Lead inhibition of NMDA channels in native and recombinant receptors. (Articolo in rivista)

Type
Label
  • Lead inhibition of NMDA channels in native and recombinant receptors. (Articolo in rivista) (literal)
Anno
  • 2001-01-01T00:00:00+01:00 (literal)
Alternative label
  • Gavazzo P. , Gazzoli A. , Mazzolini M. , Marchetti C. (2001)
    Lead inhibition of NMDA channels in native and recombinant receptors.
    in NeuroReport (Oxf.)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Gavazzo P. , Gazzoli A. , Mazzolini M. , Marchetti C. (literal)
Pagina inizio
  • 3121 (literal)
Pagina fine
  • 3125 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 12 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1: CNR (literal)
Titolo
  • Lead inhibition of NMDA channels in native and recombinant receptors. (literal)
Abstract
  • NMDA channels are key targets for lead (Pb2+) neurotoxicity and Pb2+-induced inhibition of NMDA current is age- and subunit-dependent. In rat cerebellar granule cells maintained in high KCl, glycine affinity as well as sensitivity to ifenprodil change significantly with the days in vitro, indicating a reduction of NR2B subunit expression. Pb2+ blocked NMDA current with IC50 approximately 4 microM and this effect decreased significantly during the second week in vitro. In Xenopus laevis oocytes expressing recombinant NR1-NR2A, NR1-NR2B or NR1-NR2C receptors, Pb2+ inhibited glutamate-activated currents with IC50 of 3.3, 2.5 and 4.7 microM respectively. These data indicate that Pb2+ action is dependent on subunit composition and suggest that down-regulation of the NR2B subunit is correlated to a diminished sensitivity to Pb2+ inhibition. (literal)
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