of stable and Potent d/m Optical Peptides: Analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]OH by Ring-Closing Metathesis (Articolo in rivista) (Prodotto della ricerca)
• Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II. (Articolo in rivista) (Prodotto della ricerca)
• Design, synthesis, and evaluation of hydroxamic acid derivatives as promising agents for the management of Chagas disease (Articolo in rivista) (Prodotto della ricerca)
• Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Exofacial protein thiols as a route for the internalization of Gd(III)-based complexes for magnetic resonance imaging cell labeling (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Targeted biocompatible nanoparticles for the delivery of (-)-epigallocatechin 3-gallate to prostate cancer cells. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Novel nonsubstrate inhibitors of human thymidine phosphorylase, a potential target for tumor-dependent angiogenesis. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Conformational Modifications of gB from Herpes Simplex Virus Type 1 Analyzed by Synthetic Peptides (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Molecular modeling and synthesis of inhibitors of herpes simplex virus type 1 uracil-DNA glycosylase (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Crystal structure of the PPAR-gamma ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Synthesis, properties, and pharmacokinetic studies of N2-phenylguanine derivatives as inhibitors of herpes simplex virus thymidine kinases. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• A New Avenue toward Androgen Receptor Pan-antagonists: C2 Sterically Hindered Substitution of Hydroxy-propanamides (Articolo in rivista) (Prodotto della ricerca)
• Spatial Conformation and Topography of the Tyrosine Aromatic Ring in Substrate Recognition by Protein Tyrosine Kinases. (Articolo in rivista) (Prodotto della ricerca)
• Novel Mixed-Ligand Copper(I) Complexes: Role of Diimine Ligands on Cytotoxicity and Genotoxicity (Articolo in rivista) (Prodotto della ricerca)
• Solution Structure of Mouse Cripto CFC Domain and Its Inactive Variant Trp107Ala. (Articolo in rivista) (Prodotto della ricerca)
• Diarylpyrimidine-Dihydrobenzyloxopyrimidine Hybrids: New, Wide-Spectrum Anti-HIV-1 Agents Active at (Sub)-Nanomolar Level. (Articolo in rivista) (Prodotto della ricerca)
• Stereoselectivity by enantiomeric inhibitors of matrix metalloproteinase-8: new insights from molecular dynamics simulations (Articolo in rivista) (Prodotto della ricerca)
• How a beta-D-Glucoside Side Chain Enhances Binding Affinity to Thrombin of Inhibitors Bearing 2-Chlorothiophene as P1 Moiety: Crystallography, Fragment Deconstruction Study, and Evaluation of Antithrombotic Properties (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• STRUCTURE-ACTIVITY-RELATIONSHIPS OF N-2-SUBSTITUTED GUANINES AS INHIBITORS OF HSV1 AND HSV2 THYMIDINE KINASES (Articolo in rivista) (Prodotto della ricerca)
• QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS OF N-2-PHENYLGUANINES AS INHIBITORS OF HERPES-SIMPLEX VIRUS THYMIDINE KINASES (Articolo in rivista) (Prodotto della ricerca)
• Design and Synthesis of Novel Indole b-Diketo Acid Derivatives as HIV-1 Integrase Inhibitors (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Endomorphin-1 Analogues Containing -Proline Are -Opioid Receptor Agonists and Display Enhanced Enzymatic Hydrolysis Resistance (Articolo in rivista) (Prodotto della ricerca)
• A New Biotin Derivative?DOTA Conjugate as a Candidate for Pretargeted Diagnosis and Therapy of Tumors (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Characterization of a Designed Vascular Endothelial Growth Factor Receptor Antagonist Helical Peptide with Antiangiogenic Activity in Vivo (Articolo in rivista) (Prodotto della ricerca)
• Synthesis and biological evaluation of 2 '-methyl taxoids derived from baccatin III and 14 beta-OH-baccatin III 1,14-carbonate (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Ester-based precursors to increase the bioavailability of quercetin (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Extra Binding Region Induced by Non-Zinc Chelating Inhibitors into the S-1 ' Subsite of Matrix Metalloproteinase 8 (MMP-8) (Articolo in rivista) (Prodotto della ricerca)
• Structural Insight into Peroxisome Proliferator-Activated Receptor ³ Binding of Two Ureidofibrate-Like Enantiomers by Molecular Dynamics, Cofactor Interaction Analysis, and Site-Directed Mutagenesis (Articolo in rivista) (Prodotto della ricerca)
• Probing Torpedo californica acetylcholinesterase catalytic gorge with two novel bis-functional galanthamine derivatives. (Articolo in rivista) (Prodotto della ricerca)
• Pyrrolobenzoxazepinone derivatives as non-nucleoside HIV-1 RT inhibitors: Further structure-activity relationship studies and identification of more potent broad-spectrum HIV-1 RT inhibitors with antiviral activity (Articolo in rivista) (Prodotto della ricerca)
• Folic Acid-Conjugated Europium Complexes as Luminescent Probes for Selective Targeting of Cancer Cells (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• 2-(Alkyl/aryl)amino-6-benzylpyrimidin-4(3H)-ones as inhibitors of wild-type and mutant HIV-1: enantioselectivity studies (Articolo in rivista) (Prodotto della ricerca)
• Activity of rat cytosolic thioredoxin reductase is strongly decreased by (Articolo in rivista) (Prodotto della ricerca)
• Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Design, synthesis, and preliminary pharmacological evaluation of new quinoline derivatives as nicotinic ligands. (Articolo in rivista) (Prodotto della ricerca)
• Anthranilic Acid Based CCK1 Receptor Antagonists and CCK-8 Have a Common Step in Their Receptor Desmodynamic Processes (Articolo in rivista) (Prodotto della ricerca)
• Oligonucleotide Analogues as Modulators of the Expression and Function of Noncoding RNAs (ncRNAs): Emerging Therapeutics Applications. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Design, synthesis and binding studies of new potent ligands of cannabinoid receptors (Articolo in rivista) (Prodotto della ricerca)
• Exploring the Role of 2-Chloro-6-fluoro Substitution in 2-Alkylthio-6-benzyl-5-alkylpyrimidin-4(3H)-ones: Effects in HIV-1-Infected Cells and in HIV-1 Reverse Transcriptase Enzymes (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Platinum Complexes Can Inhibit Matrix Metalloproteinase Activity: Platinum- diethyl[(methylsulfinyl)methyl]phosphonate Complexes as Inhibitors of Matrix Metalloproteinases 2, 3, 9 and 12 (Articolo in rivista) (Prodotto della ricerca)
