Statistical assessment of MSigDB gene sets in colon cancer (Articolo in rivista)

Type
Label
  • Statistical assessment of MSigDB gene sets in colon cancer (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Alternative label
  • A. Distaso, L. Abatangelo, R. Maglietta, T.M. Creanza, A. Piepoli, M. Carella, A. D'Addabbo, S. Mukherjee and N. Ancona (2008)
    Statistical assessment of MSigDB gene sets in colon cancer
    in Lecture notes in computer science
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • A. Distaso, L. Abatangelo, R. Maglietta, T.M. Creanza, A. Piepoli, M. Carella, A. D'Addabbo, S. Mukherjee and N. Ancona (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1. ISSIA-CNR, Via Amendola 122/D-I, 70126 Bari, Italy 2. IRCCS-Casa Sollievo della So®erenza Ospedale, San Giovanni Rotondo (FG), Italy 3. Institute for Genome Sciences & Policy, Durham, NC 27708 (literal)
Titolo
  • Statistical assessment of MSigDB gene sets in colon cancer (literal)
Abstract
  • Gene expression profiling offers a great opportunity for understanding the key role of genes in alterations which drive a normal cell to a cancer state. A deep understanding of the mechanisms of tumorigen- esis can be reached focusing on deregulation of gene sets or pathways. To this end, we measure the amount of deregulation and assess the statistical significance of predefined pathways belonging to MSigDB collection in a colon cancer data set by using two known and statistically well founded methods. Our study highlights the importance of using gene sets for understanding the main biological processes and pathways involved in colorectal cancer. Our analysis shows that many of the genes involved in these pathways, although obtained in studies on different cancer diseases, are strongly associated to colorectal tumorigenesis. (literal)
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