http://www.cnr.it/ontology/cnr/individuo/prodotto/ID782
Multi-nuclear MRS and F-19 MRI of F-19-labelled and B-10-enriched p-boronophenylalanine-fructose complex to optimize boron neutron capture therapy: phantom studies at high magnetic fields (Articolo in rivista)
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- Multi-nuclear MRS and F-19 MRI of F-19-labelled and B-10-enriched p-boronophenylalanine-fructose complex to optimize boron neutron capture therapy: phantom studies at high magnetic fields (Articolo in rivista) (literal)
- Anno
- 2006-01-01T00:00:00+01:00 (literal)
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Porcari, P; Capuani, S; Campanella, R; La Bella, A; Migneco, LM; Maraviglia, B (2006)
Multi-nuclear MRS and F-19 MRI of F-19-labelled and B-10-enriched p-boronophenylalanine-fructose complex to optimize boron neutron capture therapy: phantom studies at high magnetic fields
in Physics in medicine and biology (Print)
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- Porcari, P; Capuani, S; Campanella, R; La Bella, A; Migneco, LM; Maraviglia, B (literal)
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- Univ Roma La Sapienza, Dept Phys, CNR, INFM,SOFT, Rome, Italy; Enrico Fermi Ctr, Rome, Italy; Univ Perugia, Dept Phys, I-06100 Perugia, Italy; Univ Roma La Sapienza, Dept Chem, I-00185 Rome, Italy; IRCCS, Santa Lucia Fdn, Rome, Italy (literal)
- Titolo
- Multi-nuclear MRS and F-19 MRI of F-19-labelled and B-10-enriched p-boronophenylalanine-fructose complex to optimize boron neutron capture therapy: phantom studies at high magnetic fields (literal)
- Abstract
- Reaction yield optimization for the synthesis and the complexation of a boron neutron capture therapy agent F-19-labelled, B-10-enriched p-boronophenylalanine-fructose (F-19-BPA-fr) complex was obtained. H-1, F-19, C-13 and B-10 magnetic resonance spectroscopy (MRS) of the F-19-BPA-fr complex in aqueous and rat blood solution phantoms and its spatial distribution mapping using F-19 magnetic resonance imaging (MRI) results are reported. 7 T and 9.4 T magnetic fields were used to perform MRI and MRS respectively. Our in vitro results suggest that in vivo studies on F-19-BPA through F-19 NMR will be feasible. (literal)
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