• 11C-Labelling of N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Development of the first potential covalent inhibitors of anandamide cellular uptake (Articolo in rivista) (Prodotto della ricerca)
• Activity of rat cytosolic thioredoxin reductase is strongly decreased by trans-[bis(2-amino-5- methylthiazole)tetrachlororuthenate(III)]: first report of relevant thioredoxin reductase inhibition for a ruthenium compound. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• A nonpeptide NK1 receptor agonist showing subpicomolar affinity. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists able ti up regulate the mitochondrial carnitine shuttle system gene expression. (Articolo in rivista) (Prodotto della ricerca)
• Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Novel 1-[2-(diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. A structure-activity relationship investigation. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Design and Synthesis of 2-Heterocyclyl-3-arylthio-1H-indoles as Potent Tubulin Polymerization and Cell Growth Inhibitors with Improved Metabolic Stability (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• New Furan Side Tetracyclic Allopsoralen Derivatives: Synthesis and Photobiological Evaluation. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Synthesis, structure-activity relationships at the GABA(A) receptor in rat brain, and differential electrophysiological profile at the recombinant human GABA(A) receptor of a series of substituted 1,2-diphenylimidazoles (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• 1,3,4-Oxadiazole-Containing Histone Deacetylase Inhibitors: Anticancer Activities in Cancer Cells (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Structure-activity relationships and effects on neuroactive steroid synthesis in a series of 2-phenylimidazo[1,2-a]pyridineacetamide peripheral benzodiazepine receptors ligands (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Unichiral 2-(2 '-Pyrrolidinyl)-1,4-benzodioxanes: the 2R,2 ' S Diastereomer of the N-Methyl-7-hydroxy Analogue Is a Potent alpha 4 beta 2-and alpha 6 beta 2-Nicotinic Acetylcholine Receptor Partial Agonist (Articolo in rivista) (Prodotto della ricerca)
• Design, Synthesis, Biological Activity, and ADME Properties of Pyrazolo[3,4-d]pyrimidines Active in Hypoxic Human Leukemia Cells: A Lead Optimization Study. (Articolo in rivista) (Prodotto della ricerca)
• Carbonic Anhydrase Inhibitors. Comparison of Aliphatic Sulfamate/Bis-sulfamate Adducts with Isozymes II and IX as a Platform for Designing Tight-Binding, More Isoform-Selective Inhibitors (Articolo in rivista) (Prodotto della ricerca)
• Solution structure of the supramolecular adduct between a liver cytosolic bile acid binding protein and a bile acid-based gadolinium(III)-chelate, a potential hepatospecific magnetic resonance imaging contrast agent. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Novel and selective alpha(v)beta3 receptor peptide antagonist: design, synthesis, and biological behavior. (Articolo in rivista) (Prodotto della ricerca)
• A New Class of Antitumor trans-Amine-Amidine-Pt(II) Cationic Complexes: Influence of Chemical Structure and Solvent on in Vitro and in Vivo Tumor Cell Proliferation (Articolo in rivista) (Prodotto della ricerca)
• New N-arachidonoylserotonin analogues with potential 'dual' mechanism of action against pain. (Articolo in rivista) (Prodotto della ricerca)
• New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Carbonic anhydrase inhibitors: hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX (Articolo in rivista) (Prodotto della ricerca)
• Combining X-ray crystallography and molecular modeling toward the optimization of pyrazolo[3,4-d ]pyrimidines as potent c-Src inhibitors active in vivo against neuroblastoma (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• 2-Substituted Estradiol Bis-sulfamates, Multitargeted Antitumor Agents: Synthesis, In Vitro SAR, Protein Crystallography, and In Vivo Activity (Articolo in rivista) (Prodotto della ricerca)
• Indolylarylsulfones as HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: New Cyclic Substituents at Indole-2-carboxamide. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Synthesis, characterization, and preliminary in vivo tests of new poly(ethylene glycol) conjugates of the antitumor agent 10-amino-7-ethylcamptothecin. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• SYNTHESIS, Characterization and biological evaluation of ureidofibrate-like derivatives endowed with Peroxisome Proliferator-Activated Receptor Activity (Articolo in rivista) (Prodotto della ricerca)
• New Pyrrole Derivatives with Potent Tubulin Polymerization Inhibiting Activity As Anticancer Agents Including Hedgehog-Dependent Cancer (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Investigations on the 4-quinolone-3-carboxylic acid motif. 4. Identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• In Vitro and in Vivo Anticancer Activity of Copper(I) Complexes with Homoscorpionate Tridentate Tris(pyrazolyl)borate and Auxiliary Monodentate Phosphine Ligands (Articolo in rivista) (Prodotto della ricerca)
• Structure-activity relationships in carboxamide derivatives based on the targeted delivery of radionuclides and boron atoms by means of peripheral benzodiazepine receptor ligands. (Articolo in rivista) (Prodotto della ricerca)
• New 2-Aryloxy-3-phenyl-propanoic Acids As Peroxisome Proliferator-Activated Receptors alpha/gamma Dual Agonists with Improved Potency and Reduced Adverse Effects on skeletal muscle function (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Indolylarylsulfones Bearing Natural and Unnatural Amino Acids. Discovery of Potent Inhibitors of HIV-1 Non-Nucleoside Wild Type and Resistant Mutant Strains Reverse Transcriptase and Coxsackie B4 Virus (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Resorcinol-sn-Glycerol Derivatives: Novel 2-Arachidonoylglycerol Mimetics Endowed with High Affinity and Selectivity for Cannabinoid Type 1 Receptor (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Novel hypotensive agents from Verbesina caracasana. 8. Synthesis and pharmacology of (3,4-dimethoxycinnamoyl)-N1-agmatine and synthetic analogues (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Antimicrobial Peptides: Synthesis and Antibacterial Activity of Linear and Cyclic Drosocin and Apidaecin 1b Analogues (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Inhibition of Subgenomic Hepatitis C Virus RNA Replication by Acridone Derivatives: Identification of an NS3 Helicase Inhibitor. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Antitumor Activity of the Mixed Phosphine Gold Species Chlorotriphenylphosphine-1,3-bis(diphenylphosphino)propanegold(I). (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Non-Natural Macrocyclic Inhibitors of Histone Deacetylases: Design, Synthesis, and Activity (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Structure-activity relationship in 4-aminoquinoline antiplasmodials. The role of the group at the 7-position (Articolo in rivista) (Prodotto della ricerca)
