Simulating Epstein Barr Virus Infection with C-ImmSim (Articolo in rivista)

Type
Label
  • Simulating Epstein Barr Virus Infection with C-ImmSim (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1093/bioinformatics/btm044 (literal)
Alternative label
  • Castiglione F., Duca K.A., Jarrah A., Laubenbacher R., Luzuriaga K., Hochberg D. (2007)
    Simulating Epstein Barr Virus Infection with C-ImmSim
    in Bioinformatics (Oxf., Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Castiglione F., Duca K.A., Jarrah A., Laubenbacher R., Luzuriaga K., Hochberg D. (literal)
Pagina inizio
  • 1371 (literal)
Pagina fine
  • 1377 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 23 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 11 (literal)
Note
  • PubMed (literal)
  • Scopu (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1Istituto Applicazioni del Calcolo (IAC) \"M. Picone\"-CNR, Viale del Policlinico, 137, 00161 - Rome, Italy, 2Virginia Bioinformatics Institute, Washington St., MC 0477, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 and 3Department of Pathology Jaharis Building, Tufts University School of Medicine, 150 Harrison Ave., Boston, MA 02111, USA (literal)
Titolo
  • Simulating Epstein Barr Virus Infection with C-ImmSim (literal)
Abstract
  • Motivation: Epstein-Barr virus (EBV) infects greater than 90% of humans benignly for life but can be associated with tumors. It is a uniquely human pathogen that is amenable to quantitative analysis; however, there is no applicable animal model. Computer models may provide a virtual environment to perform experiments not possible in human volunteers. Results: We report the application of a relatively simple stochastic cellular automaton (C-ImmSim) to the modeling of EBV infection. Infected B-cell dynamics in the acute and chronic phases of infection correspond well to clinical data including the establishment of a long term persistent infection (up to 10 years) that is absolutely dependent on access of latently infected B cells to the peripheral pool where they are not subject to immunosurveillance. In the absence of this compartment the infection is cleared. Availability: The latest version 6 of C-ImmSim is available under the GNU General Public License and is downloadable from www.iac. cnr.it/?filippo/cimmsim.html Contact: david.thorley-lawson@tufts.edu (literal)
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