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Role of creatine and phosphocreatine in neuronal protection from anoxic and ischemic damage (Articolo in rivista)
- Type
- Label
- Role of creatine and phosphocreatine in neuronal protection from anoxic and ischemic damage (Articolo in rivista) (literal)
- Anno
- 2002-01-01T00:00:00+01:00 (literal)
- Alternative label
Balestrino M., Lensman M., Parodi M., Perasso L., Rebaudo R., Melani R., Polenov S., Cupello A. (2002)
Role of creatine and phosphocreatine in neuronal protection from anoxic and ischemic damage
in Amino acids (Wien, Print)
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- Balestrino M., Lensman M., Parodi M., Perasso L., Rebaudo R., Melani R., Polenov S., Cupello A. (literal)
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- ISI Web of Science (WOS) (literal)
- Titolo
- Role of creatine and phosphocreatine in neuronal protection from anoxic and ischemic damage (literal)
- Abstract
- Phosphocreatine can to some extent compensate for the lack of ATP
synthesis that is caused in the brain by deprivation of oxygen or glucose.
Treatment of in vitro rat hippocampal slices with creatine increases the
neuronal store of phosphocreatine. In this way it increases the resistance
of the tissue to anoxic or ischemic damage. In in vitro brain slices
pretreatment with creatine delays anoxic depolarization (AD) and prevents
the irreversible loss of evoked potentials that is caused by transient
anoxia, although it seems so far not to be active against milder, not AD-
mediated, damage. Although creatine crosses poorly the blood-brain
barrier, its administration in vivo at high doses through the
intracerebroventricular or the intraperitoneal way causes an increase of
cerebral phosphocreatine that has been shown to be of therapeutic value in
vitro. Accordingly, preliminary data show that creatine pretreatment
decreases ischemic damage in vivo.
(literal)
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