Transmembrane Domain Length of Viral Potassium Ion Channels is a Signal for Mitochondria Targeting (Articolo in rivista)

Type
Label
  • Transmembrane Domain Length of Viral Potassium Ion Channels is a Signal for Mitochondria Targeting (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1073/pnas.0805709105 (literal)
Alternative label
  • Balss J.; Papatheodorou P.; Mehmel M.; Baumeister D.; Hertel B.; Delaroque N.; Chatelain F.C.; Minor D.L. Jr; Van Etten J.L.; Rassow J.; Moroni A.; Thiel G.. (2008)
    Transmembrane Domain Length of Viral Potassium Ion Channels is a Signal for Mitochondria Targeting
    in Proceedings of the National Academy of Sciences of the United States of America
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Balss J.; Papatheodorou P.; Mehmel M.; Baumeister D.; Hertel B.; Delaroque N.; Chatelain F.C.; Minor D.L. Jr; Van Etten J.L.; Rassow J.; Moroni A.; Thiel G.. (literal)
Pagina inizio
  • 12313 (literal)
Pagina fine
  • 12318 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 105 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 34 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Balss J., Mehmel M., Baumeister D., Hertel B., Thiel G.: Institute of Botany, Technische Universita¨ t Darmstadt, D-64287 Darmstadt, Germany; Papatheodorou P., Rassow J.:+Institute for Physiological Chemistry, Ruhr-Universita¨ t Bochum, D-44780 Bochum, Germany; Nicolas Delaroque: Max Planck Institute of Chemical Ecology, D-07745 Jena, Germany; Franck C. Chatelain, Daniel L. Minor, Jr.: Cardiovascular Research Institute, University of California, San Francisco, CA 94158-2330; James L. Van Etten: Department of Plant Pathology and Nebraska Center for Virology, University of Nebraska, Lincoln, NE 68583-0722; Anna Moroni: Department of Biology and Consiglio Nazionale delle Ricerche, Istituto di Biofisica-Mi, Universita` degli Studi, 20133 Milano, Italy (literal)
Titolo
  • Transmembrane Domain Length of Viral Potassium Ion Channels is a Signal for Mitochondria Targeting (literal)
Abstract
  • K(+) channels operate in the plasma membrane and in membranes of organelles including mitochondria. The mechanisms and topogenic information for their differential synthesis and targeting is unknown. This article describes 2 similar viral K(+) channels that are differentially sorted; one protein (Kesv) is imported by the Tom complex into the mitochondria, the other (Kcv) to the plasma membrane. By creating chimeras we discovered that mitochondrial sorting of Kesv depends on a hierarchical combination of N- and C-terminal signals. Crucial is the length of the second transmembrane domain; extending its C terminus by > or = 2 hydrophobic amino acids redirects Kesv from the mitochondrial to the plasma membrane. Activity of Kesv in the plasma membrane is detected electrically or by yeast rescue assays only after this shift in sorting. Hence only minor structural alterations in a transmembrane domain are sufficient to switch sorting of a K(+) channel between the plasma membrane and mitochondria. (literal)
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