http://www.cnr.it/ontology/cnr/individuo/prodotto/ID9958
On the molecular structure of human neuroserpin polymers (Articolo in rivista)
- Type
- Label
- On the molecular structure of human neuroserpin polymers (Articolo in rivista) (literal)
- Anno
- 2012-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1002/prot.23197 (literal)
- Alternative label
Santangelo MG; Noto R; Levantino M; Cupane A; Ricagno S, Pezzullo M, Bolognesi M, Mangione MR, Martorana V, Manno M (2012)
On the molecular structure of human neuroserpin polymers
in Proteins (Print); WILEY-BLACKWELL, MALDEN 02148,MA (Stati Uniti d'America)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Santangelo MG; Noto R; Levantino M; Cupane A; Ricagno S, Pezzullo M, Bolognesi M, Mangione MR, Martorana V, Manno M (literal)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
- http://onlinelibrary.wiley.com/doi/10.1002/prot.23197/abstract?systemMessage=Wiley+Online+Library+will+be+disrupted+on+17+December+from+at+23%3A00+GMT+%2818%3A00+EST%29+for+essential+maintenance+for+approximately+one+hour (literal)
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Natl Res Council Italy, Inst Biophys, I-90146 Palermo, Italy; Univ Palermo, Dept Phys, I-90123 Palermo, Italy; Univ Milan, Inst Biophys CNR, Dept Biomol Sci & Biotechnol, Milan, Italy; Univ Milan, CIMAINA, Milan, Italy (literal)
- Titolo
- On the molecular structure of human neuroserpin polymers (literal)
- Abstract
- The polymerization of serpins is at the root of a large class of diseases; the molecular structure of serpin polymers has been recently debated. In this work, we study the polymerization kinetics of human neuroserpin by Fourier Transform Infra Red spectroscopy and by time-lapse Size Exclusion Chromatography. First, we show that two distinct neuroserpin polymers, formed at 45 and 85°C, display the same isosbestic points in the Amide I2 band, and therefore share common secondary structure features. We also find a concentration independent polymerization rate at 45°C suggesting that the polymerization rate-limiting step is the formation of an activated monomeric species. The polymer structures are consistent with a model that predicts the bare insertion of portions of the reactive center loop into the A ²-sheet of neighboring serpin molecule, although with different extents at 45 and 85°C (literal)
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