• N-2 PHENYLDEOXYGUANOSINE A NOVEL SELECTIVE INHIBITOR OF HERPES SIMPLEX THYMIDINE KINASE (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Small-molecule inhibitors of histone acetyltransferase activity: identification and biological properties. (Articolo in rivista) (Prodotto della ricerca)
• Structural determinants of Torpedo californica acetylcholinesterase inhibition by the novel and orally active carbamate based anti-alzheimer drug ganstigmine (CHF-2819) (Articolo in rivista) (Prodotto della ricerca)
• Novel inhibitors of mitochondrial respiratory chain: endoperoxides from the tunicate Stolonica socialis (Articolo in rivista) (Prodotto della ricerca)
• Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates. (Articolo in rivista) (Prodotto della ricerca)
• Synthesis and Biological Properties of Novel 2-Aminopyrimidin-4(3H)-ones Highly Potent against HIV-1 Mutant Strains. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Tricyclic pyrazoles. 4. Synthesis and biological evaluation of analogues of the robust and selective CB2 cannabinoid ligand 1-(2',4'-dichlorophenyl)-6-methyl-N-piperidin-1-yl-1,4-dihydroindeno[1,2-c]pyrazo le-3-carboxamide (Articolo in rivista) (Prodotto della ricerca)
• Indolyl aryl sulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: role of two halogen atoms at the indole ring in developing new analogues with improved antiviral activity. (Articolo in rivista) (Prodotto della ricerca)
• Discovery of Salermide-Related Sirtuin Inhibitors: Binding Mode Studies and Antiproliferative Effects in Cancer Cells Including Cancer Stem Cells (Articolo in rivista) (Prodotto della ricerca)
• New Arylthioindoles and Related Bioisosteres at the Sulfur Bridging Group. 4. Synthesis, Tubulin Polymerization, Cell Growth Inhibition, and Molecular Modeling Studies. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Synthesis, binding, and modeling studies of new cytisine derivatives, as ligands for neuronal nicotinic acetylcholine receptor subtypes. (Articolo in rivista) (Prodotto della ricerca)
• Discovery of chiral cyclopropyl dihydro-alkylthio-benzyl-oxopyrimidine (S-DABO) derivatives as potent HIV-1 reverse transcriptase inhibitors with high activity against clinically relevant mutants. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Dihydro-alkylthio-benzyl-oxopyrimidines as inhibitors of reverse transcriptase: synthesis and rationalization of the biological data on both wild-type enzyme and relevant clinical mutants. (Articolo in rivista) (Prodotto della ricerca)
• Design, molecular modeling, synthesis, and anti-HIV-1 activity of new indolyl aryl sulfones. Novel derivatives of the indole-2-carboxamide. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4' chlorophenyl)thiazol-2-yl)hydrazone. (Articolo in rivista) (Prodotto della ricerca)
• A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors. (Articolo in rivista) (Prodotto della ricerca)
• Grafting Aminocyclopentane Carboxylic Acids onto the RGD Tripeptide Sequence Generates Low Nanomolar aVb3/aVb5 Integrin Dual Binders. (Articolo in rivista) (Prodotto della ricerca)
• Indolylarylsulfones Carrying a Heterocyclic Tail as Very Potent and Broad Spectrum HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Mechanisms of cytotoxicity of selected organogold(III) compounds (Articolo in rivista) (Prodotto della ricerca)
• Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Pharmacophore modeling and molecular docking led to the discovery of inhibitors of human immunodeficiency virus-1 replication targeting the human cellular aspartic acid-glutamic acid-alanine-aspartic acid box polypeptide 3. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Crystal structures of the vitamin D nuclear receptor liganded with the vitamin D side chain analogues calcipotriol and seocalcitol, receptor agonists of clinical importance. Insights into a structural basis for the switching of calcipotriol to a receptor (Articolo in rivista) (Prodotto della ricerca)
• Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines. (Articolo in rivista) (Prodotto della ricerca)
• 5-Alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones, a series of anti-HIV-1 agents of the dihydro-alkoxy-benzyl-oxopyrimidine family with peculiar structure-activity relationship profile. (Articolo in rivista) (Prodotto della ricerca)
• Efficient Transfection of DNA by Liposomes Formulated with Cationic Gemini Amphiphiles (Articolo in rivista) (Prodotto della ricerca)
• Thiocamptothecin (Articolo in rivista) (Prodotto della ricerca)
• Arylthioindole Inhibitors of Tubulin Polymerization. 3. Biological Evaluation, Structure-Activity Relationships and Molecular Modeling Studies. (Articolo in rivista) (Prodotto della ricerca)
• Synthesis and Evaluation of Neuroprotective alpha,beta-Unsaturated Aldehyde Scavenger Histidyl-Containing Analogues of Carnosine (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Indole-Derived Psammaplin A Analogues as Epigenetic Modulators with Multiple Inhibitory Activities. (Articolo in rivista) (Prodotto della ricerca)
• BENZO[C]QUINOLIZIN-3-ONES: A NOVEL CLASS OF POTENT AND SELECTIVE NONSTEROIDAL INHIBITORS OF HUMAN STEROID 5?-REDUCTASE 1 (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• New Insight into the Central Benzodiazepine Receptor-Ligand Interactions: Design, Synthesis, Biological Evaluation, and Molecular Modeling of 3-Substituted 6-Phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and Related Compounds (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Simplified analogues of immucillin-G retain potent human purine nucleoside phosphorylase inhibitory activity. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Emerging Protein Targets for Anticancer Metallodrugs: Inhibition of Thioredoxin Reductase and Cathepsin B by Antitumor Ruthenium (II)-Arene Compounds. (Articolo in rivista) (Prodotto della ricerca)
• Modulation of cell differentiation, proliferation, and tumor growth by dihydrobenzyloxopyrimidine non-nucleoside reverse transcriptase inhibitors (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Identification of a Novel Pyrazolo[3,4-d]pyrimidine Able To Inhibit Cell Proliferation of a Human Osteogenic Sarcoma in Vitro and in a Xenograft Model in Mice. (Articolo in rivista) (Prodotto della ricerca)
• Inclusion of a Photosensitizier in Liposomes Formed by DMPC/Gemini Surfactant: Correlation between Physicochemical and Biological Features of the Complexes (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Computational strategies in discovering novel non-nucleoside inhibitors of HIV-1 RT. (Articolo in rivista) (Prodotto della ricerca)
• Parallel solution-phase and microwave-assisted synthesis of new S-DABO derivatives endowed with subnanomolar anti-HIV-1 activity. (Articolo in rivista) (Prodotto della ricerca)
• Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity. (Articolo in rivista) (Prodotto della ricerca)
• 1-methil-3H-pyrazolo[1-2-a]benzo[1-2-3-4]tetrazin-3-ones, design synthesis and biological activity of new antitumoral agents (Articolo in rivista) (Prodotto della ricerca)
• N-Acylvanillamides (N-AVAM): development of an expeditious synthesis and discovery new acyl templates for powerful activation of the vanilloid (VR1) receptor (Articolo in rivista) (Prodotto della ricerca)
• NMR structural studies of the supramolecular adducts between a liver cytosolic bile acid binding protein and Gd(III)-chelates bearing bile acids residues: molecular determinants of the binding of hepatospecific MRI contrast agent (Articolo in rivista) (Prodotto della ricerca)
• Palmitoyl Derivatives of GpMBP Epitopes: T-Cell Response and Peptidases Susceptibility (Articolo in rivista) (Prodotto della ricerca)
• Inhibition of Herpes simplex virus thymidine kinases by 2-Phenylamino-6-oxopurines and related compounds: Structure-Activity Relationships and antiherpetic activity in vivo. (Articolo in rivista) (Prodotto della ricerca)
• Synthesis and Biological Evaluation (in Vitro and in Vivo) of Cyclic Arginine-Glycine-Aspartate (RGD) Peptidomimetic-Paclitaxel Conjugates Targeting Integrin alphaVbeta3 (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Pan-Histone Demethylase Inhibitors Simultaneously Targeting Jumonji C and Lysine-Specific Demethylases Display High Anticancer Activities (Articolo in rivista) (Prodotto della ricerca)
• 1,4-Dioxane, a Suitable Scaffold for the Development of Novel M-3 Muscarinic Receptor Antagonists (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• New resorcinol-anandamide \"hybrids\" as potent cannabinoid receptor ligands endowed with antinociceptive activity in vivo (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Oxyhomologs of anandamide and related endolipids. Chemoselective synthesis and biological activity (Articolo in rivista) (Prodotto della ricerca)

Alternative label

• Journal of medicinal chemistry. (literal)
• J. of med. chem. (literal)

Language

• eng (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#issn

• 0022-2623 (literal)

Preferred label

• Journal of medicinal chemistry (literal)

Publisher

• American Chemical Society, [Easton, Pa.] : USA (literal)

Incoming links:

Rivista

• Molecular Basis of Antimony Treatment in Leishmaniasis (Articolo in rivista) (Prodotto della ricerca)
• Carbonic anhydrase inhibitors: hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX (Articolo in rivista) (Prodotto della ricerca)
• 2-Substituted Estradiol Bis-sulfamates, Multitargeted Antitumor Agents: Synthesis, In Vitro SAR, Protein Crystallography, and In Vivo Activity (Articolo in rivista) (Prodotto della ricerca)
• Novel and selective alpha(v)beta3 receptor peptide antagonist: design, synthesis, and biological behavior. (Articolo in rivista) (Prodotto della ricerca)
• Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Biochemical and Structural Analysis of the Binding Determinants of a Vascular Endothelial Growth Factor Receptor Peptidic Antagonist (Articolo in rivista) (Prodotto della ricerca)
• N-Acylvanillamides (N-AVAM): development of an expeditious synthesis and discovery new acyl templates for powerful activation of the vanilloid (VR1) receptor (Articolo in rivista) (Prodotto della ricerca)
• Design and Synthesis of Novel Indole b-Diketo Acid Derivatives as HIV-1 Integrase Inhibitors (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Spatial Conformation and Topography of the Tyrosine Aromatic Ring in Substrate Recognition by Protein Tyrosine Kinases. (Articolo in rivista) (Prodotto della ricerca)
• Chemical Behavior and in Vitro Activity of Mixed Phosphine Gold(I) Compounds on Melanoma Cell Lines. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Investigations on the 4-quinolone-3-carboxylic acid motif. 2. Synthesis and structure-activity relationship of potent and selective cannabinoid-2 receptor agonists endowed with analgesic activity in vivo (Articolo in rivista) (Prodotto della ricerca)
• Non-Natural Macrocyclic Inhibitors of Histone Deacetylases: Design, Synthesis, and Activity (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Investigations on the 4-quinolone-3-carboxylic acid motif. 4. Identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Resorcinol-sn-Glycerol Derivatives: Novel 2-Arachidonoylglycerol Mimetics Endowed with High Affinity and Selectivity for Cannabinoid Type 1 Receptor (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Cisplatinum and Transplatinum Complexes with Benzyliminoether Ligands; Synthesis, Characterization, Structure-Activity Relationships, and In Vitro and In Vivo Antitumor Efficacy (Articolo in rivista) (Prodotto della ricerca)
• Synthesis, characterization, and in vitro antitumor properties of tris(hydroxymethyl)phosphine copper(I) complexes containing the new bis(1,2,4-triazol-1-yl)acetate ligand (Articolo in rivista) (Prodotto della ricerca)
• Structural determinants of Torpedo californica acetylcholinesterase inhibition by the novel and orally active carbamate based anti-alzheimer drug ganstigmine (CHF-2819) (Articolo in rivista) (Prodotto della ricerca)
• Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates. (Articolo in rivista) (Prodotto della ricerca)
• New 2-Aryloxy-3-phenyl-propanoic Acids As Peroxisome Proliferator-Activated Receptors alpha/gamma Dual Agonists with Improved Potency and Reduced Adverse Effects on skeletal muscle function (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• SYNTHESIS, Characterization and biological evaluation of ureidofibrate-like derivatives endowed with Peroxisome Proliferator-Activated Receptor Activity (Articolo in rivista) (Prodotto della ricerca)
