Multislice multiecho T2* MRI approach for the detection of myocardial iron distribution: Validation in healthy subjects and thalassemia major patients (Contributo in atti di convegno)

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Label
  • Multislice multiecho T2* MRI approach for the detection of myocardial iron distribution: Validation in healthy subjects and thalassemia major patients (Contributo in atti di convegno) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Alternative label
  • Pepe A.; Cracolici E.; Positano V.; Pitrolo L.; Prossomariti L.; De Marchi D.; Midiri M.; Lombardi M. (2006)
    Multislice multiecho T2* MRI approach for the detection of myocardial iron distribution: Validation in healthy subjects and thalassemia major patients
    in ECR 2006, Vienna
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Pepe A.; Cracolici E.; Positano V.; Pitrolo L.; Prossomariti L.; De Marchi D.; Midiri M.; Lombardi M. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • In: ECR 2006 (Vienna, 3-7 March 2006). Proceedings, pp. B280-. (European Radiology). Springer, 2006. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • ABSTRACT: Purpose: To validate the multislice multiecho T2*MR imaging approach, for the detection of myocardial iron distribution, in healthy subjects and in thalassemia major (TM) patients. Methods and Materials: Three short axis views of the left ventricle were obtained using T2* multiecho sequences in 20 healthy subjects and in 53 TM patients. The myocardium was segmented into 12 segments. T2* value on each segment and the global T2* value were calculated. To assess the endomyocardial and epimyocardial iron distribution, each segment was divided in the inner and outer half. Results: The coefficients of variation for intra-, inter-observer and inter-study reproducibility were 3.9%, 5.5%, 4.7% respectively. In healthy subjects the percentage of deviation (%D) of the slices from the global heart T2* mean was not statistically significant. The %D of the segments from the global heart T2* mean ranged from -20 to 18. Significant differences were observed only among the segments with higher %D (5/66 cases). In TM patients, the epimyocardial iron concentration was significantly higher in the slices and in 10/12 segments. Three groups of patients were identified: 15% with homogeneous myocardial iron overload (MIO); 47% with no MIO; 38% with a heterogeneous MIO (T2* segments 20 ms and T2* segments 20 ms). Serum ferritin levels, liver iron concentrations and urinary iron excretions were significant different among groups. Conclusion: Our data did not account for rejecting certain slices or segments. Multislice multiecho T2* MR imaging approach provides a reproducible way for assessing myocardial iron distribution, which may play a role in clinical arena. (literal)
Titolo
  • Multislice multiecho T2* MRI approach for the detection of myocardial iron distribution: Validation in healthy subjects and thalassemia major patients (literal)
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