Functional evidence for presynaptic P2X7 receptors in adult rat cerebrocortical nerve terminals (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Functional evidence for presynaptic P2X7 receptors in adult rat cerebrocortical nerve terminals (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.febslet.2008.10.041 (literal)

Alternative label

• Susanna Alloisio(a); Chiara Cervetto(b); Mario Passalacqua(c); Raffaella Barbieri(a); Guido Maura(b,d,e); Mario Nobile(a); Manuela Marcoli(b) (2008)
  Functional evidence for presynaptic P2X7 receptors in adult rat cerebrocortical nerve terminals
  in FEBS letters (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Susanna Alloisio(a); Chiara Cervetto(b); Mario Passalacqua(c); Raffaella Barbieri(a); Guido Maura(b,d,e); Mario Nobile(a); Manuela Marcoli(b) (literal)

Pagina inizio

• 3948 (literal)

Pagina fine

• 3953 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 582 (literal)

Rivista

• FEBS letters (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 28 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• a Institute of Biophysics, CNR, Via De Marini, 6 - 16149 Genoa, Italy b Section of Pharmacology and Toxicology University of Genoa, Italy c Section of Biochemistry, Department of Experimental Medicine, University of Genoa, Italy d Center of Excellence for Biomedical Research, University of Genoa, Italy e National Institute of Neuroscience INN, Italy (literal)

Titolo

• Functional evidence for presynaptic P2X7 receptors in adult rat cerebrocortical nerve terminals (literal)

Abstract

• The presynaptic P2X7 receptor (P2X7R) plays an important role in the modulation of transmitter release. We recently demonstrated that, in nerve terminals of the adult rat cerebral cortex, P2X7R activation induced Ca2+-dependent vesicular glutamate release and significant Ca2+-independent glutamate efflux through the P2X7R itself. In the present study, we investigated the effect of the new selective P2X(7)R competitive antagonist 3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methyl pyridine (A-438079) on cerebrocortical terminal intracellular calcium (intrasynaptosomal calcium concentration;[Ca2+](i) signals and glutamate release, and evaluated whether P2X7R immunoreactivity was consistent with these functional tests. A-438079 inhibited functional responses. P2X7R immunoreactivity was found in about 45% of cerebrocortical terminals, including glutamatergic and non-glutamatergic terminals. This percentage was similar to that of synaptosomes showing P2X7R-mediated [Ca2+]i signals. These findings provide compelling evidence of functional presynaptic P2X7R in cortical nerve terminals. (literal)

Prodotto di

• Processi di membrana nella comunicazione intra- ed inter-cellulare (MD.P01.001.001) (Modulo)
• Istituto di biofisica (IBF) (Istituto)

Autore CNR

• RAFFAELLA BARBIERI (Unità di personale esterno)
• MARIO NOBILE (Unità di personale interno)
• SUSANNA ALLOISIO (Unità di personale esterno)

Insieme di parole chiave

• Parole chiave di "Functional evidence for presynaptic P2X7 receptors in adult rat cerebrocortical nerve terminals" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di biofisica (IBF) (Istituto)
• Processi di membrana nella comunicazione intra- ed inter-cellulare (MD.P01.001.001) (Modulo)

Autore CNR di

• MARIO NOBILE (Unità di personale interno)
• SUSANNA ALLOISIO (Unità di personale esterno)
• RAFFAELLA BARBIERI (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• FEBS letters (Rivista)

Insieme di parole chiave di

• Parole chiave di "Functional evidence for presynaptic P2X7 receptors in adult rat cerebrocortical nerve terminals" (Insieme di parole chiave)