Non-coding RNAs change their expression profiles after Retinoid induced differentiation of the promyelocytic cell line NB4. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Non-coding RNAs change their expression profiles after Retinoid induced differentiation of the promyelocytic cell line NB4. (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1186/1756-500-3-24 (literal)

Alternative label

• Rossi A; D'Urso OF; Gatto G; Poltronieri P; Ferracin M; Remondelli P; Negrini M; Caporaso MG; Bonatti S; Mallardo M (2010)
  Non-coding RNAs change their expression profiles after Retinoid induced differentiation of the promyelocytic cell line NB4.
  in BMC research notes
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Rossi A; D'Urso OF; Gatto G; Poltronieri P; Ferracin M; Remondelli P; Negrini M; Caporaso MG; Bonatti S; Mallardo M (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Si tratta di una collaborazione internazionale, con analisi di espressione con DNA arrays di microRNAs eseguita negli Stati Uniti dal gruppo di Carlo Croce alla Columbus University (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 3;24 (literal)

Rivista

• BMC research notes (Rivista)

Note

• PubMe (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Università di Ferrara Università di Napoli Università del Salento (literal)

Titolo

• Non-coding RNAs change their expression profiles after Retinoid induced differentiation of the promyelocytic cell line NB4. (literal)

Abstract

• Background: The importance of non-coding RNAs (ncRNAs) as fine regulators of eukaryotic gene expression has emerged by several studies focusing on microRNAs (miRNAs). miRNAs represent a newly discovered family of non coding-RNAs. They are thought to be crucial players of human hematopoiesis and related tumorigenesis and to represent a potential tool to detect the early stages of cancer. More recently, the expression regulation of numerous long ncRNAs has been linked to cell growth, differentiation and cancer although the molecular mechanism of their function is still unknown. NB4 cells are promyelocytic cells that can be induced to differentiation upon retinoic acid (ATRA) treatment and represent a feasible model to study changes of non coding RNAs expression between cancer cells and their terminally differentiated counterpart. Findings: we screened, by microarray analysis, the expression of 243 miRNAs and 492 human genes transcribing for putative long ncRNAs different from miRNAs in NB4 cells before and after ATRA induced differentiation. Our data show that 8 miRNAs, and 58 long ncRNAs were deregulated by ATRA induced NB4 differentiation. Conclusion: our data suggest that ATRA-induced differentiation lead to deregulation of a large number of the ncRNAs that can play regulatory roles in both tumorigenesis and differentiation. (literal)

Prodotto di

• Biotecnologie per la qualità e sicurezza degli alimenti (AG.P05.007.001) (Modulo)
• Microbiologia e qualità delle produzioni alimentari (AG.P05.016.001) (Modulo)
• Istituto di scienze delle produzioni alimentari (ISPA) (Istituto)

Autore CNR

• PALMIRO POLTRONIERI (Persona)

Insieme di parole chiave

• Parole chiave di "Non-coding RNAs change their expression profiles after Retinoid induced differentiation of the promyelocytic cell line NB4." (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di scienze delle produzioni alimentari (ISPA) (Istituto)
• Microbiologia e qualità delle produzioni alimentari (AG.P05.016.001) (Modulo)
• Biotecnologie per la qualità e sicurezza degli alimenti (AG.P05.007.001) (Modulo)

Autore CNR di

• PALMIRO POLTRONIERI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• BMC research notes (Rivista)

Insieme di parole chiave di

• Parole chiave di "Non-coding RNAs change their expression profiles after Retinoid induced differentiation of the promyelocytic cell line NB4." (Insieme di parole chiave)