http://www.cnr.it/ontology/cnr/individuo/prodotto/ID9808
Polysaccharide/polyaminoacid composite scaffolds for modified DNA release (Articolo in rivista)
- Type
- Label
- Polysaccharide/polyaminoacid composite scaffolds for modified DNA release (Articolo in rivista) (literal)
- Anno
- 2009-01-01T00:00:00+01:00 (literal)
- Alternative label
Pitarresi, G., Calabrese, R., Palumbo, F.S., Licciardi, M., Giammona, G (2009)
Polysaccharide/polyaminoacid composite scaffolds for modified DNA release
in International journal of pharmaceutics (Print)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Pitarresi, G., Calabrese, R., Palumbo, F.S., Licciardi, M., Giammona, G (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Titolo
- Polysaccharide/polyaminoacid composite scaffolds for modified DNA release (literal)
- Abstract
- In this work composite polymeric films or sponges, based on hyaluronic acid (HA) covalently crosslinked with alpha,beta-poly(N-2-hydroxyethyl)(2-aminoethylcarbamate)-D,L-aspartamide (PE), have been prepared and characterized as local gene delivery systems. In particular, HA/PE scaffolds have been loaded with PE/DNA interpolyelectrolyte complexes, employing PE as a macromolecular crosslinker for HA and as a non-viral vector for DNA. In vitro studies showed that HA/PE films and sponges have high compatibility with human dermal fibroblasts and they give a sustained DNA release, whose trend can be easily tailored by varying the crosslinking ratio between HA and PE. Electrophoresis analysis and transfection studies on B16-F10 cells revealed that DNA is released as a complex with PE and it retains its bioactivity. (literal)
- Prodotto di
- Autore CNR
Incoming links:
- Prodotto
- Autore CNR di
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi