Inhibition of glutamine synthetase II expression by the product of the gstl gene. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Inhibition of glutamine synthetase II expression by the product of the gstl gene. (Articolo in rivista) (literal)

Anno

• 2000-01-01T00:00:00+01:00 (literal)

Alternative label

• Spinosa M, Riccio A, Mandrich L, Manco G, Lamberti A, Iaccarino M, Merrick M, Patriarca EJ. (2000)
  Inhibition of glutamine synthetase II expression by the product of the gstl gene.
  in Molecular microbiology (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Spinosa M, Riccio A, Mandrich L, Manco G, Lamberti A, Iaccarino M, Merrick M, Patriarca EJ. (literal)

Pagina inizio

• 443 (literal)

Pagina fine

• 452 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 37 (literal)

Rivista

• Molecular microbiology (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Titolo

• Inhibition of glutamine synthetase II expression by the product of the gstl gene. (literal)

Abstract

• We report the identification of a previously unrecognized gene that is involved in the regulation of the Rhizobium leguminosarum glnII (glutamine synthetase II) gene. This gene, which is situated immediately upstream of glnII, was identified by means of a deletion/complementation analysis performed in the heterologous background of Klebsiella pneumoniae. It has been designated gstI (glutamine synthetase translational Inhibitor) because, when a complete version of gstI is present, it is possible to detect glnII-specific mRNA, but neither GSII activity nor GSII protein. The gstI gene encodes a small (63 amino acids) protein, which acts in cis or in trans with respect to glnII and is transcribed divergently with respect to glnII from a promoter that was found to be strongly repressed by the nitrogen transcriptional regulator NtrC. A mutated version of GstI lacking the last 14 amino acids completely lost its capacity to repress glnII expression. Our results indicate that gstI mediates the translation inhibition of glnII mRNA and, based on in silico analyses, a mechanism for GstI action is proposed. (literal)

Prodotto di

• Istituto di biochimica delle proteine (IBP) (Istituto)

Autore CNR

• GIUSEPPE MANCO (Unità di personale interno)
• LUIGI MANDRICH (Unità di personale esterno)

Incoming links:

Autore CNR di

• GIUSEPPE MANCO (Unità di personale interno)
• LUIGI MANDRICH (Unità di personale esterno)

Prodotto

• Istituto di biochimica delle proteine (IBP) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Molecular microbiology (Rivista)