A molecular carrier to transport and deliver cisplatin into endometrial cancer cells (Articolo in rivista)

Type
Label
  • A molecular carrier to transport and deliver cisplatin into endometrial cancer cells (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1111/j.1747-0285.2012.01337.x (literal)
Alternative label
  • Borrelli A, Schiattarella A, Musella A, Mancini R, Capasso C, De Luca V, Carginale V, Sanseverino M, Tornesello A, Gori E, Pica A, Di Santi A, Basile F, Iacobellis F, Colacurci N, Cobellis L, Mancini A. (2012)
    A molecular carrier to transport and deliver cisplatin into endometrial cancer cells
    in Chemical biology & drug design (Print); WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Borrelli A, Schiattarella A, Musella A, Mancini R, Capasso C, De Luca V, Carginale V, Sanseverino M, Tornesello A, Gori E, Pica A, Di Santi A, Basile F, Iacobellis F, Colacurci N, Cobellis L, Mancini A. (literal)
Pagina inizio
  • 9 (literal)
Pagina fine
  • 16 (literal)
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  • 80 (literal)
Rivista
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  • PubMed N. e link:doi: 10.1111/j.1747-0285.2012.01337.x. (literal)
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  • 8 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • NCI of Naples Pascale Foundation, Molecular Biology and Viral Oncogenesis, Naples, Italy 2C.N.R, Institute of Protein Biochemistry, Naples, Italy 3INBIOS srl, Naples, Italy 4Department of Statistics, University of Udine, Udine, Italy 5Department of Biological Sciences, University of Naples Federico II, Naples, Italy 6Department of Gynecology, Obstetrics and Reproduction, Second University of Naples, Naples, Italy (literal)
Titolo
  • A molecular carrier to transport and deliver cisplatin into endometrial cancer cells (literal)
Abstract
  • \"ABSTRACT: The leader peptide of a recombinant manganese superoxide dismutase (rMnSOD-Lp) acts as a molecular carrier. Clonogenic tests on normal (MRC-5) and endometrial adeno-carcinoma cells (HTB-112) were carried out in the presence of rMnSOD-Lp, cisplatin alone (CC) or cisplatin conjugated to the rMnSOD-Lp (rMnSOD-Lp-CC). The platinum delivered into the cells was measured by atomic spectrophotometric absorbance. The treatments on tumor and normal cells were finally evaluated by LM and TM microscopy. Tumor cell death in the case of 0.5 ¼M cisplatin on its own was minimal, while in the presence of 0.5 ¼M rMnSOD-Lp- CC, no tumor cells survived. Atomic absorbance analysis showed that rMnSOD-Lp-CC delivered approximately 4 times more cisplatin into HTB-112 cells than the amount delivered using cisplatin alone. By LM observation, the cells treated with rMnSOD-Lp-CC showed signs of nuclear and cytoplasmic fragmentation, i.e. apoptosis induced by the treatment. The therapeutic effect of rMnSOD-Lp-CC on endometrial cancer cells was significant, while on the normal cells it showed only a minimal toxicity. We believe that rMnSOD-Lp deserves to be considered as a molecular carrier to deliver cisplatin directly into tumor cells, thus transforming its antireplicative activity into a specific and selective antitumor agent. \" (literal)
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