Nanoporous surfaces as harvesting agents for mass spectrometric analysis of peptides in human plasma (Articolo in rivista)

Type
Label
  • Nanoporous surfaces as harvesting agents for mass spectrometric analysis of peptides in human plasma (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Alternative label
  • Gaspari, M; Cheng, MMC; Terracciano, R; Liu, XW; Nijdam, AJ; Vaccari, L; di Fabrizio, E; Petricoin, EF; Liotta, LA; Cuda, G; Venuta, S; Ferrari, M (2006)
    Nanoporous surfaces as harvesting agents for mass spectrometric analysis of peptides in human plasma
    in Journal of proteome research (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Gaspari, M; Cheng, MMC; Terracciano, R; Liu, XW; Nijdam, AJ; Vaccari, L; di Fabrizio, E; Petricoin, EF; Liotta, LA; Cuda, G; Venuta, S; Ferrari, M (literal)
Pagina inizio
  • 1261 (literal)
Pagina fine
  • 1266 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 5 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Magna Groecia Univ, Dept Clin & Expt Med, I-88100 Catanzaro, Italy; Ohio State Univ, Div Hematol & Oncol, Columbus, OH 43210 USA; TASC, INFM, CNR, I-34012 Trieste, Italy; George Mason Univ, Ctr Appl Proteom & Mol Med, Manassas, VA 20110 USA (literal)
Titolo
  • Nanoporous surfaces as harvesting agents for mass spectrometric analysis of peptides in human plasma (literal)
Abstract
  • Silica-based nanoporous surfaces have been developed in order to capture low molecular weight peptides from human plasma. Harvested peptides were subjected to mass spectrometric analysis by using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) as a means of detecting and assessing the bound molecules. Peptide profiles consisting of about 70 peaks in the range 800-10 000 m/z were generated. The method could allow detection of small peptides at ng/mL concentration levels, either in standard solutions or in plasma. The same molecular cutoff effect was observed for mixtures of standard proteins and peptides incubated with silicon-based nanoporous surfaces. (literal)
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