• Inhibition of Herpes simplex virus thymidine kinases by 2-Phenylamino-6-oxopurines and related compounds: Structure-Activity Relationships and antiherpetic activity in vivo. (Articolo in rivista) (Prodotto della ricerca)
• Computational strategies in discovering novel non-nucleoside inhibitors of HIV-1 RT. (Articolo in rivista) (Prodotto della ricerca)
• Parallel solution-phase and microwave-assisted synthesis of new S-DABO derivatives endowed with subnanomolar anti-HIV-1 activity. (Articolo in rivista) (Prodotto della ricerca)
• Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity. (Articolo in rivista) (Prodotto della ricerca)
• Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Simplified analogues of immucillin-G retain potent human purine nucleoside phosphorylase inhibitory activity. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Identification of a Novel Pyrazolo[3,4-d]pyrimidine Able To Inhibit Cell Proliferation of a Human Osteogenic Sarcoma in Vitro and in a Xenograft Model in Mice. (Articolo in rivista) (Prodotto della ricerca)
• Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Arylthioindole Inhibitors of Tubulin Polymerization. 3. Biological Evaluation, Structure-Activity Relationships and Molecular Modeling Studies. (Articolo in rivista) (Prodotto della ricerca)
• Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines. (Articolo in rivista) (Prodotto della ricerca)
• 5-Alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones, a series of anti-HIV-1 agents of the dihydro-alkoxy-benzyl-oxopyrimidine family with peculiar structure-activity relationship profile. (Articolo in rivista) (Prodotto della ricerca)
• Pharmacophore modeling and molecular docking led to the discovery of inhibitors of human immunodeficiency virus-1 replication targeting the human cellular aspartic acid-glutamic acid-alanine-aspartic acid box polypeptide 3. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Discovery of chiral cyclopropyl dihydro-alkylthio-benzyl-oxopyrimidine (S-DABO) derivatives as potent HIV-1 reverse transcriptase inhibitors with high activity against clinically relevant mutants. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• New Arylthioindoles and Related Bioisosteres at the Sulfur Bridging Group. 4. Synthesis, Tubulin Polymerization, Cell Growth Inhibition, and Molecular Modeling Studies. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Diarylpyrimidine-Dihydrobenzyloxopyrimidine Hybrids: New, Wide-Spectrum Anti-HIV-1 Agents Active at (Sub)-Nanomolar Level. (Articolo in rivista) (Prodotto della ricerca)
• Inclusion of a Photosensitizier in Liposomes Formed by DMPC/Gemini Surfactant: Correlation between Physicochemical and Biological Features of the Complexes (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Tricyclic pyrazoles. 3. Synthesis, biological evaluation, and molecular modeling of analogues of the cannabinoid antagonist 8-chloro-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide. (Articolo in rivista) (Prodotto della ricerca)
• Structure-activity relationships in carboxamide derivatives based on the targeted delivery of radionuclides and boron atoms by means of peripheral benzodiazepine receptor ligands. (Articolo in rivista) (Prodotto della ricerca)
• Synthesis, structure-activity relationships at the GABA(A) receptor in rat brain, and differential electrophysiological profile at the recombinant human GABA(A) receptor of a series of substituted 1,2-diphenylimidazoles (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Structure-activity relationships and effects on neuroactive steroid synthesis in a series of 2-phenylimidazo[1,2-a]pyridineacetamide peripheral benzodiazepine receptors ligands (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• 11C-Labelling of N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• A nonpeptide NK1 receptor agonist showing subpicomolar affinity. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Small-molecule inhibitors of histone acetyltransferase activity: identification and biological properties. (Articolo in rivista) (Prodotto della ricerca)
• Design and Synthesis of 2-Heterocyclyl-3-arylthio-1H-indoles as Potent Tubulin Polymerization and Cell Growth Inhibitors with Improved Metabolic Stability (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Anthranilic Acid Based CCK1 Receptor Antagonists and CCK-8 Have a Common Step in Their Receptor Desmodynamic Processes (Articolo in rivista) (Prodotto della ricerca)
• Exofacial protein thiols as a route for the internalization of Gd(III)-based complexes for magnetic resonance imaging cell labeling (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Novel inhibitors of mitochondrial respiratory chain: endoperoxides from the tunicate Stolonica socialis (Articolo in rivista) (Prodotto della ricerca)
• Antitumor Activity of the Mixed Phosphine Gold Species Chlorotriphenylphosphine-1,3-bis(diphenylphosphino)propanegold(I). (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Antimicrobial Peptides: Synthesis and Antibacterial Activity of Linear and Cyclic Drosocin and Apidaecin 1b Analogues (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Synthesis, characterization, and preliminary in vivo tests of new poly(ethylene glycol) conjugates of the antitumor agent 10-amino-7-ethylcamptothecin. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• New Furan Side Tetracyclic Allopsoralen Derivatives: Synthesis and Photobiological Evaluation. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Design, synthesis and binding studies of new potent ligands of cannabinoid receptors (Articolo in rivista) (Prodotto della ricerca)
• Development of the first potential covalent inhibitors of anandamide cellular uptake (Articolo in rivista) (Prodotto della ricerca)
• Conformation-Activity Relationship of Neuropeptide S and Some Structural Mutants:Helicity Affects Their Interaction with the Receptor. (Articolo in rivista) (Prodotto della ricerca)
• Discovery of Subnanomolar Arginine-Glycine-Aspartate-Based aVb3/aVb5 Integrin Binders Embedding 4-Aminoproline Residues. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Tetrahydrolipstatin analogues as modulators of endocannabinoid 2-arachidonoylglycerol metabolism (Articolo in rivista) (Prodotto della ricerca)
• Synthesis and preliminary in vitro biological evaluation of 4-[(4-hydroxyphenyl)sulfanyl]but-3-en-2-one, a 4-mercaptophenol derivative designed as a novel bifunctional antimelanoma agent (Articolo in rivista) (Prodotto della ricerca)
