Polysaccharide/polyaminoacid composite scaffolds for modified DNA release (Articolo in rivista)

Type
Label
  • Polysaccharide/polyaminoacid composite scaffolds for modified DNA release (Articolo in rivista) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Alternative label
  • Pitarresi, G., Calabrese, R., Palumbo, F.S., Licciardi, M., Giammona, G (2009)
    Polysaccharide/polyaminoacid composite scaffolds for modified DNA release
    in International journal of pharmaceutics (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Pitarresi, G., Calabrese, R., Palumbo, F.S., Licciardi, M., Giammona, G (literal)
Pagina inizio
  • 7 (literal)
Pagina fine
  • 14 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 382 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Titolo
  • Polysaccharide/polyaminoacid composite scaffolds for modified DNA release (literal)
Abstract
  • In this work composite polymeric films or sponges, based on hyaluronic acid (HA) covalently crosslinked with alpha,beta-poly(N-2-hydroxyethyl)(2-aminoethylcarbamate)-D,L-aspartamide (PE), have been prepared and characterized as local gene delivery systems. In particular, HA/PE scaffolds have been loaded with PE/DNA interpolyelectrolyte complexes, employing PE as a macromolecular crosslinker for HA and as a non-viral vector for DNA. In vitro studies showed that HA/PE films and sponges have high compatibility with human dermal fibroblasts and they give a sustained DNA release, whose trend can be easily tailored by varying the crosslinking ratio between HA and PE. Electrophoresis analysis and transfection studies on B16-F10 cells revealed that DNA is released as a complex with PE and it retains its bioactivity. (literal)
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