http://www.cnr.it/ontology/cnr/individuo/prodotto/ID9943
Polyaspartamide-graft-polymethacrylate nanoparticles for doxorubicin delivery (Articolo in rivista)
- Type
- Label
- Polyaspartamide-graft-polymethacrylate nanoparticles for doxorubicin delivery (Articolo in rivista) (literal)
- Anno
- 2011-01-01T00:00:00+01:00 (literal)
- Alternative label
Licciardi M, Cavallaro G, Di Stefano M, Fiorica C, Giammona G (2011)
Polyaspartamide-graft-polymethacrylate nanoparticles for doxorubicin delivery
in Macromolecular bioscience (Print)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Licciardi M, Cavallaro G, Di Stefano M, Fiorica C, Giammona G (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- IBF-CNR e UniPa (literal)
- Titolo
- Polyaspartamide-graft-polymethacrylate nanoparticles for doxorubicin delivery (literal)
- Abstract
- A new PHEA-IB-PMANa(+) copolymer has been synthesized and its pH-induced self-assembly has been investigated in an aqueous medium. PHEA-IB-PMANa+ formed nanoparticles with diameters from 25 to 50 nm upon protonation of the carboxylic acid moieties dislocated along the grafted polymethacrylate sodium salt side chains. The physico-chemical characterization of the nanoparticles was performed using light scattering, zeta-potential measurements, SEM, and AFM. Doxorubicin-loaded nanoparticles were prepared and drug release profiles were evaluated under conditions mimicking physiological media. A biological characterization was carried out by testing the cytotoxicity on Caco-2 cells, and cellular uptake on mouse monocyte macrophage (J774 A.1) and Caco-2 cells (literal)
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- Autore CNR
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