Nickel inhibits the slowly activating channels of radish vacuoles. (Articolo in rivista)

Type
Label
  • Nickel inhibits the slowly activating channels of radish vacuoles. (Articolo in rivista) (literal)
Anno
  • 2003-01-01T00:00:00+01:00 (literal)
Alternative label
  • Carpaneto A. (2003)
    Nickel inhibits the slowly activating channels of radish vacuoles.
    in European biophysics journal
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Carpaneto A. (literal)
Pagina inizio
  • 60 (literal)
Pagina fine
  • 66 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 32 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Titolo
  • Nickel inhibits the slowly activating channels of radish vacuoles. (literal)
Abstract
  • The mechanism of inhibition by cytoplasmic nickel of slowly activating channels in radish vacuoles was investigated using the patch-clamp technique. The decrease in the macroscopic current induced by the presence of nickel in the cytoplasmic solution can be described by a Michaelis-Menten equation with an apparent dissociation constant of 0.45+/-0.03 mM. At the single-channel level, nickel moderately decreases the single-channel conductance, since the ratio between the chord conductance in the presence and in the absence of 1 mM cytosolic nickel is 0.89+/-0.06. Experiments performed to study the interaction between calcium, an activator of the channel, and nickel strongly suggest that these two ions bind to two distinct molecular sites. A simple mathematical model predicting the experimental observations is presented. (literal)
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