Botulinum neurotoxin E (BoNT/E) reduces CA1 neuron loss and granule cell dispersion, with no effects on chronic seizures, in a mause model of temporal lobe epilepsy. (Articolo in rivista)

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  • Botulinum neurotoxin E (BoNT/E) reduces CA1 neuron loss and granule cell dispersion, with no effects on chronic seizures, in a mause model of temporal lobe epilepsy. (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.expneurol.2007.11.012 (literal)
Alternative label
  • Antonucci F.;Di Garbo A.; Novelli E.; Manno I.; Sartucci F.; Bozzi Y.; Caleo M. (2008)
    Botulinum neurotoxin E (BoNT/E) reduces CA1 neuron loss and granule cell dispersion, with no effects on chronic seizures, in a mause model of temporal lobe epilepsy.
    in Experimental neurology; S. Gilman, Ann Arbor, MI (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Antonucci F.;Di Garbo A.; Novelli E.; Manno I.; Sartucci F.; Bozzi Y.; Caleo M. (literal)
Pagina inizio
  • 388 (literal)
Pagina fine
  • 401 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.sciencedirect.com/science/article/pii/S0014488607004268 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 210 (literal)
Rivista
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  • 14 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Flavia Antonucci, CNR- Istituto di Neuroscienze, via G. Moruzzi 1, 56124 Pisa Angelo Di Garbo,CNR- Istituto di Biofisica, via G. Moruzzi 1, 56124 Pisa Elena Novelli, Fondazione Bietti, Roma Ilaria Manno, Scuola Normale Superiore, Pisa Ferdinando Sartucci, Dipartimento di Neuroscienze, Facolta' di Medicina e Chirurgia, Universita' di Pisa Yuri Bozzi, CNR- Istituto di Neuroscienze, via G. Moruzzi 1, 56124 Pisa Matteo Caleo, CNR- Istituto di Neuroscienze, via G. Moruzzi 1, 56124 Pisa (literal)
Titolo
  • Botulinum neurotoxin E (BoNT/E) reduces CA1 neuron loss and granule cell dispersion, with no effects on chronic seizures, in a mause model of temporal lobe epilepsy. (literal)
Abstract
  • Mesial temporal lobe epilepsy (MTLE) is often the result of an early insult that induces a reorganization in hippocampal circuitry leading, after a latent period, to chronic epilepsy. Hippocampal rearrangements during the latent phase include neuronal loss, axonal and dendritic plasticity, neurogenesis, and cell repositioning, but the role of these changes in epilepsy development is unclear. Here we have tested whether administration of the synaptic blocker botulinum neurotoxin E (BoNT/E) interferes with development of spontaneous seizures and histopathological changes following an episode of status epilepticus (SE). SE was induced by unilateral intrahippocampal injection of kainic acid in mice and BoNT/E was delivered to the same hippocampus 3 h later. We found that treatment with BoNT/E prolonged the duration of the latent period but did not block the occurrence of spontaneous seizures. At the histopathological level, BoNT/E reduced loss of CA1 pyramidal neurons and dispersion of dentate granule cells. Downregulation of reelin expression along the hippocampal fissure was also suppressed by BoNT/E treatment. Our findings indicate that administration of BoNT/E after SE inhibits specific morphological changes in hippocampal circuitry but not the development of spontaneous seizures. This indicates a dissociation between certain anatomical modifications and establishment of chronic epilepsy in MTLE. (literal)
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