http://www.cnr.it/ontology/cnr/individuo/prodotto/ID9990
Unorthodox view of the functioning of a GABA(A) synapse (Articolo in rivista)
- Type
- Label
- Unorthodox view of the functioning of a GABA(A) synapse (Articolo in rivista) (literal)
- Anno
- 2002-01-01T00:00:00+01:00 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Cupello A., Rapallino M.V. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Titolo
- Unorthodox view of the functioning of a GABA(A) synapse (literal)
- Abstract
- 1. Studies about the permeation of labelled chloride and GABA across
single plasma membranes microdissected from vestibular Deiters' neurons
have yielded two unexpected results: (a) intracellular GABA stimulates
chloride permeation in an asymmetric fashion (efflux being favoured); (b)
under certain conditions GABA permeates by a diffusion mechanism in the
out-->in direction across these plasma membranes. 2. These two main
results have been obtained over many years together with a host of other
indications about the fine mechanism of these events. Thus, a picture has
emerged of their physiological meaning within the context of the
functioning of the GABAA synapses between the Purkinje cells and the
Deiters' neurons. 3. In short, it is proposed that at these synapses GABA
accumulates into the postsynaptic neuron after its release and activation
of the postsynaptic receptors. GABA accumulated in the Deiters' neurons is
involved in the process of chloride extrusion to build an inward directed
electrochemical gradient for chloride.
(literal)
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- Autore CNR
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