An evolutionary conserved motif is responsible for Immunoglobulin heavy chain packing in the B cell membrane (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• An evolutionary conserved motif is responsible for Immunoglobulin heavy chain packing in the B cell membrane (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.ympev.2010.09.022 (literal)

Alternative label

• Varriale S.; Merlino A.; Coscia M.R.; Mazzarella L.; Oreste U. (2010)
  An evolutionary conserved motif is responsible for Immunoglobulin heavy chain packing in the B cell membrane
  in Molecular phylogenetics and evolution (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Varriale S.; Merlino A.; Coscia M.R.; Mazzarella L.; Oreste U. (literal)

Pagina inizio

• 1238 (literal)

Pagina fine

• 1244 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.ncbi.nlm.nih.gov/pubmed/20937398 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 57 (literal)

Rivista

• Molecular phylogenetics and evolution (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 3 (literal)

Note

• PubMe (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of Protein Biochemistry, CNR, via P. Castellino 111, 80131 Napoli, Italy Department of Chemistry University of Naples ''Federico II\", via Cintia, 80126 Napoli, Italy Institute of Biostructures and Bioimages, CNR, via Mezzocannone 16, 80100 Napoli, Italy (literal)

Titolo

• An evolutionary conserved motif is responsible for Immunoglobulin heavy chain packing in the B cell membrane (literal)

Abstract

• All species of vertebrates synthesize immunoglobulin molecules, which differ in an number of aspects but also share a few common features responsible for their function, such as the presence of a transmembrane domain in the membrane bound form of the immunoglobulin heavy chain (IgTMD) that ensures communication with the signal transducing Iga-Igb peptides. We have analyzed the gene sequence encoding the IgTMD of different heavy chain isotypes of very distant species, from shark to mammals. The IgTMD sequences show a high degree of sequence identity and their encoding nucleotide sequences were shown to be subject to purifying selection at most sites. We have built molecular models of seven IgTMDs from different vertebrate species and have investigated the formation of homodimer in a palmitoyl oleoyl phosphatidylcholine (POPC) lipid bilayer by Molecular Dynamics simulations. We found that the conserved FXXXFXXS/TXXXS motif, never observed to date in protein transmembrane chains, is responsible for the two heavy chains association through two pairs of Phe-Phe hydrophobic interactions and two pairs of Ser/Thr-Ser/Ser hydrogen bonds. This interaction pattern, which stabilizes the dimer conformation in the lipid bilayer, was unique, being different from any other pattern identified in transmembrane helices to date. (literal)

Prodotto di

• Institute of protein biochemistry (IBP) (Istituto)
• DR. DE BERARDINIS: SV.P03.006 (SV.P14.003.001) (Modulo)
• Institute of biostructure and bioimaging (IBB) (Istituto)

Autore CNR

• Antonello Merlino (Unità di personale esterno)
• Lelio Mazzarella (Persona)
• SONIA VARRIALE (Unità di personale esterno)
• UMBERTO ORESTE (Persona)
• MARIA ROSARIA COSCIA (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "An evolutionary conserved motif is responsible for Immunoglobulin heavy chain packing in the B cell membrane" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• UMBERTO ORESTE (Persona)
• MARIA ROSARIA COSCIA (Unità di personale interno)
• Antonello Merlino (Unità di personale esterno)
• Lelio Mazzarella (Persona)
• SONIA VARRIALE (Unità di personale esterno)

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Institute of protein biochemistry (IBP) (Istituto)
• DR. DE BERARDINIS: SV.P03.006 (SV.P14.003.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Molecular phylogenetics and evolution (Rivista)

Insieme di parole chiave di

• Parole chiave di "An evolutionary conserved motif is responsible for Immunoglobulin heavy chain packing in the B cell membrane" (Insieme di parole chiave)