Selection of escape mutants from immune recognition during HIV infection (Articolo in rivista)

Type
Label
  • Selection of escape mutants from immune recognition during HIV infection (Articolo in rivista) (literal)
Anno
  • 2002-01-01T00:00:00+01:00 (literal)
Alternative label
  • M. Bernaschi, F. Castiglione (2002)
    Selection of escape mutants from immune recognition during HIV infection
    in Immunology and cell biology (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • M. Bernaschi, F. Castiglione (literal)
Pagina inizio
  • 307 (literal)
Pagina fine
  • 313 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 80 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • The C-ImmSim model allows to track the HIV evolution in a bit string space under the selective pressure of the immune system. (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituto Applicazioni del Calcolo \"M.Picone\" CNR Viadel del Policlinico 137 00161 - Roma (literal)
Titolo
  • Selection of escape mutants from immune recognition during HIV infection (literal)
Abstract
  • We present computer simulations of the HIV infection based on a sophisticated cellular automata model of the immune response. The infection progresses following the well known three-phases dynamics observed in patients, that is, acute, silent and acquired immunodeficiency. Antigenic shift and selection of escape viral mutants with low transcription rate explain the long-term course of the asymptomatic phase, while the immunodeficiency status appears to be the consequence of a drastic reduction in T helper cell repertoire (literal)
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