Networks and circuits in cell regulation (Articolo in rivista)

Type
Label
  • Networks and circuits in cell regulation (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.bbrc.2010.05.015 (literal)
Alternative label
  • Palumbo, P.; Mavelli, G.; Farina, L.; Alberghina, L. (2010)
    Networks and circuits in cell regulation
    in Biochemical and biophysical research communications (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Palumbo, P.; Mavelli, G.; Farina, L.; Alberghina, L. (literal)
Pagina inizio
  • 881 (literal)
Pagina fine
  • 886 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.sciencedirect.com/science/article/pii/S0006291X10008934 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 396 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 6 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • L. Farina: Dipartimento di Informatica e Sistemistica ''Antonio Ruberti\", Università di Roma La Sapienza, Via Ariosto 25, 00185 Roma, Italy L. Alberghina: Dipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy (literal)
Titolo
  • Networks and circuits in cell regulation (literal)
Abstract
  • Large-scale ''omics\" data are often represented as networks of interacting components, but such representation is inherently static and, as such, cannot provide a realistic picture of the temporal dynamics of complex cellular functions. These difficulties suggest moving to a modeling strategy that explicitly takes into account both the wiring of the components and the task they perform. From an engineering perspective, this problem resembles that of ''circuit analysis\". In this paper, we focus on a limited but relevant biological circuit, the G1 to S transition in yeast cell cycle, and investigate both the network representation and the corresponding circuit described by a mathematical model, by means of a wide range of numerical simulation analysis. Reliable predictions of system-level properties are achieved and the parameters that mostly affect these properties are found out. (literal)
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