• New resorcinol-anandamide \"hybrids\" as potent cannabinoid receptor ligands endowed with antinociceptive activity in vivo (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• A New Biotin Derivative?DOTA Conjugate as a Candidate for Pretargeted Diagnosis and Therapy of Tumors (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Identification of Inhibitors of Drug-Resistant Candida albicans Strains from a Library of Bicyclic Peptidomimetic Compounds (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Synthesis, Characterization and Comparative In Vitro Cytotoxicity Studies of Platinum(II), Palladium(II) and Gold(III) Methylsarcosinedithiocarbamate Complexes (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• In vitro antitumor activity of the water soluble copper(I) complexes bearing the tris(hydroxymethyl)phosphine ligand (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• N-acylvanillamides: development of an expeditious synthesis and discovery of new acyl templates for powerful activation of the vanilloid receptor. (Articolo in rivista) (Prodotto della ricerca)
• Stereoselectivity by enantiomeric inhibitors of matrix metalloproteinase-8: new insights from molecular dynamics simulations (Articolo in rivista) (Prodotto della ricerca)
• Crystal structure of the PPAR-gamma ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Novel 1-[2-(diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. A structure-activity relationship investigation. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Design, molecular modeling, synthesis, and anti-HIV-1 activity of new indolyl aryl sulfones. Novel derivatives of the indole-2-carboxamide. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Synthesis and Biological Properties of Novel 2-Aminopyrimidin-4(3H)-ones Highly Potent against HIV-1 Mutant Strains. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Inhibition of Subgenomic Hepatitis C Virus RNA Replication by Acridone Derivatives: Identification of an NS3 Helicase Inhibitor. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Design, Synthesis, Biological Activity, and ADME Properties of Pyrazolo[3,4-d]pyrimidines Active in Hypoxic Human Leukemia Cells: A Lead Optimization Study. (Articolo in rivista) (Prodotto della ricerca)
• Emerging Protein Targets for Anticancer Metallodrugs: Inhibition of Thioredoxin Reductase and Cathepsin B by Antitumor Ruthenium (II)-Arene Compounds. (Articolo in rivista) (Prodotto della ricerca)
• Labeling and evaluation of N-[11C]methylated quinoline-2-carboxamides as potential radioligands for visualization of peripheral benzodiazepine receptors. (Articolo in rivista) (Prodotto della ricerca)
• A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4' chlorophenyl)thiazol-2-yl)hydrazone. (Articolo in rivista) (Prodotto della ricerca)
• Water stability and cytotoxic activity relationship of a series of ferrocenium derivatives. ESR insights on the radical production during the degradation process (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Synthesis and Evaluation of Neuroprotective alpha,beta-Unsaturated Aldehyde Scavenger Histidyl-Containing Analogues of Carnosine (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Grafting Aminocyclopentane Carboxylic Acids onto the RGD Tripeptide Sequence Generates Low Nanomolar aVb3/aVb5 Integrin Dual Binders. (Articolo in rivista) (Prodotto della ricerca)
• Synthesis, cannabinoid receptor affinity, and molecular modeling studies of substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Substitution of the Arginine/Leucine Residues in Apidaecin Ib with Peptoid Residues: Effect on Antimicrobial Activity, Cellular Uptake, and Proteolytic Degradation (Articolo in rivista) (Prodotto della ricerca)
• Rational design, synthesis, and pharmacological properties of new 1,8-naphthyridin-2(1H)-on-3-carboxamide derivatives as highly selective cannabinoid-2 receptor agonists (Articolo in rivista) (Prodotto della ricerca)
• Investigations on the 4-quinolone-3-carboxylic acid motif. 3. Synthesis, structure-affinity relationships, and pharmacological characterization of 6-substituted 4-quinolone-3-carboxamides as highly selective cannabinoid-2 receptor ligands. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Palmitoyl Derivatives of GpMBP Epitopes: T-Cell Response and Peptidases Susceptibility (Articolo in rivista) (Prodotto della ricerca)
• Platinum Complexes Can Inhibit Matrix Metalloproteinase Activity: Platinum- diethyl[(methylsulfinyl)methyl]phosphonate Complexes as Inhibitors of Matrix Metalloproteinases 2, 3, 9 and 12 (Articolo in rivista) (Prodotto della ricerca)
• Small-molecule targeting of heat shock protein 90 chaperone function: Rational identification of a new anticancer lead (Articolo in rivista) (Prodotto della ricerca)
• Activity of rat cytosolic thioredoxin reductase is strongly decreased by trans-[bis(2-amino-5- methylthiazole)tetrachlororuthenate(III)]: first report of relevant thioredoxin reductase inhibition for a ruthenium compound. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Extra Binding Region Induced by Non-Zinc Chelating Inhibitors into the S-1 ' Subsite of Matrix Metalloproteinase 8 (MMP-8) (Articolo in rivista) (Prodotto della ricerca)
• Structural Insight into Peroxisome Proliferator-Activated Receptor ³ Binding of Two Ureidofibrate-Like Enantiomers by Molecular Dynamics, Cofactor Interaction Analysis, and Site-Directed Mutagenesis (Articolo in rivista) (Prodotto della ricerca)
• Probing Torpedo californica acetylcholinesterase catalytic gorge with two novel bis-functional galanthamine derivatives. (Articolo in rivista) (Prodotto della ricerca)
• Crystal structures of the vitamin D nuclear receptor liganded with the vitamin D side chain analogues calcipotriol and seocalcitol, receptor agonists of clinical importance. Insights into a structural basis for the switching of calcipotriol to a receptor (Articolo in rivista) (Prodotto della ricerca)
• A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors. (Articolo in rivista) (Prodotto della ricerca)
• Indolyl aryl sulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: role of two halogen atoms at the indole ring in developing new analogues with improved antiviral activity. (Articolo in rivista) (Prodotto della ricerca)
• Dihydro-alkylthio-benzyl-oxopyrimidines as inhibitors of reverse transcriptase: synthesis and rationalization of the biological data on both wild-type enzyme and relevant clinical mutants. (Articolo in rivista) (Prodotto della ricerca)
• Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Indolylarylsulfones as HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: New Cyclic Substituents at Indole-2-carboxamide. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Synthesis of stable and Potent d/m Optical Peptides: Analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]OH by Ring-Closing Metathesis (Articolo in rivista) (Prodotto della ricerca)
• Design, synthesis, and preliminary pharmacological evaluation of new quinoline derivatives as nicotinic ligands. (Articolo in rivista) (Prodotto della ricerca)
• Activity of rat cytosolic thioredoxin reductase is strongly decreased by (Articolo in rivista) (Prodotto della ricerca)
• Ester-based precursors to increase the bioavailability of quercetin (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Phenyl-imidazo[1,2-a]pyridine compounds containing hydrophilic groups as potent and selective ligands for peripheral benzodiazepine receptors: synthesis, binding affinity and electrophysiological studies (Articolo in rivista) (Prodotto della ricerca)
• Mixed steroidal 1,2,4,5-tetraoxanes: antimalarial and antimycobacterial activity (Articolo in rivista) (Prodotto della ricerca)
• Homology modelling studies on human galactose-1-phosphate uridylyltransferase and on its galactosemia-related mutant Q188R provide an explanation of molecular effects of the mutation on homo- and heterodimers. (Articolo in rivista) (Prodotto della ricerca)
• Endomorphin-1 Analogues Containing -Proline Are -Opioid Receptor Agonists and Display Enhanced Enzymatic Hydrolysis Resistance (Articolo in rivista) (Prodotto della ricerca)
• Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• 1-methil-3H-pyrazolo[1-2-a]benzo[1-2-3-4]tetrazin-3-ones, design synthesis and biological activity of new antitumoral agents (Articolo in rivista) (Prodotto della ricerca)
• Polymer-drug conjugates for combination anticancer therapy: investigating the mechanism of action (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Synthesis, binding, and modeling studies of new cytisine derivatives, as ligands for neuronal nicotinic acetylcholine receptor subtypes. (Articolo in rivista) (Prodotto della ricerca)
• Unichiral 2-(2 '-Pyrrolidinyl)-1,4-benzodioxanes: the 2R,2 ' S Diastereomer of the N-Methyl-7-hydroxy Analogue Is a Potent alpha 4 beta 2-and alpha 6 beta 2-Nicotinic Acetylcholine Receptor Partial Agonist (Articolo in rivista) (Prodotto della ricerca)
• Targeted biocompatible nanoparticles for the delivery of (-)-epigallocatechin 3-gallate to prostate cancer cells. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Structure-activity relationship in 4-aminoquinoline antiplasmodials. The role of the group at the 7-position (Articolo in rivista) (Prodotto della ricerca)
• Highly Selective Fluorescent Analogue of the Potent d-Opioid Receptor Antagonist Dmt-Tic (Articolo in rivista) (Prodotto della ricerca)
• Novel hypotensive agents from Verbesina caracasana. 8. Synthesis and pharmacology of (3,4-dimethoxycinnamoyl)-N1-agmatine and synthetic analogues (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• NMR structural studies of the supramolecular adducts between a liver cytosolic bile acid binding protein and Gd(III)-chelates bearing bile acids residues: molecular determinants of the binding of hepatospecific MRI contrast agent (Articolo in rivista) (Prodotto della ricerca)
• Solution structure of the supramolecular adduct between a liver cytosolic bile acid binding protein and a bile acid-based gadolinium(III)-chelate, a potential hepatospecific magnetic resonance imaging contrast agent. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Tricyclic pyrazoles. 4. Synthesis and biological evaluation of analogues of the robust and selective CB2 cannabinoid ligand 1-(2',4'-dichlorophenyl)-6-methyl-N-piperidin-1-yl-1,4-dihydroindeno[1,2-c]pyrazo le-3-carboxamide (Articolo in rivista) (Prodotto della ricerca)
• New Insight into the Central Benzodiazepine Receptor-Ligand Interactions: Design, Synthesis, Biological Evaluation, and Molecular Modeling of 3-Substituted 6-Phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and Related Compounds (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Cisplatinum and Transplatinum Complexes with Benzyliminoether Ligands. Synthesis, Characterization, Structure-Activity Relationships, in Vitro and in Vivo Antitumor Efficacy (Articolo in rivista) (Prodotto della ricerca)
• Synthesis and biological evaluation of 2 '-methyl taxoids derived from baccatin III and 14 beta-OH-baccatin III 1,14-carbonate (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Thiocamptothecin (Articolo in rivista) (Prodotto della ricerca)
• Parallel Synthesis, Evaluation, and Preliminary Structure-Activity Relationship of 2,5-Diamino-1,4-benzoquinones as a Novel Class of Bivalent Anti-Prion Compound (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Indolylarylsulfones Bearing Natural and Unnatural Amino Acids. Discovery of Potent Inhibitors of HIV-1 Non-Nucleoside Wild Type and Resistant Mutant Strains Reverse Transcriptase and Coxsackie B4 Virus (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Mechanisms of cytotoxicity of selected organogold(III) compounds (Articolo in rivista) (Prodotto della ricerca)
• Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• A New Class of Antitumor trans-Amine-Amidine-Pt(II) Cationic Complexes: Influence of Chemical Structure and Solvent on in Vitro and in Vivo Tumor Cell Proliferation (Articolo in rivista) (Prodotto della ricerca)
• New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists able ti up regulate the mitochondrial carnitine shuttle system gene expression. (Articolo in rivista) (Prodotto della ricerca)
• 2-(Alkyl/aryl)amino-6-benzylpyrimidin-4(3H)-ones as inhibitors of wild-type and mutant HIV-1: enantioselectivity studies (Articolo in rivista) (Prodotto della ricerca)
• New N-arachidonoylserotonin analogues with potential 'dual' mechanism of action against pain. (Articolo in rivista) (Prodotto della ricerca)
• Efficient Transfection of DNA by Liposomes Formulated with Cationic Gemini Amphiphiles (Articolo in rivista) (Prodotto della ricerca)
• Characterization of a Designed Vascular Endothelial Growth Factor Receptor Antagonist Helical Peptide with Antiangiogenic Activity in Vivo (Articolo in rivista) (Prodotto della ricerca)
• 1,4-Dioxane, a Suitable Scaffold for the Development of Novel M-3 Muscarinic Receptor Antagonists (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Indole-Derived Psammaplin A Analogues as Epigenetic Modulators with Multiple Inhibitory Activities. (Articolo in rivista) (Prodotto della ricerca)
