Electrokinetics of smallest K+ channel: Open state V-sensitivity and inhibition by K+ driving force. (Articolo in rivista)

Type
Label
  • Electrokinetics of smallest K+ channel: Open state V-sensitivity and inhibition by K+ driving force. (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Alternative label
  • Gazzarrini S., Abenavoli A., Gradmann D., Thiel G., Moroni A. (2007)
    Electrokinetics of smallest K+ channel: Open state V-sensitivity and inhibition by K+ driving force.
    in The journal of membrane biology (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Gazzarrini S., Abenavoli A., Gradmann D., Thiel G., Moroni A. (literal)
Pagina inizio
  • 9 (literal)
Pagina fine
  • 17 (literal)
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  • 214 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Biology and IBF-CNR, Università degli Studi di Milano, Via Celoria 26, 20133, Milan, Italy; A.-v.-Haller-Institut der Universität, Untere Karspüle 2, 37073, Göttingen, Germany; Botanisches Institut, Technischen Universität, Schnittspahnstr. 3, 64287, Darmstadt, Germany (literal)
Titolo
  • Electrokinetics of smallest K+ channel: Open state V-sensitivity and inhibition by K+ driving force. (literal)
Abstract
  • Kcv, isolated from a Chlorella virus, is the smallest known K+ channel. When Kcv is expressed in Xenopus oocytes and exposed to 50 mM: [K+](o), its open-state current-voltage relationship (I-V) has the shape of a \"tilted S\" between -200 and +120 mV. Details of this shape depend on the conditioning voltage (V (c)) immediately before an I-V recording. Unexpectedly, the I-V relationships, recorded in different [K+](o), do intersect. These characteristics are numerically described here by fits of a kinetic model to the experimental data. In this model, the V (c) sensitivity of I-V is mainly assigned to an affinity increase of external K+ association at more positive voltages. The general, tilted-S shape as well as the unexpected intersections of the I-V relationships are kinetically described by a decrease of the cord conductance by the electrochemical driving force for K+ in either direction, like in fast V-dependent blocking by competing ions. (literal)
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