L-Carnitine in the treatment of fatigue in adult celiac disease patients A pilot study (Articolo in rivista)

Type
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  • L-Carnitine in the treatment of fatigue in adult celiac disease patients A pilot study (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.dld.2007.06.013 (literal)
Alternative label
  • Ciacci C.; Peluso G.; Iannoni E.; Siniscalchi M.; Iovino P.; Rispo A.; Tortora R.; Bucci C.; Zingone F.; Margarucci S.; Calvani M. (2007)
    L-Carnitine in the treatment of fatigue in adult celiac disease patients A pilot study
    in Digestive and Liver Disease
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Ciacci C.; Peluso G.; Iannoni E.; Siniscalchi M.; Iovino P.; Rispo A.; Tortora R.; Bucci C.; Zingone F.; Margarucci S.; Calvani M. (literal)
Pagina inizio
  • 922 (literal)
Pagina fine
  • 928 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 39 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 10 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Gastrointestinal Unit, Department of Clinical and Experimental Medicine, University Federico II, Naples, Italy Institute of Protein Biochemistry - CNR, Naples, Italy Sigma-tau S.p.A. Pomezia (RM), Italy (literal)
Titolo
  • L-Carnitine in the treatment of fatigue in adult celiac disease patients A pilot study (literal)
Abstract
  • BACKGROUND: Fatigue is common in celiac disease. L-Carnitine blood levels are low in untreated celiac disease. L-Carnitine therapy was shown to improve muscular fatigue in several diseases. AIM: To evaluate the effect of L-carnitine treatment in fatigue in adult celiac patients. METHODS: Randomised double-blind versus placebo parallel study. Thirty celiac disease patients received 2g daily, 180 days (L-carnitine group) and 30 were assigned to the placebo group (P group). The patients underwent clinical investigation and questionnaires (Scott-Huskisson Visual Analogue Scale for Asthenia, Verbal Scale for Asthenia, Zung Depression Scale, SF-36 Health Status Survey, EuroQoL). OCTN2 levels, the specific carnitine transporter, were detected in intestinal tissue. RESULTS: Fatigue measured by Scott-Huskisson Visual Analogue Scale for Asthenia was significantly reduced in the L-carnitine group compared with the placebo group (p=0.0021). OCTN2 was decreased in celiac patients when compared to normal subjects (-134.67% in jejunum), and increased after diet in both celiac disease treatments. The other scales used did not show any significant difference between the two celiac disease treatment groups. CONCLUSION: L-Carnitine therapy is safe and effective in ameliorating fatigue in celiac disease. Since L-carnitine is involved in muscle energy production its decreased absorption due to OCTN2 reduction might explain muscular symptoms in celiac disease patients. The diet-induced OCTN2 increase, improving carnitine absorption, might explain the L-carnitine treatment efficacy. (literal)
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