http://www.cnr.it/ontology/cnr/individuo/prodotto/ID7708
Selection of escape mutants from immune recognition during HIV infection (Articolo in rivista)
- Type
- Label
- Selection of escape mutants from immune recognition during HIV infection (Articolo in rivista) (literal)
- Anno
- 2002-01-01T00:00:00+01:00 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- M. Bernaschi, F. Castiglione (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
- The C-ImmSim model allows to track the HIV evolution in a bit string space under the selective pressure of the immune system. (literal)
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Istituto Applicazioni del Calcolo \"M.Picone\"
CNR
Viadel del Policlinico 137
00161 - Roma (literal)
- Titolo
- Selection of escape mutants from immune recognition during HIV infection (literal)
- Abstract
- We present computer simulations of the HIV infection based on a
sophisticated cellular automata model of the immune response. The
infection progresses following the well known three-phases dynamics
observed in patients, that is, acute, silent and acquired
immunodeficiency. Antigenic shift and selection of escape viral
mutants with low transcription rate explain the long-term course of
the asymptomatic phase, while the immunodeficiency status appears to
be the consequence of a drastic reduction in T helper cell
repertoire (literal)
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- Autore CNR
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