• Discovery of Salermide-Related Sirtuin Inhibitors: Binding Mode Studies and Antiproliferative Effects in Cancer Cells Including Cancer Stem Cells (Articolo in rivista) (Prodotto della ricerca)
• New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors (Articolo in rivista) (Prodotto della ricerca)
• Oxyhomologs of anandamide and related endolipids. Chemoselective synthesis and biological activity (Articolo in rivista) (Prodotto della ricerca)
• Modulation of cell differentiation, proliferation, and tumor growth by dihydrobenzyloxopyrimidine non-nucleoside reverse transcriptase inhibitors (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Solution Structure of Mouse Cripto CFC Domain and Its Inactive Variant Trp107Ala. (Articolo in rivista) (Prodotto della ricerca)
• The taming of capsaicin. Reversal of the vanilloid activity of N-acylvanillamines by aromatic iodination (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Carbonic anhydrase inhibitors: bioreductive nitro-containing sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II. (Articolo in rivista) (Prodotto della ricerca)
• Carbonic Anhydrase Inhibitors. Comparison of Aliphatic Sulfamate/Bis-sulfamate Adducts with Isozymes II and IX as a Platform for Designing Tight-Binding, More Isoform-Selective Inhibitors (Articolo in rivista) (Prodotto della ricerca)
• Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Synthesis and Biological Evaluation (in Vitro and in Vivo) of Cyclic Arginine-Glycine-Aspartate (RGD) Peptidomimetic-Paclitaxel Conjugates Targeting Integrin alphaVbeta3 (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues: Part 2 (Articolo in rivista) (Prodotto della ricerca)
• Novel nonsubstrate inhibitors of human thymidine phosphorylase, a potential target for tumor-dependent angiogenesis. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Molecular modeling and synthesis of inhibitors of herpes simplex virus type 1 uracil-DNA glycosylase (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Synthesis, properties, and pharmacokinetic studies of N2-phenylguanine derivatives as inhibitors of herpes simplex virus thymidine kinases. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Pyrrolobenzoxazepinone derivatives as non-nucleoside HIV-1 RT inhibitors: Further structure-activity relationship studies and identification of more potent broad-spectrum HIV-1 RT inhibitors with antiviral activity (Articolo in rivista) (Prodotto della ricerca)
• BENZO[C]QUINOLIZIN-3-ONES: A NOVEL CLASS OF POTENT AND SELECTIVE NONSTEROIDAL INHIBITORS OF HUMAN STEROID 5?-REDUCTASE 1 (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Novel Mixed-Ligand Copper(I) Complexes: Role of Diimine Ligands on Cytotoxicity and Genotoxicity (Articolo in rivista) (Prodotto della ricerca)
• Cationic [99mTcIII(DIARS)2(SR)2]+ complexes as potential myocardial perfusion imaging agents (DIARS = o-phenylenebis(dimethylarsine); SR- = thiolate) (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Design, synthesis, and evaluation of hydroxamic acid derivatives as promising agents for the management of Chagas disease (Articolo in rivista) (Prodotto della ricerca)
• Oligonucleotide Analogues as Modulators of the Expression and Function of Noncoding RNAs (ncRNAs): Emerging Therapeutics Applications. (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Conformational Modifications of gB from Herpes Simplex Virus Type 1 Analyzed by Synthetic Peptides (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Synthesis and Biological Evaluation of Direct Thrombin Inhibitors Bearing 4-(Piperidin-1-yl)pyridine at the P1 Position with Potent Anticoagulant Activity (Articolo in rivista) (Prodotto della ricerca)
• QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS OF N-2-PHENYLGUANINES AS INHIBITORS OF HERPES-SIMPLEX VIRUS THYMIDINE KINASES (Articolo in rivista) (Prodotto della ricerca)
• STRUCTURE-ACTIVITY-RELATIONSHIPS OF N-2-SUBSTITUTED GUANINES AS INHIBITORS OF HSV1 AND HSV2 THYMIDINE KINASES (Articolo in rivista) (Prodotto della ricerca)
• 1,3,4-Oxadiazole-Containing Histone Deacetylase Inhibitors: Anticancer Activities in Cancer Cells (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Exploring the Role of 2-Chloro-6-fluoro Substitution in 2-Alkylthio-6-benzyl-5-alkylpyrimidin-4(3H)-ones: Effects in HIV-1-Infected Cells and in HIV-1 Reverse Transcriptase Enzymes (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• N-2 PHENYLDEOXYGUANOSINE A NOVEL SELECTIVE INHIBITOR OF HERPES SIMPLEX THYMIDINE KINASE (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Folic Acid-Conjugated Europium Complexes as Luminescent Probes for Selective Targeting of Cancer Cells (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• In Vitro and in Vivo Anticancer Activity of Copper(I) Complexes with Homoscorpionate Tridentate Tris(pyrazolyl)borate and Auxiliary Monodentate Phosphine Ligands (Articolo in rivista) (Prodotto della ricerca)
• Pan-Histone Demethylase Inhibitors Simultaneously Targeting Jumonji C and Lysine-Specific Demethylases Display High Anticancer Activities (Articolo in rivista) (Prodotto della ricerca)
• A New Avenue toward Androgen Receptor Pan-antagonists: C2 Sterically Hindered Substitution of Hydroxy-propanamides (Articolo in rivista) (Prodotto della ricerca)
• Indolylarylsulfones Carrying a Heterocyclic Tail as Very Potent and Broad Spectrum HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Novel [Tc-99m(III)(PS)(2)(Ln)] Mixed-Ligand Compounds (PS = Phosphinothiolate; L = Dithiocarbamate) Useful in Design and Development of Tc-III-Based Agents: Synthesis, in Vitro, and ex Vivo Biodistribution Studies (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• How a beta-D-Glucoside Side Chain Enhances Binding Affinity to Thrombin of Inhibitors Bearing 2-Chlorothiophene as P1 Moiety: Crystallography, Fragment Deconstruction Study, and Evaluation of Antithrombotic Properties (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• New Pyrrole Derivatives with Potent Tubulin Polymerization Inhibiting Activity As Anticancer Agents Including Hedgehog-Dependent Cancer (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Multitarget Drug Design Strategy: Quinone-Tacrine Hybrids Designed To Block Amyloid-beta Aggregation and To Exert Anticholinesterase and Antioxidant Effects (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)
• Combining X-ray crystallography and molecular modeling toward the optimization of pyrazolo[3,4-d ]pyrimidines as potent c-Src inhibitors active in vivo against neuroblastoma (Articolo in rivista) (http://www.cnr.it/ontology/cnr/individuo/prodotto/TIPO1101)