Sex hormone-binding globulin levels and cardiovascular risk factors in morbidly obese subjects before and after weight reduction induced by diet or malabsorptive surgery (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Sex hormone-binding globulin levels and cardiovascular risk factors in morbidly obese subjects before and after weight reduction induced by diet or malabsorptive surgery (Articolo in rivista) (literal)

Anno

• 2002-01-01T00:00:00+01:00 (literal)

Alternative label

• Mingrone, G.; Greco, A.V.; Giancaterini, A.; Scarfone, A.; Castagneto, M.; Pugeat, M. (2002)
  Sex hormone-binding globulin levels and cardiovascular risk factors in morbidly obese subjects before and after weight reduction induced by diet or malabsorptive surgery
  in Atherosclerosis (Amst.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Mingrone, G.; Greco, A.V.; Giancaterini, A.; Scarfone, A.; Castagneto, M.; Pugeat, M. (literal)

Pagina inizio

• 455 (literal)

Pagina fine

• 462 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 161 (literal)

Rivista

• Atherosclerosis (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• Number 2 (literal)

Note

• ISI Web of Science (WOS) (literal)

Titolo

• Sex hormone-binding globulin levels and cardiovascular risk factors in morbidly obese subjects before and after weight reduction induced by diet or malabsorptive surgery (literal)

Abstract

• One of the main goals of weight reduction in morbidly obese subjects is its benefit on coronary heart disease (CHD) risk. A cross-sectional study was designed to randomly assign 79 morbidly obese subjects (27 men and 52 women; age: 30-45 years) either to a diet protocol (20 kcal per kg fat- free mass (FFM); 55% carbohydrates, 30% fat, and 15% proteins) or to malabsorptive surgery (biliopancreatic diversion). Fatness parameters, measured by dual-energy X-ray absorptiometry, lipid profile, insulin, leptin, sex steroid hormones and sex hormone-binding globulin (SHBG) levels were compared at baseline and 1 year after the beginning of the study. The data showed that plasma SHBG levels, but not testosterone levels, correlated negatively to fasting insulin levels and positively to HDL-cholesterol in both men and women. Total leptin levels were significantly lower (P<0.0001) in post-BPD subjects of both sexes compared to dietary treated obese subjects. The logarithm of plasma leptin correlated significantly and positively with insulin but negatively with SHBG.A step-down regression analysis showed that FFM and SHBG, but not insulin levels, were the most powerful independent variables for predicting HDL-cholesterol levels in morbidly obese patients. The negative relationship between SHBG levels and CHD risk appears to be mediated by a concomitant variation in body fatness. Finally, in obese patients, SHBG levels seem to be an indicator of total adiposity rather than an index of an altered insulin/glucose homeostasis. (literal)

Prodotto di

• Modelli e Metodi Matematici in Fisiopatologia (ME.P06.002.001) (Modulo)
• Istituto di analisi dei sistemi ed informatica \"Antonio Ruberti\" (IASI) (Istituto)

Autore CNR

• MARCO CASTAGNETO (Persona)

Incoming links:

Prodotto

• Istituto di analisi dei sistemi ed informatica \"Antonio Ruberti\" (IASI) (Istituto)
• Modelli e Metodi Matematici in Fisiopatologia (ME.P06.002.001) (Modulo)

Autore CNR di

• MARCO CASTAGNETO (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Atherosclerosis (Rivista)