Discrepin, a novel structural class of K+ channel specific toxin, from Tityus discrepans scorpion venom. (Articolo in rivista)

Type
Label
  • Discrepin, a novel structural class of K+ channel specific toxin, from Tityus discrepans scorpion venom. (Articolo in rivista) (literal)
Anno
  • 2004-01-01T00:00:00+01:00 (literal)
Alternative label
  • D'Suze G., Batista C., Frau A., Murgia A.R., Zamudio F.Z., Sevcik C., Possani L.D. and Prestipino G. (2004)
    Discrepin, a novel structural class of K+ channel specific toxin, from Tityus discrepans scorpion venom.
    in Archives of biochemistry and biophysics (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • D'Suze G., Batista C., Frau A., Murgia A.R., Zamudio F.Z., Sevcik C., Possani L.D. and Prestipino G. (literal)
Pagina inizio
  • 256 (literal)
Pagina fine
  • 263 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 430 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Titolo
  • Discrepin, a novel structural class of K+ channel specific toxin, from Tityus discrepans scorpion venom. (literal)
Abstract
  • A new peptide was purified from the venom of the Venezuelan scorpion Tityus discrepans, by high-performance liquid chromatography and its amino acid sequence was completed by Edman degradation and mass spectrometry analysis. It contains 38 amino acid residues with a molecular weight of 4177.7 atomic mass units, tightly folded by three disulfide bridges, and has a pyroglutamic acid at the N-terminal region. This peptide, named Discrepin, was shown to block preferentially the IA currents of the voltage-dependent K+ -channel of rat cerebellum granular cells in culture. The K+ -currents are inhibited in an apparently irreversible manner, whose 50% inhibitory effect is reached with a 190 nM toxin concentration. The systematic nomenclature proposed for this toxin is alpha-KTx15.6. (literal)
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