Staphylococcus aureus bi-component g-hemolysins, HlgA, HlgB and HlgC can form mixed pores containing all components. (Articolo in rivista)

Type
Label
  • Staphylococcus aureus bi-component g-hemolysins, HlgA, HlgB and HlgC can form mixed pores containing all components. (Articolo in rivista) (literal)
Anno
  • 2005-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1021/ci050175y (literal)
Alternative label
  • Mauro Dalla Serra;*+ Manuela Coraiola;+ Gabriella Viero;+ Massimiliano Comai;+ Cristina Potrich;+ Mercedes Ferreras;+| Lamine Baba-Moussa;?^ Didier A. Colin;? Gianfranco Menestrina;+ Sucharit Bhakdi;§ and Gilles Prevost;? (2005)
    Staphylococcus aureus bi-component g-hemolysins, HlgA, HlgB and HlgC can form mixed pores containing all components.
    in Journal of chemical information and modeling
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Mauro Dalla Serra;*+ Manuela Coraiola;+ Gabriella Viero;+ Massimiliano Comai;+ Cristina Potrich;+ Mercedes Ferreras;+| Lamine Baba-Moussa;?^ Didier A. Colin;? Gianfranco Menestrina;+ Sucharit Bhakdi;§ and Gilles Prevost;? (literal)
Pagina inizio
  • 1539 (literal)
Pagina fine
  • 1545 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 45 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • In January 2005, the title of the Journal of Chemical Information and Computer Sciences (JCICS) was revised to the Journal of Chemical Information and Modeling (JCIM) to better reflect the contents of the journal. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 6 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituto Trentino di Cultura-Consiglio Nazionale delle Ricerche (ITC-CNR) Istituto di Biofisica, Via Sommarive 18, I-38050 Povo (Trento), Italy, UPRES-EA 3432, Institut de Bacte´riologie de la Faculte´ de Me´decine, Universite´ Louis Pasteur, Rue Koeberle´ 3, F-67000 Strasbourg, France, and Institute of Medical Microbiology and Hygiene, Hochhaus am Augustusplatz, D-55101 Mainz, Germany (literal)
Titolo
  • Staphylococcus aureus bi-component g-hemolysins, HlgA, HlgB and HlgC can form mixed pores containing all components. (literal)
Abstract
  • Staphylococcal gamma-hemolysins are bicomponent toxins forming a protein family with leucocidins and alpha-toxin. Two active toxins (AB and CB) can be formed combining one of the class-S components, HlgA or HlgC, with the class-F component HlgB. These two gamma-hemolysins form pores with marked similarities to alpha-toxin in terms of conductance, nonlinearity of the current-voltage curve, and channel stability in the open state. AB and CB pores, however, are cation-selective, whereas alpha-toxin is anion-selective. gamma-Hemolysins' pores are hetero-oligomers formed by three or four copies of each component (indicated as 3A3B and 3C3B or 4A4B and 4C4B). Point mutants located on a beta-strand of the class-S component that forms part of the protomer-protomer contact region can prevent oligomer assembly. Interestingly, these mutants inhibit growth of pores formed not only by their natural components but also by nonstandard components. This lead to the hypothesis that mixed ABC pores could also be formed. By studying the conductance of pores, assembled in the presence of all three components (in different ratios), it was observed that the magnitudes expected for mixed pores were, indeed, present. We conclude that the gamma-hemolysin/leucocidin bicomponent toxin family may form a larger than expected number of active toxins by cross-combining various S and F components. (literal)
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